Ebselen | Solubility of Things

Identification

Molecular formula

C₁₃H₉NOSe

CAS number

60940-34-3

IUPAC name

2-phenyl-1,2-benzoselenazol-3-one

State

Ebselen is typically a solid at room temperature, forming a crystalline powder. It is known for its stability and low volatility.

Melting point (Celsius)

203.00

Melting point (Kelvin)

476.00

Boiling point (Celsius)

540.00

Boiling point (Kelvin)

813.00

General information

Molecular weight

274.18g/mol

Molar mass

274.1330g/mol

Density

2.0030g/cm³

Appearence

Ebselen appears as a pale yellow, crystalline powder. Under microscopic observation, the crystals have a needle-like appearance and can appear light yellow when viewed en masse.

Comment on solubility

Solubility of 2-phenyl-1,2-benzoselenazol-3-one

2-phenyl-1,2-benzoselenazol-3-one (C₁₃H₉NOSe) displays unique solubility characteristics due to its molecular structure. Understanding its solubility is essential for various applications in organic chemistry and materials science.

Key Points on Solubility:

Solvent Interaction: This compound is likely to exhibit varying solubility in organic solvents like ethanol, methanol, and dimethyl sulfoxide (DMSO) due to the polar nature of the nitrogen and oxygen atoms, which can engage in hydrogen bonding.
Insolubility in Water: Generally, compounds possessing a significant nonpolar content, such as 2-phenyl-1,2-benzoselenazol-3-one, tend to be insoluble in polar solvents such as water. The presence of a phenyl group increases hydrophobic interactions, further diminishing solubility in aqueous environments.
Temperature Dependence: The solubility can also vary with temperature; compounds may dissolve better at elevated temperatures, a factor often considered in crystallization processes.
Concentration Effects: In certain conditions, the solubility behavior can be influenced by the concentration of solutes in the solvent, leading to interesting phenomena like saturation thresholds.

As a rule of thumb, it is essential to evaluate the specific interactions that 2-phenyl-1,2-benzoselenazol-3-one can have with chosen solvents to fully understand its solubility profile. Each solvent could reveal different levels of compatibility and dissolution potential, making solubility a fascinating topic to explore further.

Interesting facts

Interesting Facts about 2-phenyl-1,2-benzoselenazol-3-one

2-phenyl-1,2-benzoselenazol-3-one is a fascinating compound in the realm of organic chemistry, notable for its unique structure and diverse applications. Here are some key points that highlight its importance:

Structure and Composition: This compound features a selenazole ring, which is an intriguing aspect since selenium is known for its ability to exhibit antioxidant properties that are distinct from sulfur.
Biological Activity: Research has shown that compounds containing selenazole scaffolds, like 2-phenyl-1,2-benzoselenazol-3-one, can exhibit antimicrobial and anticancer activities, making them potential candidates for new therapeutic agents.
Fluorescence Properties: This compound is noted for its unique fluorescence, enabling it to be used in various sensors and imaging applications in biological studies.
Synthetic Importance: The synthesis of 2-phenyl-1,2-benzoselenazol-3-one often involves strategic reactions that expand its framework, making it a valuable intermediate in the synthesis of more complex organic molecules.
Research Interest: The study of selenazole derivatives is gaining traction in medicinal chemistry. The ability of selenium-containing compounds to stabilize reactive oxygen species is a growing research focus.

Overall, 2-phenyl-1,2-benzoselenazol-3-one is more than just a compound; it embodies the intersection of chemistry and biology with promising implications in pharmaceuticals and materials science. As noted by researchers, "The future of selenazole chemistry is vibrant, and compounds like this one will lead the charge."

Synonyms

ebselen

60940-34-3

2-Phenyl-1,2-benzisoselenazol-3(2H)-one

Ebselene

Ebseleno

Ebselenum

2-phenyl-1,2-benzoselenazol-3-one

2-phenylbenzo[d][1,2]selenazol-3(2H)-one

SPI-1005

Ebselen [INN]

Ebselene [French]

Ebselenum [Latin]

Ebseleno [Spanish]

Harmokisane

C13H9NOSe

PZ 51

DR-3305

PZ51

PZ-51

DR3305

CCRIS 3714

MLS000028488

1,2-Benzisoselenazol-3(2H)-one, 2-phenyl-

2-phenyl-1,2-benzoisoselenazol-3(2H)-one

NSC 639762

DR 3305

2-Phenyl-1,2-benzisoselenazolin-3-one

SMR000058445

UNII-40X2P7DPGH

40X2P7DPGH

MFCD00210937

CHEMBL51085

NSC-639762

NSC-757883

Prestwick_1057

DTXSID7045150

CHEBI:77543

SPI1005

EBSELEN [JAN]

SPI-3005

EBSELEN [MI]

Prestwick0_000740

Prestwick1_000740

Prestwick2_000740

Prestwick3_000740

Spectrum2_001441

Spectrum3_000799

Spectrum4_000445

Spectrum5_001713

EBSELEN [MART.]

Lopac-E-3520

NSC639762

EBSELEN [WHO-DD]

Lopac0_000541

NCGC00015412-06

2-phenyl-1,2-benzoselenazol-3(2h)-one

BSPBio_000700

BSPBio_001342

BSPBio_002538

CPD000058445

KBioGR_000062

KBioGR_000830

KBioSS_000062

DivK1c_000951

SPBio_001301

SPBio_002639

CAS-60940-34-3

MLS001148646

BPBio1_000770

DTXCID5025150

BCBcMAP01_000149

HMS502P13

KBio1_000951

KBio2_000062

KBio2_002630

KBio2_005198

KBio3_000123

KBio3_000124

KBio3_001758

NINDS_000951

E 3520

Bio2_000062

Bio2_000542

HMS1361D04

HMS1570C22

HMS1791D04

HMS1989D04

HMS2052N09

Ebselenum (Latin)

AC-1124

IDI1_000951

IDI1_033812

QTL1_000035

NCGC00015412-01

NCGC00015412-02

NCGC00015412-03

NCGC00015412-13

NCGC00024072-03

NCGC00024072-04

NCGC00024072-05

NCGC00178610-01

NCGC00178610-02

NCGC00178610-03

EBSELEN (MART.)

AB00053217

EU-0100541

MLS-0003066.0001

BRD-K29359156-001-06-1

RP 60931

2-Phenyl-1,2-benzoselenazol-3-one (Ebselen)

SR-01000003081

AC1L1FDW

Ebselen?

CID3194

2-Phenyl-1,2-benzoisoselenazol-3(2H)-one; CCG-39161; Ebselen; Lopac E 3520; NSC 639762; PZ 51

SPI 1005

2-phenylbenzoisoselenazol-3(2H)-one

Ebselen (C5)

nchembio.109-comp1

LS-33527

SAM001247071

Opera_ID_1643

Ebselen, cysteine modifier

cid_3194

C042986

SCHEMBL33829

MLS001424261

MLS006010108

E3520_SIGMA

I09-1611

BDBM34233

GTPL10583

HMS2097C22

HMS2235A11

HMS3394N09

HMS3402D04

HMS3649O05

HMS3714C22

HMS3873N13

KUC112559N

Pharmakon1600-01501188

BCP17134

EX-A1447

SPI-1005;PZ-51

Tox21_110140

2-Phenyl-benzo[d]isoselenazol-3-one

CCG-39161

DAP001372

HB0270

NSC757883

s6676

AKOS015898841

CS-5534

DB12610

FE75162

LP00541

NC00431

SDCCGSBI-0050524.P004

KSC-325-014

NCGC00015412-04

NCGC00015412-05

NCGC00015412-07

NCGC00015412-08

NCGC00015412-09

NCGC00015412-10

NCGC00015412-11

NCGC00015412-12

NCGC00015412-21

phenyl-1,2-benzisoselenazol-3(2H)-one

2-phenyl-1,2-benzisoselazol-3(2H)-one

HY-13750

SY052687

SBI-0050524.P003

2-phenyl-1,2-benzisoselenazole-3(2H)-one

DB-072873

2-phenyl-1,2-benzoisoselenazole-3(2H)-one

E0946

NS00034501

2-phenyl-1,2-benzoisoselenazole-3-(2H)-one

2-Phenyl-benzo[d]isoselenazol-3-one(Ebselen)

C75847

2-phenyl-2,3-dihydro-1,2-benzoselenazol-3-one

AB00053217_25

Q5332073

SR-01000003081-2

SR-01000003081-7

SR-01000003081-8

BRD-K29359156-001-23-6

BRD-K29359156-001-30-1

SR-01000003081-10

SR-01000003081-14

612-054-8