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2-phenylindole

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Identification
Molecular formula
C14H11N
CAS number
948-65-2
IUPAC name
2-phenyl-1H-indole
State
State

At room temperature, 2-phenylindole is in a solid state.

Melting point (Celsius)
120.00
Melting point (Kelvin)
393.15
Boiling point (Celsius)
437.00
Boiling point (Kelvin)
710.15
General information
Molecular weight
219.27g/mol
Molar mass
219.2650g/mol
Density
1.1956g/cm3
Appearence

2-phenylindole typically appears as a pale yellow to beige solid. It is crystalline in nature and is often used in research and development settings, particularly in the study of indole derivatives.

Comment on solubility

Solubility of 2-phenyl-1H-indole

2-phenyl-1H-indole, with its intriguing structure, exhibits a notable solubility profile that is essential for various applications in organic chemistry and pharmaceuticals. Understanding the solubility of this compound involves multiple factors:

  • Solvent Dependence: It is primarily soluble in organic solvents such as ethanol, chloroform, and dimethyl sulfoxide (DMSO), but shows limited solubility in water. This is characteristic of many aromatic compounds, where non-polar segments dominate the interaction with polar solvents.
  • Structural Influence: The presence of both the phenyl and indole groups significantly contributes to *π-π stacking interactions*, leading to a tendency for aggregation in certain mediums, thus affecting its overall solubility.
  • Temperature Effects: Solubility can also vary with temperature; as the temperature rises, solubility typically increases, allowing for better dispersion in organic solvents.

In summary, while 2-phenyl-1H-indole is soluble in selected organic solvents, its limited polarity impacts its ability to dissolve in aqueous solutions. For practical applications, it is crucial to choose the appropriate solvent to achieve the desired solubility.

Interesting facts

Exploring 2-phenyl-1H-indole

2-phenyl-1H-indole is a fascinating compound that belongs to the class of indole derivatives, which are known for their diverse biological activities. This compound's structure features a phenyl group attached to the second position of the indole ring, giving it unique chemical properties. Here are some interesting aspects of 2-phenyl-1H-indole:

  • Biological Significance: Many indole derivatives, including 2-phenyl-1H-indole, have been studied for their potential therapeutic applications. They show promise in areas such as anti-cancer and anti-inflammatory activities.
  • Versatility: The presence of the phenyl group enhances the compound's chemical reactivity, making it suitable for various chemical transformations. This versatility is appealing in synthetic organic chemistry.
  • Research Interest: Scientists are continually exploring the pharmacological potential of indole compounds. Research has linked these compounds to effects on serotonin receptors, which play a crucial role in mood regulation.
  • Chemical Derivatives: 2-phenyl-1H-indole can act as a precursor for synthesizing more complex molecules. This property is significant for chemists looking to develop new drugs or materials.

In summary, 2-phenyl-1H-indole is not just a compound with a simple structure; it embodies a wealth of potential both in scientific research and practical applications. As chemists continue to unlock its secrets, this compound may lead to groundbreaking discoveries in medicine and materials science.

Synonyms
2-Phenylindole
2-PHENYL-1H-INDOLE
948-65-2
1H-Indole, 2-phenyl-
alpha-Phenylindole
.alpha.-Phenylindole
UNII-MQD44HV3P1
EINECS 213-436-3
MQD44HV3P1
NSC 15776
BRN 0132356
NSC-15776
DTXSID8061343
5-20-08-00232 (Beilstein Handbook Reference)
2phenylindole
alphaPhenylindole
2Phenyl1Hindole
Indole, 2phenyl
1H-Indole, 2-phenyl
DTXCID3048940
213-436-3
inchi=1/c14h11n/c1-2-6-11(7-3-1)14-10-12-8-4-5-9-13(12)15-14/h1-10,15
kllljcacirkbdt-uhfffaoysa-n
Indole, 2-phenyl-
Stabilizer I
2-PHENYL INDOLE
MFCD00005608
Phenylindole
MLS002638448
SMR000526281
phenyl-indole
2-phenylindol
TimTec1_005424
MLS000701322
CHEMBL75756
SCHEMBL341378
BDBM7391
SCHEMBL3835030
CHEBI:113541
HMS1549G12
HMS2233J19
HMS3371N07
NSC15776
BBL007843
CCG-15334
STK072610
AKOS000120325
2-Phenylindole, technical grade, 95%
CG-0506
CS-W010681
AC-23376
SY032900
DB-015965
EU-0034026
NS00019928
P0188
EN300-16558
VU0085923-2
AB00876244-08
AE-641/30188041
SR-01000393950
SR-01000393950-1
BRD-K85555482-001-01-1
BRD-K85555482-001-04-5
Q27194433
Z56174838
F0920-0084
F1918-0028
N-[2-(2,6-dicyano-4-methyl-phenyl)azo-5-(dipropylamino)phenyl]methanesulfonamide