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Iohexol

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Identification
Molecular formula
C19H26I3N3O9
CAS number
66108-95-0
IUPAC name
2-phenyl-2-[2,4,6-triiodo-3-(2-oxopyrrolidin-1-yl)phenoxy]acetic acid
State
State

At room temperature, iohexol is generally in a solid state as a crystalline powder. When dissolved in water, it forms a clear solution that is often used in medical applications such as contrast agents for imaging.

Melting point (Celsius)
174.00
Melting point (Kelvin)
447.00
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.00
General information
Molecular weight
821.13g/mol
Molar mass
821.1330g/mol
Density
2.0320g/cm3
Appearence

Iohexol appears as a white to off-white crystalline powder. It is highly soluble in water and forms a clear solution when dissolved properly.

Comment on solubility

Solubility of 2-phenyl-2-[2,4,6-triiodo-3-(2-oxopyrrolidin-1-yl)phenoxy]acetic acid

The solubility of 2-phenyl-2-[2,4,6-triiodo-3-(2-oxopyrrolidin-1-yl)phenoxy]acetic acid can be affected by several factors, including its chemical structure and polar nature. Here are some key points to consider:

  • Hydrophilicity vs. Hydrophobicity: The presence of multiple iodine atoms suggests that this compound has significant hydrophobic characteristics. However, the carboxylic acid group could impart some level of hydrophilicity.
  • Solvent Influence: Solubility is highly dependent on the solvent used. For example, compounds with both ionic and hydrophobic regions may show improved solubility in mixed solvents.
  • pH Sensitivity: The solubility of the acid form can change depending on the pH of the solution, potentially becoming more soluble in alkaline conditions due to deprotonation.
  • Temperature Effects: As with many chemical compounds, increasing temperature may enhance solubility, making it an important factor in various applications.

In summary, while the complex structure of 2-phenyl-2-[2,4,6-triiodo-3-(2-oxopyrrolidin-1-yl)phenoxy]acetic acid presents intriguing solubility challenges, understanding its behavior in different environments can provide clarity on its potential applications. The interplay of its hydrophobic and hydrophilic components suggests that solubility may be optimized under specific conditions.

Interesting facts

Interesting Facts about 2-Phenyl-2-[2,4,6-triiodo-3-(2-oxopyrrolidin-1-yl)phenoxy]acetic Acid

This fascinating compound is noteworthy for its unique structure and potential applications in medicinal chemistry. Here are some interesting points to consider:

  • Complexity of Structure: The compound features a phenyl ring attached to a triiodinated phenoxy moiety. The presence of iodine atoms significantly influences its chemical reactivity and biological activity.
  • Potential Medical Applications: The oxopyrrolidinyl group in its structure suggests antibiotic or anti-inflammatory properties, making it a subject of interest in drug development.
  • Intriguing Reactions: Due to the presence of multiple reactive sites, this compound could undergo a variety of chemical transformations. Researchers are often interested in how tweaks in its molecular structure can affect its efficacy and safety.
  • Stability Considerations: The introduction of iodine not only makes it an interesting candidate for imaging techniques in medical research, but it also raises questions around environmental stability and biocompatibility.
  • Research Potential: This compound is a prime example of how synthetic organic chemistry can lead to the discovery of novel therapeutic agents. It opens avenues for further studies on structure-activity relationships.

With ongoing research, 2-phenyl-2-[2,4,6-triiodo-3-(2-oxopyrrolidin-1-yl)phenoxy]acetic acid can potentially contribute to advancements in fields ranging from pharmaceuticals to materials science. Its unique properties make it an exciting subject for further exploration.