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Loperamide

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Identification
Molecular formula
C29H33ClN2O2
CAS number
53179-11-6
IUPAC name
2-phenyl-4-(1-piperidyl)-2-[2-(1-piperidyl)ethyl]butanamide
State
State

At room temperature, loperamide is in a solid state.

Melting point (Celsius)
209.00
Melting point (Kelvin)
482.15
Boiling point (Celsius)
553.20
Boiling point (Kelvin)
826.35
General information
Molecular weight
477.68g/mol
Molar mass
477.6830g/mol
Density
1.2260g/cm3
Appearence

Loperamide is a white to off-white crystalline powder.

Comment on solubility

Solubility of 2-phenyl-4-(1-piperidyl)-2-[2-(1-piperidyl)ethyl]butanamide

The solubility of 2-phenyl-4-(1-piperidyl)-2-[2-(1-piperidyl)ethyl]butanamide is quite intriguing. This compound, with its complex structure, exhibits varying solubility characteristics depending on the solvent used. Here are some key points to consider:

  • Polar Solvents: Generally, compounds with amide functional groups are soluble in polar solvents such as water and alcohol. Thus, 2-phenyl-4-(1-piperidyl)-2-[2-(1-piperidyl)ethyl]butanamide is expected to show good solubility in these environments due to the presence of the amide group.
  • Nonpolar Solvents: Conversely, the phenyl group and the hydrophobic nature of the piperidine moieties might limit solubility in nonpolar solvents like hexane or benzene. This duality often reflects the balance between polar and nonpolar interactions within the compound.
  • Temperature Influence: Like many organic compounds, the solubility can increase with temperature, which may enhance dissolution kinetics and solvate interactions.

In summary, the solubility of 2-phenyl-4-(1-piperidyl)-2-[2-(1-piperidyl)ethyl]butanamide varies significantly depending on the solvent environment. Understanding these aspects is critical for applying this compound effectively in various chemical and pharmaceutical contexts.

Interesting facts

Interesting Facts about 2-phenyl-4-(1-piperidyl)-2-[2-(1-piperidyl)ethyl]butanamide

2-phenyl-4-(1-piperidyl)-2-[2-(1-piperidyl)ethyl]butanamide, often referred to in scientific literature for its unique structure and potential applications, is a fascinating compound that has attracted the attention of many researchers. Below are some intriguing aspects of this compound:

  • Structural Complexity: The compound features a multi-ring system, containing both phenyl and piperidyl groups. This structural complexity allows for diverse interactions with biological targets, enhancing its significance in medicinal chemistry.

  • Potential Applications: Its structural configuration suggests potential as a pharmacological agent. Research indicates that compounds with similar structures may exhibit effects on neurotransmitters, posing potential applications in treating neurological and psychiatric disorders.

  • Synthesis Exploration: The synthesis of this compound can provide insights into advanced synthetic techniques. Developing effective pathways for creating such a molecule is essential for pharmaceutical development and can contribute to educational discussions on organic synthesis.

  • Intermolecular Interactions: The unique combination of the piperidyl moieties and the butanamide framework facilitates interesting intermolecular interactions, such as hydrogen bonding and π-π stacking, which are crucial for the compound's biological activity.

  • Research Avenues: Ongoing research is focusing on optimizing analogs of this compound to enhance efficacy and selectivity. This opens multiple pathways for investigating structure-activity relationships (SAR), an essential aspect of drug development.

This compound exemplifies how complex organic molecules can provide rich avenues for discovery and innovation in the field of chemistry, especially in medicinal applications. As we delve deeper into the characteristics and functions of such compounds, we continue to unravel their potential in enhancing human health and understanding biological mechanisms.

Synonyms
2977-24-4
BUTYRAMIDE, 2-PHENYL-4-PIPERIDINO-2-(2-PIPERIDINOETHYL)-
BRN 0310088
alpha,alpha-Bis(2-piperidinoethyl)phenylacetamide
DTXSID70183915
4-20-00-01267 (Beilstein Handbook Reference)
DTXCID10106406
2-phenyl-4-piperidin-1-yl-2-(2-piperidin-1-ylethyl)butanamide
2-phenyl-4-(1-piperidinyl)-2-[2-(1-piperidinyl)ethyl]butanamide