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2-phenylbutanamide

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Identification
Molecular formula
C10H13NO
CAS number
3969-05-9
IUPAC name
2-phenylbutanamide
State
State

At room temperature, 2-phenylbutanamide is in a solid state. This is a typical characteristic of many amides that tend to form crystalline structures due to strong hydrogen bonding in their molecular arrangement.

Melting point (Celsius)
98.00
Melting point (Kelvin)
371.15
Boiling point (Celsius)
288.00
Boiling point (Kelvin)
561.15
General information
Molecular weight
163.22g/mol
Molar mass
163.2110g/mol
Density
1.0820g/cm3
Appearence

2-Phenylbutanamide appears as a white crystalline solid. The compound has a characteristic amide odor. The crystals may vary in their size and shape but are generally well-defined and pure.

Comment on solubility

Solubility of 2-phenylbutanamide

2-phenylbutanamide, with the chemical formula C11H15NO, exhibits intriguing solubility characteristics due to its structural composition.

Here are some key points regarding its solubility:

  • Polar and Non-Polar Characteristics: The molecule contains both hydrophobic (non-polar) and hydrophilic (polar) functional groups, influencing its ability to dissolve in various solvents.
  • Solvent Interactions: Generally, 2-phenylbutanamide is more soluble in organic solvents such as ethanol, acetone, and dichloromethane than in water due to its hydrophobic phenyl group.
  • Temperature Influence: Like many amides, the solubility may increase with temperature, providing greater interactions with the solvent molecules at higher energies.
  • pH Sensitivity: The solubility might also depend on the pH of the solution, as the presence of acids or bases can affect the ionization state of the amide group.

In summary, while 2-phenylbutanamide demonstrates limited solubility in water, it finds better solubility in various organic solvents, making it a compound of interest in organic synthesis and pharmaceutical applications. Understanding its solubility profile is essential for optimizing its use in different chemical contexts.

Interesting facts

Interesting Facts About 2-Phenylbutanamide

2-Phenylbutanamide, also known by its various synonyms, is a member of the amide class of organic compounds. This intriguing compound has a variety of applications and properties that make it a point of interest for both chemists and industry professionals alike. Here are some noteworthy facts:

  • Biological Relevance: Amides like 2-phenylbutanamide often play critical roles in biological systems. This compound, in particular, has been studied for its potential pharmacological properties, including anti-inflammatory effects.
  • Synthetic Versatility: The synthesis of 2-phenylbutanamide can be achieved through various methods. One such pathway involves the reaction of 2-phenylbutanoic acid with ammonia, showcasing its synthetic accessibility for research and industrial applications.
  • Structural Characteristics: The structure of 2-phenylbutanamide can be visualized as a linear carbon chain with a phenyl group, contributing to its unique physical and chemical properties. The presence of both an aromatic ring and an amide functional group in the structure provides interesting avenues for reactivity.
  • Pharmaceutical Applications: Compounds in the amide category are often seen in drug formulations. Researchers are exploring the potential of 2-phenylbutanamide as a lead compound for new therapeutic agents.
  • Research Tools: Beyond its biological implications, 2-phenylbutanamide serves as a useful reagent in organic chemistry, particularly in studies related to amine and carboxylic acid interactions.

In summary, 2-phenylbutanamide is much more than just a simple chemical entity. With its diverse applications and the potential for future discoveries, this compound remains an intriguing subject within the realm of chemistry. As quoted by a renowned chemist, “The beauty of compounds like 2-phenylbutanamide lies not only in their structure but also in the myriad possibilities they present for innovation and research.”

Synonyms
2-Phenylbutyramide
2-Phenylbutanamide
90-26-6
Eusterol
Phenylbutyramide
FENBUTYRAMIDE
Geristerol
Hyposterol
Normosterolo
Phenetamid
Phenetamide
Redusterol
Substerina
Geriapan
Lipilisol
Nivonorm
Phenexan
Phenylethylacetamide
BUTYRAMIDE, 2-PHENYL-
.alpha.-Phenylbutyramide
TH 4128
Benzeneacetamide, .alpha.-ethyl-
NSC 1861
J95WO7W7D4
alpha-Phenyl-alpha-ethylacetamide
NSC-1861
a-Phenyl-a-ethylacetamide
(+/-)-2-Phenylbutyramide
.alpha.-Toluamide, .alpha.-ethyl-
PRIMIDONE IMPURITY C [EP IMPURITY]
.ALPHA.-ETHYL-.ALPHA.-PHENYLACETAMIDE
.ALPHA.-PHENYL-.ALPHA.-ETHYLACETAMIDE
(2RS)-2-Phenylbutanamide
alpha-Phenylbutyramide
Butyramide, alpha-phenyl-
PRIMIDONE IMPURITY C (EP IMPURITY)
alpha-Toluamide, alpha-ethyl-
Benzeneacetamide, alpha-ethyl-
Primidone Impurity C
EINECS 201-980-4
BRN 3197469
UNII-J95WO7W7D4
AI3-01390
MFCD00025511
Spectrum_001621
SpecPlus_000884
Benzeneacetamide,a-ethyl-
Spectrum2_000492
Spectrum3_000652
Spectrum4_000627
Spectrum5_001398
WLN: ZVY2&R
BSPBio_002283
KBioGR_001214
KBioSS_002101
4-09-00-01818 (Beilstein Handbook Reference)
DivK1c_006980
SCHEMBL232920
SPECTRUM1504223
SPBio_000383
CHEMBL3039472
CHEBI:93832
KBio1_001924
KBio2_002101
KBio2_004669
KBio2_007237
KBio3_001503
DTXSID60870423
NSC1861
CCG-39566
.ALPHA.-PHENYLBUTYRAMIDE [MI]
AKOS008977373
SB75764
ALPHA-ETHYL-ALPHA-PHENYLACETAMIDE
NCGC00095335-01
NCGC00095335-02
AC-11144
AS-81003
IP145636
DB-057192
NS00041223
D97844
BRD-A25537246-001-02-9
BRD-A25537246-001-03-7
Q27165566
Z68590268
201-980-4