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Tacrine Hydrochloride

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Identification
Molecular formula
C19H24ClN3O2
CAS number
1684-40-8
IUPAC name
[2-(phenylcarbamoyloxy)-3-(1-piperidyl)propyl] N-phenylcarbamate;hydrochloride
State
State

At room temperature, tacrine hydrochloride is in a solid state. It is stable under normal temperatures and pressures and is commonly used in its solid form in pharmaceutical applications.

Melting point (Celsius)
192.00
Melting point (Kelvin)
465.00
Boiling point (Celsius)
235.00
Boiling point (Kelvin)
508.00
General information
Molecular weight
348.85g/mol
Molar mass
348.8490g/mol
Density
1.3100g/cm3
Appearence

Tacrine hydrochloride appears as a white to off-white crystalline powder. It is known for being hygroscopic, meaning it may absorb moisture from the air. The compound is typically odorless.

Comment on solubility

Solubility of [2-(phenylcarbamoyloxy)-3-(1-piperidyl)propyl] N-phenylcarbamate; hydrochloride

The solubility of a compound can significantly influence its biological activity and effectiveness in various applications. In the case of [2-(phenylcarbamoyloxy)-3-(1-piperidyl)propyl] N-phenylcarbamate; hydrochloride, several considerations come into play:

  • Polar vs. Nonpolar: The presence of functional groups such as carbamate and hydrochloride suggests a degree of polarity that may enhance its solubility in polar solvents like water.
  • pH Dependence: The solubility of hydrochloride salts often increases in acidic environments due to protonation, emphasizing the importance of pH on its solubility profile.
  • Temperature Influence: Generally, an increase in temperature can enhance solubility, making it crucial to consider the thermal conditions during dissolution.
  • Interactions with Solvents: The ability of the compound to interact with solvents will also determine its solubility; hydrogen bonding and dipole-dipole interactions are key factors here.

As a case in point, it’s common for salts like hydrochlorides to be more soluble than their neutral counterparts. To sum up, understanding the solubility of [2-(phenylcarbamoyloxy)-3-(1-piperidyl)propyl] N-phenylcarbamate; hydrochloride is essential for optimizing its use in various chemical and pharmaceutical processes. As stated, “The right solvent can make all the difference.”

Interesting facts

Interesting Facts About [2-(phenylcarbamoyloxy)-3-(1-piperidyl)propyl] N-phenylcarbamate;hydrochloride

This compound is an intriguing member of the carbamate family, known for its diverse applications in both the pharmaceutical and agricultural sectors. As a hydrochloride salt, it is often studied due to its enhanced stability and solubility in aqueous solutions. Here are some interesting aspects of this compound:

  • Pharmaceutical Relevance: This compound exhibits potential as a therapeutic agent. Its structure suggests it could interact with certain biological pathways, which warrants further investigation in drug discovery processes.
  • Mechanism of Action: Carbamate derivatives are known to act as inhibitors of acetylcholinesterase. This feature could make the compound useful in treating cognitive disorders by enhancing cholinergic activity in the brain.
  • Hybrid Nature: The presence of both a piperidyl and phenyl carbamate moiety in its structure reflects its hybrid nature, combining properties of nitrogen-containing heterocycles with carbamate functionalities. This unique arrangement may contribute to complex pharmacological profiles.
  • Potential in Research: The compound could serve as a valuable research tool in neuropharmacology, allowing scientists to explore the effects of carbamates on neurological functions.
  • Synergistic Effects: Studies may reveal that combining this compound with other therapeutic agents could yield synergistic effects, enhancing therapeutic outcomes and minimizing side effects.

In summary, [2-(phenylcarbamoyloxy)-3-(1-piperidyl)propyl] N-phenylcarbamate;hydrochloride represents a compelling area of study, bridging the fields of medicinal chemistry and pharmacology. Its unique structure and potential applications in health sciences make it a promising candidate for future investigations.

Synonyms
DIPERODON HYDROCHLORIDE
537-12-2
Proctodon
Diperocaine
Diperodon HCl
Diothane hydrochloride
Diperdon hydrochloride
EINECS 208-659-8
NSC 76069
5YZ5R8I73Y
DTXSID1045324
NSC-76069
3-Piperidino-1,2-propanediol dicarbanilate hydrochloride
3-(1-Piperidyl)-1,2-propanediol dicarbanilate hydrochloride
DTXCID9025324
DIPERODON HYDROCHLORIDE [MI]
DIPERODON HYDROCHLORIDE [VANDF]
DIPERODON HYDROCHLORIDE [MART.]
DIPERODON HYDROCHLORIDE [WHO-DD]
1,2-Propanediol, 3-piperidino-, dicarbanilate, hydrochloride
DIPERODON HYDROCHLORIDE [GREEN BOOK]
1,2-Propanediol, 3-piperidino-, dicarbanilate (ester), monohydrochloride
1,2-Propanediol, 3-(1-piperidinyl)-, bis(phenylcarbamate) (ester), monohydrochloride
1,2-Propanediol, 3-(1-piperidinyl)-, bis(phenylcarbamato) (ester), monohydrochloride
DIPERODON HYDROCHLORIDE (MART.)
1,2-PROPANEDIOL, 3-(1-PIPERIDINYL)-, 1,2-BIS(N-PHENYLCARBAMATE), HYDROCHLORIDE (1:1)
1,2-Propanediol, 3-(1-piperidinyl)-, bis(phenylcarbamate) (ester), monohydrochloride (9CI)
1,2-Propanediol, 3-(1-piperidinyl)-, bis(phenylcarbamato) (ester), monohydrochloride (9CI)
1,2-Propanediol, 3-piperidino-, dicarbanilate (ester), monohydrochloride (8CI)
208-659-8
Diperodon (hydrochloride)
[2-(phenylcarbamoyloxy)-3-piperidin-1-ylpropyl] N-phenylcarbamate;hydrochloride
UNII-5YZ5R8I73Y
MDL 28574; 6-Butyryl castanospermine; Castanospermine 6-butyrate
Prestwick_673
d-Diothane hydrochloride
l-Diothane hydrochloride
dl-Diothane hydrochloride
NCGC00016500-01
CAS-537-12-2
MLS002154257
SCHEMBL1169004
CHEMBL1456312
NIOSH/TZ1103000
NIOSH/TZ1103100
NIOSH/TZ1103200
OWULVAZDMWJBLB-UHFFFAOYSA-N
HMS1568L22
Pharmakon1600-01505780
HY-B1226
NSC76069
Tox21_110460
NSC759247
s4397
AKOS024374933
Tox21_110460_1
CCG-213549
CS-4874
NSC-759247
NCGC00166142-04
DA-62908
SMR001233518
TS-07639
Diperodon hydrochloride, analytical standard
NS00079941
SW196828-3
TZ11030000
TZ11031000
TZ11032000
H38634
SR-01000841186
SR-01000841186-2
Q27263073
dl-Piperidinopropane-2,3-diol dicarbanilate hydrochloride
1, 3-piperidino-, dicarbanilate (ester), monohydrochloride
d-1-Piperidinopropane-2,3-diol dicarbanilate hydrochloride
l-1-Piperidinopropane-2,3-diol dicarbanilate hydrochloride
1, 3-(1-piperidinyl)-, bis(phenylcarbamate) (ester), monohydrochloride
3-(piperidin-1-yl)propane-1,2-diyl bis(phenylcarbamate) hydrochloride
(+)-3-(1-Piperidinyl)-1,2-propanediol bis(phenylcarbamate) (ester) monohydrochloride
(+-)-3-(1-Piperidinyl)-1,2-propanediol bis(phenylcarbamate) (ester) monohydrochloride
(-)-3-(1-Piperidinyl)-1,2-propanediol bis(phenylcarbamate) (ester) monohydrochloride
1,2-Propanediol, 3-piperidino-, dicarbanilate (ester), monohydrochloride, (+)-
1,2-Propanediol, 3-piperidino-, dicarbanilate (ester), monohydrochloride, (+-)-
1,2-Propanediol, 3-piperidino-, dicarbanilate (ester), monohydrochloride, (-)-
1,2-Propanediol, 3-(1-piperidinyl)-, bis(phenylcarbamate) (ester), monohydrochloride, (+)-
1,2-Propanediol, 3-(1-piperidinyl)-, bis(phenylcarbamate) (ester), monohydrochloride, (+-)-
1,2-Propanediol, 3-(1-piperidinyl)-, bis(phenylcarbamate) (ester), monohydrochloride, (-)-