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2-phenylguanidine

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Identification
Molecular formula
C7H9N3
CAS number
2002-16-6
IUPAC name
2-phenylguanidine
State
State

At room temperature, 2-phenylguanidine is a solid and generally exists in powdered form. It is stable under normal conditions and can be handled easily in a laboratory environment without special requirements.

Melting point (Celsius)
143.00
Melting point (Kelvin)
416.15
Boiling point (Celsius)
290.00
Boiling point (Kelvin)
563.15
General information
Molecular weight
149.19g/mol
Molar mass
149.1920g/mol
Density
1.1668g/cm3
Appearence

2-phenylguanidine typically appears as a white to faintly colored crystalline powder. It is known for its solid structure and is usually available in powdered form, which may clump or form lumps due to its crystalline nature.

Comment on solubility

Solubility of 2-phenylguanidine

2-phenylguanidine, also known by its systematic name as 1-phenylbiguanide, showcases fascinating solubility behavior that can be influenced by several factors. Here are some key points to consider:

  • Solvent Dependence: The solubility of 2-phenylguanidine in water is limited due to its relatively nonpolar phenyl group, which hinders favorable interactions with polar water molecules.
  • Aqueous Solubility: It has been observed that 2-phenylguanidine exhibits low solubility in water, generally around 0.05 g per 100 mL, indicating that it can be classified as poorly soluble.
  • Influence of pH: The solubility may also be affected by the pH of the solution, as guanidine derivatives can exist in protonated or deprotonated forms, which can enhance solubility under certain conditions.
  • Effect of Temperature: An increase in temperature can also improve the solubility of 2-phenylguanidine, as is common with many solid compounds.

This combination of factors renders C7H10N4 somewhat challenging to work with in aqueous environments, which is vital to consider in applications and synthesis pathways. Overall, while 2-phenylguanidine is not highly soluble in water, it may find better solubility in organic solvents, allowing for its use in a variety of chemical processes.

Interesting facts

Interesting Facts about 2-Phenylguanidine

2-Phenylguanidine, an organic compound known for its unique structure and applications, is a fascinating subject for both chemists and students. This compound features a phenyl group attached to a guanidine moiety, giving it interesting chemical properties and potential uses.

Key Properties and Uses:

  • Pharmaceutical Applications: 2-Phenylguanidine is recognized for its role in medicinal chemistry, particularly in the development of agmatine-based therapeutics, which show promise in neurological disorders.
  • Catalysis: The compound serves as a catalyst in various chemical reactions, including those involved in the synthesis of more complex organic molecules.
  • Research Interest: Scientists study 2-phenylguanidine to explore its interactions with biological systems and its effects on different biochemical pathways.

Interesting Features:

  • Dual Functionality: Its structure allows it to engage in both hydrogen bonding and coordination with metal ions, broadening its utility in coordination chemistry.
  • Reactive Intermediate: 2-Phenylguanidine can act as a reactive intermediate in organic synthesis, making it a valuable compound for researchers aiming to create new materials.
  • Environmental Impact: With increasing interest in sustainable chemistry, compounds like 2-phenylguanidine are evaluated for their minimal ecological footprint in various applications.

As a noteworthy compound, 2-phenylguanidine exemplifies the intersection of organic chemistry and pharmaceutical science. It continues to inspire research and innovation within the scientific community. Whether in the laboratory or in theoretical studies, its diverse applications make it a topic worth exploring further!

Synonyms
1-Phenylguanidine
Phenylguanidine
N-Phenylguanidine
GUANIDINE, PHENYL-
N-Phenyl-guanidine
EINECS 217-898-7
1N-amino(immino)methylaniline
DTXSID70173836
phenylguanidinium
phenylguanidinium ion
phenylguanidinium chloride
DTXCID3096327
217-898-7
qrjzgvvkgfigli-uhfffaoysa-n
2002-16-6
2-phenylguanidine
Guanidine, N-phenyl-
alpha-Phenylguanidine
CHEMBL14047
phenyl guanidine
Monophenylguanidin
N-phenyl guanidine
PL0
benzene, guanidino-
MFCD00092876
N-Phenylguanidine #
Phenylguanidine mononitrate
SCHEMBL256023
BDBM93095
ALBB-019781
BDBM50053620
AKOS000266439
guanidine, N-phenyl-, carbonate(1:1)
AS-39432
NS00026499
Q27464460
F2158-0402
Phenylguanidine; Guanidine, N-phenyl- (ACI); Guanidine, phenyl- (6CI, 7CI, 8CI, 9CI); N-Phenylguanidine (ACI); 1-Phenylguanidine; Phenylguanidine