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Amphetamine

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Identification
Molecular formula
C9H13N
CAS number
300-62-9
IUPAC name
2-phenylpropan-1-amine
State
State

At room temperature, amphetamine is in a liquid state if it’s in its free base form. However, as a salt (e.g., amphetamine sulfate), it is a solid and typically appears as a powder.

Melting point (Celsius)
11.30
Melting point (Kelvin)
284.45
Boiling point (Celsius)
203.00
Boiling point (Kelvin)
476.15
General information
Molecular weight
135.21g/mol
Molar mass
135.2060g/mol
Density
0.9400g/cm3
Appearence

Amphetamine is typically encountered as a white, crystalline powder, though it may appear as a colorless liquid in its free base form. It is also found in tablet or capsule form when used medically.

Comment on solubility

Solubility of 2-phenylpropan-1-amine

2-phenylpropan-1-amine, also known as alpha-phenylisopropylamine, exhibits specific solubility characteristics that are important in both organic chemistry and applications. Its solubility can be influenced by several factors, including:

  • Solvent Type: 2-phenylpropan-1-amine is generally soluble in non-polar and slightly polar organic solvents such as ethanol and chloroform, but has limited solubility in water due to its hydrophobic aromatic ring.
  • Temperature: Increased temperatures typically enhance solubility for many organic compounds, including amines like 2-phenylpropan-1-amine.
  • pH Level: The solubility can also be affected by the pH of the solution. In acidic conditions, it may form a positively charged ammonium ion, making it more soluble in water.

As a general observation, amines tend to have varying degrees of solubility based on their structural attributes. 2-phenylpropan-1-amine falls into a category where:

  • It shows significant solubility in organic solvents.
  • Its solubility in water may be compromised due to the bulky phenyl group.

So, when considering the practical applications or synthesis involving 2-phenylpropan-1-amine, it’s essential to account for these solubility factors to optimize reactions and formulations. Remember, “solubility is key to reactivity!

Interesting facts

Interesting Facts About 2-Phenylpropan-1-amine

2-Phenylpropan-1-amine, also known as alpha-methylphenethylamine, is a fascinating compound that falls within the family of amines, which are known for their diverse applications in the field of chemistry and pharmaceuticals. Here are some intriguing facts about this compound:

  • Reaction Characteristics: This compound is notable for its ability to engage in various organic reactions, such as reductive amination and Mannich reactions, making it a valuable intermediate in the synthesis of more complex chemical entities.
  • Biological Significance: 2-Phenylpropan-1-amine has been studied for its potential psychoactive properties. Some related compounds have been associated with stimulating effects, which have piqued the interest of researchers in neuroscience and pharmacology.
  • Synthetic Pathways: The synthesis of 2-phenylpropan-1-amine can be achieved through several methods, including the condensation of phenylacetone with ammonia, showcasing the creativity often required in synthetic chemistry.
  • Chirality: It contains a chiral center, which means it can exist as two enantiomers. This chirality can have significant implications in its biological activity and effectiveness, an aspect that is particularly important in drug design.
  • Applications: Beyond its potential pharmaceutical roles, it also serves as a precursor for various chemical syntheses, contributing to the development of dyes, agricultural chemicals, and other important compounds.

As you can see, 2-phenylpropan-1-amine is not just another simple amine; it embodies the complexity and versatility inherent in organic chemistry. Continuing to explore its properties opens new doors to understanding both its fundamental chemistry and its practical applications in various industries.

Synonyms
2-Phenylpropylamine
582-22-9
beta-Methylphenethylamine
2-phenyl-1-propanamine
2-phenyl-1-propylamine
Benzeneethanamine, .beta.-methyl-
.beta.-Methylphenethylamine
6XL7O3V13L
Benzeneethanamine, beta-methyl-
2-PHENYLPROPANAMINE
NSC-272273
DTXSID10870630
DTXCID50818334
209-479-2
(+-)-.beta.-methylphenethylamine
(+-)-2-phenylpropylamine
(+-)-beta-methylphenethylamine
2-phenylpropan-1-amine
1-Amino-2-phenylpropane
BMPEA
beta-Methylphenylethylamine
1-Propanamine, 2-phenyl-
4-Methylphenylethylamine
Propylamine, 2-phenyl-
beta-Me-PEA
b-methylphenethylamine
beta-Methylbenzeneethanamine
beta-Phenylpropylamine
1-Phenyl-1-methyl-2-aminoethane
2-Phenyl-propylamine
(2-phenylpropyl)amine
.beta.-Phenylpropylamine
1-Phenyl-1-methyl-2-amino-aethan
.beta.-Methylphenylethylamine
.beta.-Methylbenzeneethanamine
NSC 272273
Phenethylamine, .beta.-methyl-
(+/-)-.BETA.-METHYLPHENETHYLAMINE
alpha-Benzylethylamine
B-methyl phenethylamine
beta-methyl-phenethylamine
EINECS 209-479-2
(2S)-2-phenyl-1-propanamine
UNII-6XL7O3V13L
1-Phenyl-1-methyl-2-amino-aethan [German]
MFCD00216740
MFCD00216741
PHENETHYLAMINE, beta-METHYL-
(S)-(-)-B-METHYLPHENETHYLAMINE
NSC272273
2-methylphenylethylamine
beta-methylphenethyl-amine
SCHEMBL2107
2-methyl-2-phenyl-ethylamine
WLN: Z1Y1&R
benzene, (2-amino)isopropyl-
s(-)-beta-methylphenethylamine
CHEMBL158578
GTPL5510
beta-Methylphenethylamine, 99%
(+/-)-beta-methylphenethylamine
AXORVIZLPOGIRG-UHFFFAOYSA-
(RS)-2-PHENYLPROPYLAMINE
CHEBI:229522
HMS1748H06
(+/-)-2-PHENYLPROPYLAMINE
STK661607
AKOS000268967
AKOS016040167
AKOS040764367
AB04898
AB04902
PS-5808
(R)-(+)-B-METHYLPHENETHYLAMINE
PD046620
SY022702
SY030426
DB-018084
DB-053170
NS00017997
EN300-11199
F13480
Q8083976
F0001-1519
InChI=1/C9H13N/c1-8(7-10)9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3