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N-(2-Aminoethyl)piperazine

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Identification
Molecular formula
C6H15N3
CAS number
140-31-8
IUPAC name
2-piperazin-1-ylethanamine
State
State

At room temperature, N-(2-Aminoethyl)piperazine is in a liquid state. It is hygroscopic and can absorb moisture from the air.

Melting point (Celsius)
-60.50
Melting point (Kelvin)
212.65
Boiling point (Celsius)
218.00
Boiling point (Kelvin)
491.15
General information
Molecular weight
129.21g/mol
Molar mass
129.2110g/mol
Density
0.9750g/cm3
Appearence

N-(2-Aminoethyl)piperazine is a clear, colorless liquid with a slightly ammoniacal odor. The compound is generally used in the preparation of pharmaceuticals and as a curing agent for epoxy resins.

Comment on solubility

Solubility of 2-piperazin-1-ylethanamine

2-piperazin-1-ylethanamine, known for its unique chemical structure, demonstrates interesting solubility characteristics that are important in various applications. Its solubility can be influenced by several factors:

  • Polarity: The presence of amino groups in the compound generally increases its polarity, promoting solubility in polar solvents.
  • Hydrogen Bonding: 2-piperazin-1-ylethanamine is capable of forming hydrogen bonds, which enhances its interaction with water molecules, leading to increased solubility in aqueous solutions.
  • Temperature: As with many organic compounds, solubility may increase with temperature, allowing for greater dissolution in solvents.
  • pH Levels: The solubility of this amine compound may also vary with pH, as it can exist in both protonated and deprotonated forms, impacting its overall solubility in different environments.

In summary, the solubility of 2-piperazin-1-ylethanamine is largely enhanced by its polar nature and ability to engage in hydrogen bonding, making it soluble in water and other polar solvents. However, future research may reveal more specific solubility limits and implications for its use in pharmaceuticals and other chemical applications.

Interesting facts

Interesting Facts about 2-Piperazin-1-ylethanamine

2-Piperazin-1-ylethanamine, often referred to in the scientific community for its intriguing structure and pharmacological importance, is an organic compound belonging to the class of piperazine derivatives. Here are some fascinating insights about this compound:

  • Structural Significance: The presence of the piperazine ring, which consists of two nitrogen atoms in a six-membered ring, grants this compound unique properties that influence its biological activity.
  • Pharmacological Applications: 2-Piperazin-1-ylethanamine is studied for its potential uses in pharmaceutical research, particularly as a building block for various drug molecules. Its ability to interact with biological targets makes it a key player in medicinal chemistry.
  • Neurotransmitter Interaction: Compounds of this type are believed to modulate the activity of neurotransmitters, potentially leading to applications in treating conditions like anxiety and depression.
  • Synthetic Versatility: The synthesis of 2-piperazin-1-ylethanamine can be achieved through various methods, allowing chemists flexibility in developing complex molecular structures.
  • Research Interest: Ongoing studies focus on its role in enhancing the efficacy of drug delivery systems, showcasing the compound's relevance in contemporary scientific research.

In conclusion, the exploration of 2-piperazin-1-ylethanamine not only broadens our understanding of piperazine derivatives but also exemplifies the intricate relationship between chemical structure and biological function. As famous chemist Linus Pauling once said, "The best way to understand a compound is to study its interactions and applications." This compound serves as a prime example of how even small changes in molecular structure can lead to significant advancements in science and medicine.

Synonyms
140-31-8
N-(2-Aminoethyl)piperazine
N-Aminoethylpiperazine
1-(2-Aminoethyl)piperazine
1-Piperazineethanamine
2-(piperazin-1-yl)ethanamine
Aminoethylpiperazine
2-piperazin-1-ylethanamine
1-Piperazineethylamine
Piperazineethanamine
1-AMINOETHYLPIPERAZINE
2-Piperazinylethylamine
Piperazine, 1-(2-aminoethyl)-
USAF DO-46
2-Piperazin-1-ylethylamine
2-(1-Piperazinyl)ethylamine
N-(beta-Aminoethyl)piperazine
NSC 38968
CCRIS 6678
N-(Aminoethyl)piperazine
HSDB 5630
4-(2-aminoethyl)piperazine
EINECS 205-411-0
UN2815
BRN 0104363
DTXSID2021997
AI3-52274
n-aminoethyl piperazine
2-(piperazin-1-yl)ethan-1-amine
NSC-38968
I86052F9F6
n-(2-aminoethyl) piperazine
MLS000736991
DTXCID401997
PIPERAZINEETHANAMINE, 1-
N-(.beta.-Aminoethyl)piperazine
EC 205-411-0
N-(2-AMINOETHYL)PYPERAZINE
5-23-01-00257 (Beilstein Handbook Reference)
N-(2-AMINOETHYL)PIPERAZINE [HSDB]
1-[2-Aminoethyl]piperazine
28631-79-0
Ancamine AEP
CAS-140-31-8
1-Piperazine ethanamine
1-(beta-Aminoethyl)piperazine
UNII-I86052F9F6
1Piperazineethanamine
1Piperazineethylamine
MFCD00005971
2-aminoethylpiperazine
monoaminoethylpiperazine
N-2-aminoethylpiperazine
N(2Aminoethyl)piperazine
1(2Aminoethyl)piperazine
1-MAEP
N(betaAminoethyl)piperazine
Piperazine, 1(2aminoethyl)
2-piperazin-1-yl-ethylamine
SCHEMBL17210
N-(2-amino ethyl)piperazine
N-(2-aminoethyl)-piperazine
piperazine, N-2-aminoethyl-
WLN: T6M DNTJ D2Z
1-(2-aminoethyl) piperazine
1-(2-aminoethyl)-piperazine
N-(beta-aminoethyl)-piperazine
1-(2-aminoethyl)- piperazine
CHEMBL209790
D.E.H. 39 (Salt/Mix)
2-(1-Piperazinyl)ethanamine #
1-(2-Aminoethyl)piperazine, 99%
ALBB-021351
NSC38968
Tox21_202230
Tox21_302922
BBL011596
STL163329
AKOS000118842
FA75429
LF-0556
UN 2815
NCGC00249192-01
NCGC00256327-01
NCGC00259779-01
SMR000393948
DB-016170
A0304
NS00004675
EN300-17952
N-Aminoethylpiperazine [UN2815] [Corrosive]
Q3887815
Z57127897
F2191-0297
205-411-0