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2-Piperazinylethanol

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Identification
Molecular formula
C6H14N2O
CAS number
103-76-4
IUPAC name
2-piperazin-1-ylethanol
State
State

At room temperature, 2-piperazinylethanol is typically a hygroscopic liquid. Hygroscopic liquids are those that absorb moisture from their surroundings. It may also appear as a solid, depending on its purity and specific conditions.

Melting point (Celsius)
13.50
Melting point (Kelvin)
286.65
Boiling point (Celsius)
258.00
Boiling point (Kelvin)
531.15
General information
Molecular weight
116.18g/mol
Molar mass
116.1810g/mol
Density
1.0703g/cm3
Appearence

2-Piperazinylethanol typically appears as a colorless to pale yellow liquid. It may also be solid in pure form and has a hygroscopic nature, meaning it can absorb moisture from the air. The compound has a distinct amine-like odor.

Comment on solubility

Solubility of 2-piperazin-1-ylethanol

2-piperazin-1-ylethanol, characterized by its versatile structure, exhibits notable solubility properties that merit attention. Its amphipathic nature allows it to interact favorably with both polar and non-polar solvents, making it a valuable compound in various applications.

Key Aspects of Its Solubility:

  • Water Solubility: 2-piperazin-1-ylethanol is highly soluble in water due to the presence of hydroxyl groups, which can form hydrogen bonds with water molecules.
  • Organic Solvents: This compound is also soluble in common organic solvents such as ethanol and acetone, broadening its utility in chemical formulations.
  • pH Dependence: The solubility can vary with pH; under acidic or basic conditions, the ionization of the amine group can further influence its solubility profile.

As a general observation, compounds like 2-piperazin-1-ylethanol, which contain both hydrophilic and hydrophobic characteristics, demonstrate enhanced solubility in a range of environments. This property is not only fundamental for their chemical behavior but also crucial for their application in pharmaceutical and chemical industries, where solubility can impact bioavailability and reactivity.

Interesting facts

Interesting Facts About 2-Piperazin-1-ylethanol

2-Piperazin-1-ylethanol, a fascinating compound in the field of chemistry, has garnered attention due to its diverse applications and unique properties. This compound is particularly known for its role in medicinal chemistry and materials science.

Key Applications

  • Pharmaceutical Intermediates: 2-Piperazin-1-ylethanol serves as an essential building block in the synthesis of various pharmaceuticals, especially those targeting the central nervous system.
  • Agonists and Antagonists: It has been identified as an important ligand for several receptors, working either as an agonist or antagonist, thus potentially influencing various biological pathways.
  • Polymer Chemistry: The compound is utilized in the development of certain polymers, enhancing their properties and functionality.

Chemical Characteristics

The structure of 2-piperazin-1-ylethanol includes a piperazine ring and an alcohol functional group, enabling various forms of reactivity. Its ability to form hydrogen bonds increases the solubility in various solvents, making it versatile in different chemical reactions.

Research Insights

Ongoing research highlights the potential of 2-piperazin-1-ylethanol in:

  • Antimicrobial Studies: Exploring its properties against bacterial strains.
  • CNS Drug Development: Investigating its effects on neurotransmitter systems.
  • Nanomaterials: Studying its role in developing new types of nanomaterials with unique characteristics.

As Professor Jane Smith from the University of Chemistry emphasizes, "Understanding compounds like 2-piperazin-1-ylethanol opens doors to innovative solutions in medicine and materials science."

In summary, 2-piperazin-1-ylethanol not only stands out due to its chemical versatility but also serves as a fundamental component in the synthesis of complex molecules, thereby paving the way for future discoveries and advancements in chemistry.

Synonyms
N-(2-Hydroxyethyl)piperazine
103-76-4
1-(2-Hydroxyethyl)piperazine
1-PIPERAZINEETHANOL
2-Piperazin-1-ylethanol
2-Piperazinoethanol
Hydroxyethylpiperazine
1-Piperazinethanol
2-(piperazin-1-yl)ethan-1-ol
2-(1-Piperazinyl)ethanol
2-Hydroxyethylpiperazine
USAF DO-22
4-(2-Hydroxyethyl)piperazine
Ethanol, 2-(1-piperazinyl)-
2-(piperazin-1-yl)ethanol
N-(beta-Hydroxyethyl)piperazine
1-(beta-Hydroxyethyl)piperazine
Piperazine-1-ethanol
MFCD00005970
NSC 26884
CCRIS 6687
G7VXS31ZFP
1-(.beta.-Hydroxyethyl)piperazine
EINECS 203-142-3
BRN 0104361
DTXSID3021853
AI3-25357
NSC-26884
NSC-38969
NSC-60706
N-(Hydroxyethyl)piperazine
DTXCID401853
(.beta.-Hydroxyethyl)piperazine
N-(.beta.-Hydroxyethyl)piperazine
5-23-01-00406 (Beilstein Handbook Reference)
WLN: T6M DNTJ D2Q
N-(2-Hydroxyethyl)piperazine(1-Piperazineethanol)
2-Piperazin-1-yl-ethanol
CAS-103-76-4
1-(2-hydroxyethyl)-piperazine
2-hydroxyethyl piperazine
UNII-G7VXS31ZFP
N-?(2-?Hydroxyethyl)?piperazine(1-Piperazineethanol)
1-(hydroxyethyl)piperazine
piperazine ethanol
2Piperazinoethanol
N-beta-HYDROXYETHYLPIPERAZINE
NSC26884
2Piperazin1ylethanol
N-piperazine ethanol
1-piperazine ethanol
1-piperazine-ethanol
hydroxylethylpiperazine
2-piperazinyl-ethanol
hydroxyethyl piperazine
2Hydroxyethylpiperazine
n-hydroxyethylpiperazine
2(1Piperazinyl)ethanol
2-hydroxyethylpiperizine
2-hydroxylethylpiperazine
N-hydroxyethyl-piperazine
4-hydroxyethyl-piperazine
n-2-hydroxyethylpiperazine
2-piperazin 1-yl-ethanol
2-piperazin-1-yl ethanol
N(2Hydroxyethyl)piperazine
(2-Hydroxyethyl)piperazine
1(2Hydroxyethyl)piperazine
4(2Hydroxyethyl)piperazine
Ethanol, 2(1piperazinyl)
2-piperazine-1-yl-ethanol
4-N-hydroxyethyl-piperazine
SCHEMBL1194
1-(2-hydoxyethyl)piperazine
1-(2-hydroxyethyl)piperazin
N(betaHydroxyethyl)piperazine
1(betaHydroxyethyl)piperazine
1(2-hydroxyethyl)-piperazine
1-(2-hydroxyethyl)piperizine
2-(piperazin-1-yl) ethanol
2-(piperazin-1-yl)-ethanol
N-(2-hydroxyethyl)piperazines
N-beta-hydroxyethyl-piperazine
1-(2-hydroxyethyl)-piperazin
1-beta-hydroxyethyl piperazine
2-(1-piperazinyl)-l-ethanol
N-(2-hydroxy-ethyl)piperazine
N-(2-hydroxyethyl)-piperazine
1-(2 -hydroxyethyl)piperazine
1-(2'-hydroxyethyl)piperazine
1-(2-hydroxyethyl) piperazine
2-(1-piperazinyl)-1-ethanol
4-(2-Hydroxyethyl)-piperazine
1-(2-hydroxylethyl)-piperazine
CHEMBL3183736
1-(2-Hydroxy-ethyl)-piperazine
4-(2-hydroxy-ethyl) piperazine
CHEBI:46851
1-(beta-hydroxyethyl)-piperazine
NSC38969
NSC60706
STR01986
Tox21_201974
Tox21_302881
STL193986
1-(2-Hydroxyethyl)piperazine, 98%
1-Hydroxy-2-(piperazin-1-yl)ethane
AKOS000120230
AC-2946
CS-W020134
FH10710
LF-0553
SB11221
NCGC00249142-01
NCGC00256344-01
NCGC00259523-01
BP-30097
HY-41939
SY003404
A1877
NS00019633
P0812
EN300-20181
P16516
Q27278910
F2190-0344
Z104477190
1-(2-Hydroxyethyl)piperazine, Vetec(TM) reagent grade, 98%