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Benztropine mesylate (as chloride)

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Identification
Molecular formula
C21H26ClN1O3
CAS number
132-17-2
IUPAC name
2-piperidin-1-ium-1-ylethyl N-(2-benzyloxyphenyl)carbamate;chloride
State
State

At room temperature, benzotrapine mesylate chloride stays in a solid state as a crystalline powder.

Melting point (Celsius)
113.00
Melting point (Kelvin)
386.15
Boiling point (Celsius)
235.00
Boiling point (Kelvin)
508.15
General information
Molecular weight
405.95g/mol
Molar mass
405.9500g/mol
Density
1.1000g/cm3
Appearence

The compound generally appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 2-Piperidin-1-ium-1-ylethyl N-(2-benzyloxyphenyl)carbamate; chloride

The solubility of 2-piperidin-1-ium-1-ylethyl N-(2-benzyloxyphenyl)carbamate; chloride is an intriguing aspect of its chemical behavior. This compound is a quaternary ammonium salt, which often influences its solubility in various solvents. Here are some key points to consider:

  • Solvent Polarity: The solubility can vary significantly depending on the polarity of the solvent used. Typically, such compounds solubilize well in polar solvents like water and methanol due to their ionic nature.
  • Ionic Interaction: The presence of the chloride ion Cl plays a crucial role, often enhancing solubility in aqueous solutions.
  • Hydrophobic Regions: The benzyloxy group contributes to non-polar interactions, which may limit solubility in purely non-polar solvents.

A common phenomenon observed is that, as the temperature increases, solubility in most solvents tends to increase due to greater molecular agitation. Additionally, compounds like this one can exhibit varying degrees of solubility at different pH levels:

  1. At lower pH, the cationic form predominates, often increasing solubility in water.
  2. At neutral to higher pH, ionization may decrease, potentially diminishing solubility.

In summary, the solubility of 2-piperidin-1-ium-1-ylethyl N-(2-benzyloxyphenyl)carbamate; chloride can be described as:

  • Highly soluble in polar solvents, particularly water.
  • Potentially less soluble in non-polar solvents.
  • Temperature and pH-dependent.

This solubility profile makes the compound valuable in applications requiring a stable ionic form, rendering it suitable for various chemical reactions and processes.

Interesting facts

Interesting Facts about 2-Piperidin-1-ium-1-ylethyl N-(2-benzyloxyphenyl)carbamate; Chloride

This compound, with its intricate structure, is an excellent representation of how chemistry can combine diverse functional groups to create unique properties. Here are some fascinating aspects about it:

  • Complex Structure: The presence of a piperidin-1-ium ring makes this compound interesting; its cyclic structure can influence both the reactivity and interaction with biological systems.
  • Biological Activity: Compounds like this are often explored for their potential in pharmaceutical applications due to their ability to bind with biological targets due to the presence of the carbamate group.
  • Solubility Considerations: The benzyloxyphenyl moiety may enhance the lipophilicity of the molecule, potentially improving its membrane permeability, which is a critical factor in drug design.
  • Structure-Activity Relationship (SAR): Studying such compounds can provide insights into the structure-activity relationship, crucial for developing more effective therapeutic agents.
  • Research Applications: This compound, like many similar ones in medicinal chemistry, is often investigated for its neuroprotective properties, opening pathways for treatments in neurodegenerative disorders.

To quote a renowned chemist, “Chemistry is the science of transformation,” which reflects perfectly upon molecules like this that undergo significant changes in reactions and biological interactions. The exploration of such compounds can lead to significant breakthroughs in medicinal chemistry and pharmacology, making it a field rich with potential.

Overall, 2-piperidin-1-ium-1-ylethyl N-(2-benzyloxyphenyl)carbamate; chloride certainly encourages researchers to delve deeper into the promising intersection of chemistry and biology.

Synonyms
KP 53
2-Piperidinoethyl o-(benzyloxy)carbanilate hydrochloride
19448-01-2
o-(Benzyloxy)carbanilic acid 2-piperidinoethyl ester hydrochloride
CARBANILIC ACID, o-(BENZYLOXY)-, 2-PIPERIDINOETHYL ESTER, HYDROCHLORIDE
RefChem:333085