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N-(2-Carboxyphenyl)piperidine-1-carboxamide

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Identification
Molecular formula
C13H15NO3
CAS number
18884-36-7
IUPAC name
2-(piperidine-1-carbonyl)benzoic acid
State
State

The compound is typically a solid at room temperature, exhibiting a crystalline structure. It is often used in its solid form for chemical synthesis and analysis.

Melting point (Celsius)
160.50
Melting point (Kelvin)
433.70
Boiling point (Celsius)
451.50
Boiling point (Kelvin)
724.70
General information
Molecular weight
235.26g/mol
Molar mass
235.2620g/mol
Density
1.2997g/cm3
Appearence

N-(2-Carboxyphenyl)piperidine-1-carboxamide appears as a crystalline solid with a white or slightly off-white color. It is generally odorless and forms fine particles when ground.

Comment on solubility

Solubility of 2-(piperidine-1-carbonyl)benzoic acid

2-(piperidine-1-carbonyl)benzoic acid, featuring a piperidine ring and a carboxylic acid functional group, exhibits interesting solubility characteristics. Being a carboxylic acid, it has a tendency to dissolve in polar solvents due to its ability to form hydrogen bonds.

Solubility Characteristics:

  • Polar Solvents: It is likely to be soluble in water and alcohol due to the polar nature of the carboxylic acid group.
  • Non-Polar Solvents: The presence of the hydrophobic piperidine moiety may limit solubility in non-polar solvents.
  • Acid-Base Interactions: Its solubility can be influenced by the pH of the solution, as protonation and deprotonation can affect its overall solubility profile.

In summary, the solubility of 2-(piperidine-1-carbonyl)benzoic acid is primarily dependent on the solvent's polarity and the chemical environment surrounding the compound. Understanding these solubility factors is crucial in applications such as drug formulation and biochemical research.

Interesting facts

Interesting Facts about 2-(piperidine-1-carbonyl)benzoic acid

2-(piperidine-1-carbonyl)benzoic acid is a fascinating compound that showcases the unique interplay between organic chemistry and medicinal applications. Here are some engaging points to understand its significance:

  • Structure and Function: This compound features a benzoic acid group linked to a piperidine ring, creating opportunities for diverse reactions and interactions. The combination of these two structural elements often leads to enhanced biological activity.
  • Biological Relevance: Compounds similar to 2-(piperidine-1-carbonyl)benzoic acid are frequently studied in drug design, particularly for their potential as anti-inflammatory and analgesic agents. These properties make them of interest in pharmacology.
  • Synthesis Pathways: The synthesis of this compound can involve various methods including carboxylation and amide bond formation. Understanding these pathways not only benefits practical chemistry but also enhances theoretical knowledge of reaction mechanisms.
  • Research Focus: As research continues, the modification of the piperidine structure can lead to derivatives with improved efficacy or reduced side effects, making it a critical focus for medicinal chemists.

In summary, 2-(piperidine-1-carbonyl)benzoic acid is not just a simple organic compound; it is a stepping stone towards innovative pharmaceuticals and a rich topic for an aspiring chemist to explore. As highlighted by one prominent researcher, "The potential of small molecules like this should never be underestimated in the quest for new medicines."

Synonyms
o-(Piperidinocarbonyl)benzoic acid
BENZOIC ACID, o-(PIPERIDINOCARBONYL)-
Benzoic acid, 2-(1-piperidinylcarbonyl)-
3M0TMG2SGU
2-(1-piperidinylcarbonyl)Benzoic acid
NSC 175179
BRN 0193956
O-(Piperidinocarbonyl)-benzoic acid
UNII-3M0TMG2SGU
NSC-175179
DTXSID80174218
5-20-02-00474 (Beilstein Handbook Reference)
DTXCID7096709
RefChem:202347
20320-44-9
2-(piperidin-1-ylcarbonyl)benzoic acid
2-(piperidine-1-carbonyl)benzoic acid
MFCD00443957
Oprea1_109173
Oprea1_173583
WLN: T6NTJ AVR BVQ
CBDivE_000515
SCHEMBL16051336
2-(piperidylcarbonyl)benzoic acid
2-(piperidinocarbonyl)benzoic acid
HMS1611G06
NSC175179
AKOS000264038
SB43263
BS-21880
ST001291
SY132465
DB-066132
CS-0212947
EN300-09401
G75993
SR-01000454999
SR-01000454999-1
Z56917375