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2-Pyridylmethanamine

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Identification
Molecular formula
C6H8N2
CAS number
3731-53-1
IUPAC name
2-pyridylmethanamine
State
State

At room temperature, 2-Pyridylmethanamine is generally in a liquid state. It is known for its stability as a liquid under normal conditions, however proper storage away from direct light and air is recommended to prevent oxidation.

Melting point (Celsius)
-20.00
Melting point (Kelvin)
253.15
Boiling point (Celsius)
204.00
Boiling point (Kelvin)
477.15
General information
Molecular weight
108.15g/mol
Molar mass
108.1490g/mol
Density
1.0860g/cm3
Appearence

2-Pyridylmethanamine appears as a colorless to pale yellow liquid. It tends to darken upon exposure to air and light, indicating some sensitivity to oxidation. The liquid is typically clear, but impure samples may appear slightly yellow.

Comment on solubility

Solubility of 2-pyridylmethanamine

2-pyridylmethanamine, also referred to as 2-(pyridin-2-yl)ethanamine, demonstrates notable solubility characteristics that can be categorized based on its chemical structure and functional groups.

Key Points on Solubility:

  • Polar Nature: The presence of the amino group (-NH2) in 2-pyridylmethanamine contributes to its polar nature, enhancing its solubility in polar solvents.
  • Water Solubility: 2-pyridylmethanamine is soluble in water, indicating strong interactions such as hydrogen bonding between the solvent and the solute.
  • Solubility in Organic Solvents: It is also soluble in various organic solvents, including ethanol and methanol, due to its aromatic pyridine ring that can engage in π-π interactions.

Moreover, the solubility can be affected by several factors, including:

  • Temperature: Increased temperatures generally improve solubility.
  • pH Levels: The solubility may vary in response to changes in pH, especially due to the basic nature of the amine group.

In summary, 2-pyridylmethanamine exhibits a distinctive solubility profile, highlighting its capabilities to dissolve in both polar and non-polar environments due to its unique functional groups. This makes it versatile for a range of chemical applications.

Interesting facts

Interesting Facts about 2-Pyridylmethanamine

2-Pyridylmethanamine, also known as 2-(pyridin-2-yl)ethan-1-amine, is an intriguing organic compound within the realm of medicinal and synthetic chemistry. Here are some notable aspects:

  • Biological Roles: This compound has been studied for its potential biological activities, including antibacterial and antifungal properties, making it a candidate for pharmaceutical applications.
  • Functional Group Presence: Featuring both an amine and a pyridine ring, 2-pyridylmethanamine is an example of a compound with diverse functional groups, which can lead to varied reactivities and interactions.
  • Synthesis: It can be synthesized through the alkylation of pyridine derivatives, which showcases the versatility of synthetic methodologies in organic chemistry.
  • Research Applications: Chemical researchers often use this compound in studies related to enzyme inhibition, providing insights into the development of new therapeutic agents.
  • Multi-faceted Utility: Beyond medicinal chemistry, 2-pyridylmethanamine can be utilized in the synthesis of agrochemicals and as a ligand in coordination chemistry, illustrating its wide-ranging applicability.

Overall, the study of 2-pyridylmethanamine illustrates the intersection of organic synthesis and medicinal application, underlining the importance of compounds that can lead to significant advancements in various scientific fields. It serves as a reminder of the vast possibilities that organic chemistry offers!

Synonyms
3731-51-9
2-(Aminomethyl)pyridine
2-Pyridinemethanamine
2-Picolinamine
2-Pyridinemethylamine
2-Pyridylmethylamine
(2-Pyridylmethyl)amine
beta-Picolylamine
NSC 59705
PYRIDINE, 2-AMINOMETHYL-
EINECS 223-090-5
BRN 0108054
2-(aminomethyl) pyridine
DTXSID5063152
5-22-09-00232 (Beilstein Handbook Reference)
2picolylamine
betaPicolylamine
2Picolinamine
2-picolamine
2pyridylmethylamine
2aminomethylpyridine
2Pyridinemethanamine
2Pyridinemethylamine
(2Pyridylmethyl)amine
Pyridine, 2aminomethyl
DTXCID4039314
223-090-5
inchi=1/c6h8n2/c7-5-6-3-1-2-4-8-6/h1-4h,5,7h
2-Picolylamine
pyridin-2-ylmethanamine
2-Aminomethylpyridine
Pyridine, 2-(aminomethyl)-
1-(pyridin-2-yl)methanamine
2-AMINOMETHYL-PYRIDINE
2-pyridinylmethylamine
MFCD00006360
(pyridin-2-yl)methanamine
C-Pyridin-2-yl-methylamine
2-Pyridinylmethanamine
(pyridin-2-ylmethyl)amine
1-pyridin-2-ylmethanamine
XK7252M2PA
CHEBI:81387
NSC-59705
Pyridinemethanamine
pyridylmethylamine
Pyridin-2-Yl-Methanamine
picolinamine
picolylamine
o-Picolylamine
2-picolyl amine
Aminomethylpyridine
aminomethyl pyridine
2-pyridylmethanamine
.beta.-Picolylamine
2-aminomethylpryidine
.alpha.-Picolylamine
2-aminomethyl pyrdine
2-pyridyl-methylamine
2(aminomethyl)pyridine
2-amino methylpyridine
2-aminomethyl pyridine
pyridine-2-methylamine
(2-pyridyl)methanamine
pyridin-2-ylmethylamine
2-(amino)methylpyridine
2-(aminomethyl)pryidine
2-amino methyl pyridine
pyridine-2-ylmethanamine
pyridine-2-ylmethylamine
2-Picolylamine, 99%
(2-pyridinylmethyl)amine
pyridin-2-ylmethyl amine
2-(amino methyl)pyridine
2-(aminomethyl)-pyridine
1-pyridin-2-ylmethaneamine
2-(amino methyl) pyridine
alpha-(Aminomethyl)pyridine
(pyridin-2-ylmethyl)-amine
WLN: T6NJ B1Z
C-pyridine-2-yl-methylamine
UNII-XK7252M2PA
SCHEMBL40328
CHEMBL32189
SCHEMBL2086329
(PYRIDIN-2-YL)METHYLAMINE
NSC59705
STK802385
AKOS000118825
AB00731
BCP9000115
CS-W007488
FP34672
PS-9292
BP-12086
DB-015973
A1161
NS00030176
EN300-19584
2-(Aminomethyl)pyridine 2-Pyridinemethaneamine
C17926
F11236
Q27155325
F2190-0394
Z104474352
2-Picolylamine, for HPLC derivatization, >=98.0% (GC)