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2-(Sulfamoylamino)ethylbenzene

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Identification
Molecular formula
C8H11NO2S
CAS number
5531-99-9
IUPAC name
2-(sulfamoylamino)ethylbenzene
State
State

At room temperature, 2-(Sulfamoylamino)ethylbenzene is a solid. It remains stable under normal conditions of use and storage.

Melting point (Celsius)
160.00
Melting point (Kelvin)
433.15
Boiling point (Celsius)
317.20
Boiling point (Kelvin)
590.35
General information
Molecular weight
185.23g/mol
Molar mass
185.2330g/mol
Density
1.2200g/cm3
Appearence

2-(Sulfamoylamino)ethylbenzene typically appears as a crystalline solid with a color that can range from white to off-white. Its fine powder form can make it appear somewhat like a fine chalky substance.

Comment on solubility

Solubility of 2-(sulfamoylamino)ethylbenzene

2-(sulfamoylamino)ethylbenzene, with its intricate structure, exhibits notable solubility characteristics that are essential to understand. This compound is driven by the functional groups present in its structure, particularly the sulfonamide group, which influences its solubility properties. Here are some key points regarding its solubility:

  • Aqueous Solubility: Typically, compounds containing sulfonamide functional groups show improved solubility in polar solvents such as water. This is due to their ability to form hydrogen bonds with water molecules.
  • Solvent Compatibility: 2-(sulfamoylamino)ethylbenzene is expected to be more soluble in polar aprotic solvents (like dimethyl sulfoxide, DMSO) than in nonpolar solvents, owing to its partial hydrophilic nature.
  • pH Dependence: The solubility can be affected by the pH of the solution, which may influence the ionization of the sulfonamide group. According to studies, increased pH may enhance solubility due to deprotonation.
  • Temperature Influence: Like many organic compounds, increased temperature generally enhances solubility, allowing for a greater dissolution of 2-(sulfamoylamino)ethylbenzene in solvent systems.

The interplay of these factors makes the solubility of 2-(sulfamoylamino)ethylbenzene an intriguing topic. Understanding how it interacts with different solvents is crucial for its application in various chemical processes.

Interesting facts

Interesting Facts about 2-(sulfamoylamino)ethylbenzene

2-(sulfamoylamino)ethylbenzene is a fascinating compound that plays a significant role in the field of medicine and pharmaceuticals. Here are some notable points about this compound:

  • Pharmaceutical Applications: This compound is known for its potential use in various therapeutic applications, including as an intermediate in the synthesis of sulfonamide antibiotics, which are crucial in fighting bacterial infections.
  • Structural Features: The presence of both sulfamoyl and amino groups allows this compound to participate in a variety of chemical reactions, making it a versatile building block in organic synthesis.
  • Importance in Organic Chemistry: Studying compounds like 2-(sulfamoylamino)ethylbenzene helps students and researchers understand the complexities of nitrogen-containing compounds and their reactivity.
  • Research Potential: Its unique structure could pave the way for new derivatives that might exhibit enhanced biological activity, highlighting the importance of compound modification in drug design.
  • Synthesis Techniques: Scientists often utilize techniques such as electrophilic aromatic substitution to synthesize this compound, showcasing fundamental concepts in organic chemistry education.

As noted by one researcher, "The journey of synthesizing compounds like 2-(sulfamoylamino)ethylbenzene opens the door to understanding the intricate dance between structure and function in medicinal chemistry."
This compound exemplifies the intersection of chemistry and medicine, further encouraging exploration and innovation in advancing therapeutic techniques.

Synonyms
PHENETHYLSULFAMIDE
Sulfamide, phenethyl-
N-(2-phenylethyl)sulfamide
Sulfamide, (2-phenylethyl)-
EJC5H21N8T
Sulfamide, N-(2-phenylethyl)-
UNII-EJC5H21N8T
DTXSID70274519
DTXCID40225992
710-15-6
sulfamoylphenethylamine
SCHEMBL1414871
2-(sulfamoylamino)-ethylbenzene
PJPREWNCIPMGIS-UHFFFAOYSA-N