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Alprenolol hydrobromide

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Identification
Molecular formula
C13H19BrFNO
CAS number
2854-40-2
IUPAC name
2-(tert-butylamino)-1-(3-fluorophenyl)ethanol;hydrobromide
State
State

Alprenolol hydrobromide is typically a solid at room temperature. It is commonly used in its crystalline powder form for medicinal and laboratory applications.

Melting point (Celsius)
115.00
Melting point (Kelvin)
388.15
Boiling point (Celsius)
347.00
Boiling point (Kelvin)
620.15
General information
Molecular weight
334.25g/mol
Molar mass
334.2540g/mol
Density
1.3000g/cm3
Appearence

Alprenolol hydrobromide typically appears as a white or off-white crystalline powder. Its appearance can sometimes exhibit slight variations depending on the presence of impurities or specific crystal formation conditions.

Comment on solubility

Solubility of 2-(tert-butylamino)-1-(3-fluorophenyl)ethanol;hydrobromide

The solubility of 2-(tert-butylamino)-1-(3-fluorophenyl)ethanol;hydrobromide in various solvents can be quite insightful for its practical applications in pharmaceutical formulations.

  • Water Solubility: This compound is expected to have moderate solubility in water due to its hydrobromide form. The presence of the hydrobromide moiety enhances solubility through ionic interactions.
  • Alcohol Solubility: It may exhibit good solubility in polar organic solvents such as methanol and ethanol because of its polar functional groups.
  • Non-Polar Solvents: Conversely, solubility in non-polar solvents is likely to be low due to the presence of hydrophilic features within the molecule.

Overall, the solubility profile is influenced by:

  1. Ionization: The protonation state and formation of salts can significantly enhance solubility.
  2. Solvent Polarity: The choice of solvent plays a crucial role—polar solvents typically dissolve polar solutes.
  3. Temperature: Generally, an increase in temperature can improve solubility for many compounds.

In conclusion, while predictions can be made about its solubility based on its structure, empirical testing is vital for accurate determination in specific conditions. Understanding these solubility characteristics is essential for optimizing its use in various chemical and medicinal applications.

Interesting facts

Interesting Facts About 2-(tert-butylamino)-1-(3-fluorophenyl)ethanol; hydrobromide

This compound, known as 2-(tert-butylamino)-1-(3-fluorophenyl)ethanol hydrobromide, is a fascinating entry point into the world of medicinal chemistry. Its unique structural components offer intriguing prospects in biological applications and pharmacology.

Key Characteristics

  • Pharmacological Potential: The presence of the tert-butylamino group suggests potential for interesting interactions with biological pathways, opening avenues for therapeutic development.
  • Fluorine Influence: The incorporation of a 3-fluorophenyl moiety can enhance the compound's lipophilicity, which often translates to improved membrane permeability for drug design.
  • Hydrobromide Form: As a hydrobromide salt, it may exhibit different solubility and stability profiles, which can be vital for pharmaceutical formulations.

Scientific Relevance

The synergy between its amino and hydroxyl functional groups positioned on the ethanol backbone allows for a range of intramolecular interactions. Such interactions may be essential for binding to specific targets within biological systems. As stated in a recent review, "the amino alcohols represent a versatile scaffold for the development of novel therapeutics."

Research and Development

Its synthesis and characterization are critical areas of study, providing insights into:

  • Drug design methodologies
  • Mechanisms of action in the body
  • Potential side effects or pharmacokinetics

In conclusion, 2-(tert-butylamino)-1-(3-fluorophenyl)ethanol; hydrobromide is more than just a chemical compound; it's a bridge connecting synthetic chemistry and therapeutic innovation. As we unravel its properties and potential, it underscores the dynamic interplay between structure and function in chemical entities.

Synonyms
582-40-1
2-tert-Butylamino-1-(3-fluorophenyl)ethanol hydrobromide
Ethanol, 2-tert-butylamino-1-(3-fluorophenyl)-, hydrobromide
alpha-(tert-Butylaminomethyl)-3-fluorobenzyl alcohol hydrobromide
BENZYL ALCOHOL, alpha-(tert-BUTYLAMINOMETHYL)-3-FLUORO-, HYDROBROMIDE
DTXSID30973758
2-(tert-Butylamino)-1-(3-fluorophenyl)ethan-1-ol--hydrogen bromide (1/1)