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Labetalol

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Identification
Molecular formula
C19H24N2O
CAS number
36894-69-6
IUPAC name
2-(tert-butylamino)-1-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)ethanone
State
State

At room temperature, Labetalol is typically found in its solid-state form as a crystalline powder, particularly when isolated as the hydrochloride salt.

Melting point (Celsius)
179.00
Melting point (Kelvin)
452.00
Boiling point (Celsius)
398.20
Boiling point (Kelvin)
671.35
General information
Molecular weight
328.42g/mol
Molar mass
328.4230g/mol
Density
1.3080g/cm3
Appearence

Labetalol hydrochloride appears as a white or off-white crystalline powder. It is odorless and has a bitter taste. The compound is often used in its hydrochloride salt form for medical applications.

Comment on solubility

Solubility of 2-(tert-butylamino)-1-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)ethanone

The solubility of 2-(tert-butylamino)-1-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)ethanone can be quite intriguing due to its complex structure. Here are some key points to consider:

  • Polarity: The presence of the tert-butylamine group tends to increase the overall hydrophobic character of the compound, which may affect its solubility in aqueous solvents.
  • Solvent Dependence: This compound is likely more soluble in organic solvents like methanol, ethanol, and dimethyl sulfoxide (DMSO) due to the lack of strong polar functional groups.
  • Temperature Influence: As with many organic molecules, an increase in temperature may enhance solubility in non-polar solvents.
  • Potential for Intermolecular Interactions: The aromatic rings may engage in π-π stacking or hydrophobic interactions, influencing its solubility behavior in various environments.

In summary, the solubility of 2-(tert-butylamino)-1-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)ethanone is influenced by its chemical structure, with a tendency towards solubility in organic solvents over aqueous solutions. This makes it essential to consider the specific solvent environment when working with this compound.

Interesting facts

Interesting Facts about 2-(tert-butylamino)-1-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)ethanone

This compound is a fascinating example of a complex organic molecule that often piques the interest of chemists and pharmacologists alike. With its unique structural framework, it plays a significant role in medicinal chemistry, particularly in the development of therapeutic agents.

Structural Highlights

  • Diversity in Structure: The compound's structure includes a combination of amine and ketone functional groups, making it a versatile candidate for various chemical reactions.
  • Presence of Dihydrobenzo: The inclusion of the 5,6-dihydrobenzo[b][1]benzazepin moiety adds to its complexity and may enhance its biological activity, contributing to the potential for developing new drugs.
  • Tertiary Amino Group: The tert-butylamino group provides steric hindrance that may influence the compound's interactions with biological targets, making it an interesting subject for research into receptor binding.

Biological Significance

Compounds similar to this one are explored for their potential in treating various neurological and psychiatric disorders. They may influence neurotransmitter systems, which opens avenues for pharmacological investigation.

Research Potential

Ongoing studies may uncover:

  • Novel mechanisms of action in the central nervous system
  • Synergistic effects when combined with other therapeutic agents
  • New pathways for developing antidepressants or antipsychotics

As chemists continue to investigate this compound, it serves as a reminder of the beauty and complexity inherent in organic chemistry, where even a slight modification can have significant implications for biological activity. As one researcher aptly put it, *"The path to discovering a new drug starts with the intricate dance of molecular interactions."* This compound epitomizes that journey.