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Trimeprazine hydrochloride

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Identification
Molecular formula
C18H23ClN2OS
CAS number
4330-58-7
IUPAC name
2-(tert-butylamino)-1-phenothiazin-10-yl-ethanone;hydrochloride
State
State

Trimeprazine hydrochloride is typically found in a solid state at room temperature.

Melting point (Celsius)
210.00
Melting point (Kelvin)
483.15
Boiling point (Celsius)
342.30
Boiling point (Kelvin)
615.45
General information
Molecular weight
435.98g/mol
Molar mass
435.9750g/mol
Density
1.1970g/cm3
Appearence

Trimeprazine hydrochloride appears as an off-white to pale yellow crystalline powder. It is hygroscopic and sensitive to light, requiring storage in a cool, dry place away from direct sunlight.

Comment on solubility

Solubility of 2-(tert-butylamino)-1-phenothiazin-10-yl-ethanone;hydrochloride

The solubility of 2-(tert-butylamino)-1-phenothiazin-10-yl-ethanone;hydrochloride can be significantly influenced by its ionic nature, as it is a hydrochloride salt. This compound typically exhibits the following solubility characteristics:

  • Water Solubility: As a hydrochloride, it is generally soluble in water due to the presence of the ionic Cl- ion, enhancing its dissolution in polar solvents.
  • Organic Solubility: The presence of the phenothiazine moiety can contribute to varying degrees of solubility in organic solvents, but its overall solubility might be limited compared to its salt form.
  • Temperature Effects: Like many compounds, its solubility may increase with temperature; therefore, heating may aid in dissolving the compound in a given solvent.
  • pH Dependence: The solubility can also be affected by the pH of the solution; at different pH levels, the protonation states may change, leading to variations in solubility.

In summary, the solubility of this compound is expected to be high in aqueous solutions because of its hydrochloride form, while solubility in organic solvents may require careful consideration of the solvent properties and environmental factors.

Interesting facts

Interesting Facts about 2-(tert-Butylamino)-1-phenothiazin-10-yl-ethanone; Hydrochloride

This compound represents a fascinating intersection of medicinal chemistry and organic synthesis, with meaningful applications in the realm of pharmacology. The presence of the phenothiazine moiety is particularly significant, as compounds of this class have been widely utilized in therapeutic contexts, especially as antipsychotic medications.

Key Features

  • Diverse Applications: Known for its efficacy, this compound may exhibit neuroleptic properties and could be explored for its potential in treating mental health disorders.
  • Stability and Solubility: The hydrochloride form of the compound enhances its stability and solubility, making it more suitable for pharmaceutical formulations.
  • Structure-Activity Relationship: Researchers continue to study how structural variations, such as the tert-butylamino group, influence biological activity, providing insights into drug design.

The specificity of this compound's action, combined with its structural complexity, makes it a subject of ongoing research interest. As noted by many chemists, “Medicine is a science of uncertainty, and an art of probability.” This statement resonates particularly well in the context of compounds like this, where slight modifications can lead to significantly different pharmacodynamic outcomes.

Research Implications

Further studies may elucidate this compound's mechanism of action and therapeutic profile, potentially leading to the development of novel treatments:

  • Investigating its effect on various neurotransmitter systems.
  • Assessing its safety and efficacy through clinical trials.
  • Exploring potential combination therapies with other psychoactive agents.

In summary, 2-(tert-butylamino)-1-phenothiazin-10-yl-ethanone; hydrochloride reflects the intricate and dynamic nature of medicinal chemistry, where innovative thinking and a rigorous scientific approach can lead to groundbreaking advancements in health care.

Synonyms
29722-83-6
KETONE, tert-BUTYLAMINOMETHYL PHENOTHIAZIN-10-YL, HYDROCHLORIDE
Phenothiazine, 10-(2-tert-butylaminoacetyl)-, hydrochloride
DTXSID90183876
RefChem:350501
DTXCID30106367