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Tolazoline hydrochloride

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Identification
Molecular formula
C10H12N2·HCl
CAS number
59-97-2
IUPAC name
2-tetralin-1-yl-4,5-dihydro-1H-imidazole;hydrochloride
State
State

The compound, Tolazoline hydrochloride, is typically in a solid state at room temperature, presenting as a crystalline powder.

Melting point (Celsius)
155.00
Melting point (Kelvin)
428.15
Boiling point (Celsius)
228.00
Boiling point (Kelvin)
501.15
General information
Molecular weight
196.69g/mol
Molar mass
196.6880g/mol
Density
0.9927g/cm3
Appearence

The compound is typically found as a white or off-white crystalline powder. It is highly soluble in water and displays hygroscopic properties, meaning it can absorb moisture from the air.

Comment on solubility

Solubility of 2-tetralin-1-yl-4,5-dihydro-1H-imidazole; hydrochloride

The solubility of 2-tetralin-1-yl-4,5-dihydro-1H-imidazole; hydrochloride is influenced by several key factors:

  • Polarity: Generally, the compound is considered polar due to the presence of the imidazole ring, which can form hydrogen bonds with water.
  • Chloride Salt Formation: As a hydrochloride salt, the solubility is enhanced compared to its free base form, making it more soluble in aqueous environments.
  • Temperature Dependency: Increased temperatures can further increase solubility, allowing more of the compound to dissolve in a given volume of solvent.
  • Solvent Specificity: While it shows good solubility in water, organic solvents might yield different solubility profiles; thus, the choice of solvent is crucial.

In summary, the solubility of this compound is characterized by a balance of polarity, salt formation, and temperature, making it relatively soluble in aqueous solutions. As with many chemicals, it's essential to consider the solvent environment when assessing dissolution behavior.

Interesting facts

Interesting Facts about 2-tetralin-1-yl-4,5-dihydro-1H-imidazole;hydrochloride

This compound is quite intriguing due to its unique structure and potential applications. 2-tetralin-1-yl-4,5-dihydro-1H-imidazole is a derivative of imidazole, which is a five-membered heterocyclic compound. Here are some noteworthy aspects of this compound:

  • Structural Significance: The presence of a tetralin moiety introduces a bicyclic framework, which can influence the compound’s interactions with biological systems.
  • Biological Relevance: Compounds containing imidazole rings are often found in pharmacology, playing roles in various biological processes, including enzyme activities and receptor binding.
  • Salt Formation: Being in hydrochloride form, it enhances solubility and stability, making it easier for pharmaceuticals to be formulated for a specific route of administration.
  • Versatile Derivatives: Imidazole derivatives, similar to this compound, have been developed into numerous drugs, including antifungal agents and anti-inflammatory medications.
  • Research Potential: Compounds like this one are of interest in organic synthesis and may serve as intermediates for developing new compounds with desired biological activities.

The unique combination of tetralin and imidazole structures lends itself to innovative research possibilities and the discovery of new therapeutic agents. As quoted in the realm of medicinal chemistry, “The discovery of new drugs is a journey into the unknown, where unexpected compounds can yield transformative therapies.”

Given the evolving nature of research, the full potential of 2-tetralin-1-yl-4,5-dihydro-1H-imidazole; hydrochloride remains a fascinating topic for further exploration.

Synonyms
Tetrahydrozoline hydrochloride
522-48-5
Tetrahydrozoline HCl
Tyzanol hydrochloride
2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole hydrochloride
Yxin
Tetryzoline HCl
UNII-0YZT43HS7D
EINECS 208-329-3
0YZT43HS7D
NSC-757339
DTXSID7045316
AI3-50165
2-(1,2,3,4-Tetrahydro-1-naphthyl)-2-imidazoline hydrochloride
2-(1,2,3,4-Tetrahydro-1-naphthyl)-2-imidazoline monohydrochloride
1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, monohydrochloride
CHEBI:9492
DTXCID5025316
Tetrahydrozoline hydrochloride [USP]
NSC 757339
2-IMIDAZOLINE, 2-(1,2,3,4-TETRAHYDRO-1-NAPHTHYL)-, HYDROCHLORIDE
Tetrahydrozoline hydrochloride (USP)
TETRYZOLINE HYDROCHLORIDE (MART.)
TETRYZOLINE HYDROCHLORIDE [MART.]
TETRAHYDROZOLINE HYDROCHLORIDE (USP-RS)
TETRAHYDROZOLINE HYDROCHLORIDE [USP-RS]
TETRYZOLINE HYDROCHLORIDE (EP MONOGRAPH)
TETRYZOLINE HYDROCHLORIDE [EP MONOGRAPH]
TETRAHYDROZOLINE HYDROCHLORIDE (USP MONOGRAPH)
TETRAHYDROZOLINE HYDROCHLORIDE [USP MONOGRAPH]
Redness Reliever
T-raojo
Equate Eye Drops
Eye Drops Regular
Murine Plus 2
Dg Health Original
Circle K Eye Drops
Tetrahydrozoline HCI
Premier Value Original
DG Original Eye Drops
Equate Redness Reliever
Visine Red Eye Comfort
Sound Body Original Eye
Careall Eyedrops Original
Family Care Original Eye
Freds Original Eye Drops
Equate Original Eye Drops
Leader Original Eye Drops
Lil Drug Store Eye Drops
Optical Original Eye Drops
Assured Original Relief Eye
Cvs Redness Relief Original
Tetrahyrozoline hydrochloride
Goodsense Original Eye Drops
Walgreens Original Eye Drops
Tetrahydrozoline HCl 0.05%
Rite Aid Original Sterile Eye
Walgreens Sterile Original Eye
GoodSense Original Formula Eye
Dg Health Sterile Redness Relief
Winco Original Formula Eye Drops
Leader Original Formula Eye Drops
Quality Choice Original Eye Drops
Shopko Original Formula Eye Drops
TopCare Health Original Eye Drops
Circle K Eye DropsRedness Reliever
Sunmark Eye Drops Original Formula
GoodSense Eye Drops Original Formula
Walgreens Sterile Original Eye Drops
Lil Drug Store Eye DropsRedness Reliever
Rugby Tetrahydrozoline Ophthalmic Solution
Foster and Thrive Original Formula Eye Drops
Preferred Plus Pharmacy Redness Relief Eye Drops
Walgreens Eye Drops Original 15mL and twin pack
Family Wellness Original Redness Relief Eye Drops
Good Neighbor Pharmacy Eye Drops Original Formula
208-329-3
Tetryzoline hydrochloride
Tyzine
Visine
Murine Plus
Vasopos
Tetrahydrozoline (hydrochloride)
MFCD00058029
MLS000069739
1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-,monohydrochloride
522-48-5 (HCl)
SMR000058219
2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole;hydrochloride
1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, hydrochloride (1:1)
Rhinopront
SR-01000000161
tetrahydrozoline monohydrochloride
Prestwick_1025
Tyzine (TN)
Tetryzolini hydrochloridum
Opera_ID_1724
NCGC00016485-01
CAS-522-48-5
SCHEMBL25702
MLS000079025
MLS001146954
MLS002222291
MLS002548902
SPECTRUM1500567
HY-B0556AR
2-tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride
CHEMBL1200413
HY-B0556A
BJORNXNYWNIWEY-UHFFFAOYSA-N
HMS1570K17
HMS1921C21
Pharmakon1600-01500567
BCP15857
Tox21_110450
Tox21_501137
CCG-39268
MSK161559
NSC757339
2-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)-4,5-DIHYDRO-1H-IMIDAZOLE HCL
AKOS015899540
Tox21_110450_1
AC-1110
FT28149
LP01137
NC00484
Tetrahydrozoline hydrochloride, >=98%
NCGC00016018-10
NCGC00094403-01
NCGC00094403-02
NCGC00094403-03
NCGC00094403-04
NCGC00094403-05
NCGC00261822-01
AS-15973
SY107281
Tetrahydrozoline hydrochloride (JAN/USP)
TETRYZOLINE HYDROCHLORIDE [WHO-DD]
TETRAHYDROZOLINE HYDROCHLORIDE [MI]
Tetrahydrozoline (hydrochloride) (Standard)
TETRAHYDROZOLINE HYDROCHLORIDE [JAN]
EU-0101137
NS00080036
S4043
SW197098-3
T3148
TETRAHYDROZOLINE HYDROCHLORIDE [VANDF]
VU0239726-5
D01023
EN300-119536
T 4264
SR-01000000161-2
SR-01000000161-8
TETRAHYDROZOLINE HYDROCHLORIDE [ORANGE BOOK]
Q27237368
Z1695906783
2-(1,2,3,4-Tetrahydro-1-naphthyl)-2-imidazolinehydrochloride
2-(1,2,3,4-Tetrahydro-1-naphthyl)-4,5-dihydro-1H-imidazole Hydrochloride
2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazolehydrochloride
2-[(1RS)-1,2,3,4-Tetrahydronaphthalen-1-yl]-4,5-dihydro-1H-imidazole hydrochloride
4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole Hydrochloride
4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole monohydrochloride
Tetrahydrozoline hydrochloride, European Pharmacopoeia (EP) Reference Standard
Tetrahydrozoline hydrochloride, United States Pharmacopeia (USP) Reference Standard
4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole hydrochloride;Murine plus;Soothe
Tetrahydrozoline hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material