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2-(trifluoromethyl)benzimidazole-5-amine

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Identification
Molecular formula
C8H6F3N3
CAS number
90005-55-1
IUPAC name
2-(trifluoromethyl)-3H-benzimidazol-5-amine
State
State

At room temperature, 2-(trifluoromethyl)-3H-benzimidazol-5-amine is generally found in a solid state. This makes it suitable for handling in standard laboratory environments, where it maintains stability and does not require any special storage conditions such as refrigeration or pressure control.

Melting point (Celsius)
204.00
Melting point (Kelvin)
477.15
Boiling point (Celsius)
305.00
Boiling point (Kelvin)
578.15
General information
Molecular weight
203.16g/mol
Molar mass
203.1580g/mol
Density
1.4600g/cm3
Appearence

This compound is typically a white to off-white crystalline solid. The exact shade and form can vary slightly depending on purity and specific crystal structure of the batch.

Comment on solubility

Solubility of 2-(trifluoromethyl)-3H-benzimidazol-5-amine

The solubility of 2-(trifluoromethyl)-3H-benzimidazol-5-amine can be influenced by several factors due to its unique chemical structure:

  • Polarity: The presence of the trifluoromethyl group contributes to the polarity of the molecule. Compounds with similar polar characteristics generally have higher solubility in polar solvents, such as water.
  • Hydrophobic Interactions: The benzimidazole ring may exhibit hydrophobic interactions, affecting solubility in non-polar solvents. This could lead to a disparity in solubility when considering different solvents.
  • Hydrogen Bonding: The amine group can participate in hydrogen bonding, which might enhance solubility in polar solvents. The extent of these interactions will be crucial in evaluating solubility.
  • Temperature Impact: As with many chemical compounds, temperature can significantly affect solubility. Increased temperature typically enhances solubility for many crystalline solids.

In summary, the solubility of 2-(trifluoromethyl)-3H-benzimidazol-5-amine is likely to be solvent-dependent, exhibiting higher solubility in polar solvents while demonstrating some degree of hydrophobic characteristics when in non-polar environments. Understanding these factors is essential for predicting its behavior in various chemical processes.

Interesting facts

Interesting Facts About 2-(Trifluoromethyl)-3H-benzimidazol-5-amine

2-(Trifluoromethyl)-3H-benzimidazol-5-amine is a fascinating compound that showcases the intriguing interplay of halogens and heterocyclic chemistry. Here are some compelling aspects of this compound:

  • Pharmaceutical Potential: Compounds featuring the benzimidazole structure are known for their valuable biological activities. This particular compound's trifluoromethyl group enhances electron-withdrawing properties, potentially leading to increased potency in medicinal applications.
  • Applications in Agrochemicals: The presence of fluorine atoms in organic compounds often translates to improved stability and bioactivity. This characteristic makes 2-(trifluoromethyl)-3H-benzimidazol-5-amine a candidate for use in design as a pesticide or herbicide.
  • Research Significance: The incorporation of trifluoromethyl groups into chemical frameworks has been a hot topic in organic synthesis, allowing researchers to explore novel pathways leading to innovative materials or pharmaceuticals.
  • Reactivity: The unique structure of this compound provides various points of reactivity. Researchers may utilize it as a precursor for synthesizing more complex molecules, pushing the boundaries of synthetic chemistry.
  • Biochemistry Connections: Benzimidazole derivatives are often linked to inhibition mechanisms in certain enzymes. The exploration of this compound could contribute to understanding enzyme kinetics and inhibition in biochemical pathways.

The exploration of compounds like 2-(trifluoromethyl)-3H-benzimidazol-5-amine demonstrates the ongoing quest for innovation within the fields of chemistry and pharmacology. As researchers continue to investigate this intriguing molecule, its full potential in various applications may soon unfold.

Synonyms
5-Amino-2-(trifluoromethyl)benzimidazole
1H-Benzimidazol-5-amine, 2-(trifluoromethyl)-
BRN 0959064
BENZIMIDAZOLE, 5-AMINO-2-(TRIFLUOROMETHYL)-
DTXSID00190172
DTXCID10112663
625-229-9
3671-66-7
2-(Trifluoromethyl)-1H-benzo[d]imidazol-5-amine
2-(trifluoromethyl)-3H-benzimidazol-5-amine
2-(trifluoromethyl)-1H-1,3-benzodiazol-5-amine
2-(trifluoromethyl)-1H-benzimidazol-5-amine
5-amino-2-(trifluoromethyl)-1h-benzimidazole
MFCD01632182
5-amino-2-trifluoromethylbenzimidazole
2-(trifluoromethyl)-1h-benzimidazol-6-amine
71N
2-(trifluoromethyl)benzimidazole-5-ylamine
2-Trifluoromethyl-3H-benzoimidazol-5-ylamine
ChemDiv3_006760
SCHEMBL521212
CHEMBL1625689
HMS1492D06
HMS1692J13
ALBB-006239
BBL008376
STK501691
XH0133
2-Trifluoromethyl-5-aminobenzimidazole
AKOS000104139
AKOS000302387
AS-8895
CCG-120244
IDI1_024670
NCGC00245304-01
2-trifluoromethyl-1h-benzoimidazol-5-ylamine
2-trifluoromethyl-3H-benzimidazol-5-ylamine
CS-0079601
2-(trifluoromethyl)-1H-benzimidazole-6-amine
2-trifluoromethyl-3 h-benzoimidazol-5-ylamine
EN300-31610
5-Amino-2-(trifluoromethyl)benzimidazole, 96%
D74073
5-Amino-2-(trifluoromethyl)benzimidazole dihydrochloride