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2-(trifluoromethyl)benzoic acid

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Identification
Molecular formula
C8H5F3O2
CAS number
433-97-6
IUPAC name
2-(trifluoromethyl)benzoic acid
State
State
At room temperature, 2-(trifluoromethyl)benzoic acid is typically in a solid state. It appears as a stable, dry powder with white crystalline structures. The compound is stable under normal conditions, but should be handled carefully to avoid absorption through skin contact or inhalation in powdered form.
Melting point (Celsius)
108.00
Melting point (Kelvin)
381.15
Boiling point (Celsius)
197.00
Boiling point (Kelvin)
470.15
General information
Molecular weight
190.12g/mol
Molar mass
190.1170g/mol
Density
1.4398g/cm3
Appearence

2-(Trifluoromethyl)benzoic acid appears as a white crystalline solid. The crystals are often fine and can appear glossy under light. It is stable when dry and can emit a strong odor typical of many aromatic compounds when impure.

Comment on solubility

Solubility of 2-(trifluoromethyl)benzoic acid

2-(trifluoromethyl)benzoic acid, with the chemical formula C8H5F3O2, exhibits interesting solubility properties that are influenced by its molecular structure. This compound is known to be:

  • Poorly soluble in water: The presence of the trifluoromethyl group strongly affects solubility due to **hydrophobic** characteristics, leading to limited interactions with water molecules.
  • More soluble in organic solvents: Compounds like this are typically more soluble in non-polar or weakly polar organic solvents such as ethyl acetate or dimethyl sulfoxide (DMSO).
  • Affected by pH: The solubility may vary with changes in pH, particularly in acidic or basic conditions that could lead to ionization or deprotonation of the carboxylic acid group.

In summary, while 2-(trifluoromethyl)benzoic acid shows **limited solubility** in water, its solubility increases in organic media, which highlights the significant impact of molecular composition on solubility behavior.

Interesting facts

Interesting Facts about 2-(Trifluoromethyl)benzoic Acid

2-(Trifluoromethyl)benzoic acid, often referred to in the scientific community as a unique aromatic compound, boasts numerous intriguing properties and applications. Here are some fascinating aspects to consider:

  • Unique Fluorine Substitution: The trifluoromethyl group (-CF3) is noted for significantly enhancing the lipophilicity of organic compounds, making 2-(trifluoromethyl)benzoic acid an interesting candidate in drug development and material science.
  • Role in Synthesis: This compound serves as a valuable building block in organic synthesis, enabling chemists to construct larger and more complex molecules. It is a key component in the production of pharmaceuticals and agrochemicals.
  • Environmental Considerations: The incorporation of fluorine atoms can alter a compound's environmental persistence. Understanding the metabolic pathways and environmental impacts of such fluorinated compounds is crucial in ecotoxicology.
  • Research Applications: 2-(Trifluoromethyl)benzoic acid is frequently studied for its effects in various biological systems, revealing insights into how modifications in molecular structure can influence biological activity.
  • Analytical Chemistry: Scientists employ this compound in analytical methods such as chromatography, where its unique properties aid in the separation and identification of other chemical substances.

As you explore the multifaceted world of chemical compounds, 2-(trifluoromethyl)benzoic acid stands out as a vibrant example of how subtle changes in molecular structure can lead to vast differences in behavior and utility. Truly, it embodies the creativity and innovation inherent in chemical research!

Synonyms
2-(Trifluoromethyl)benzoic acid
433-97-6
2-Trifluoromethylbenzoic acid
o-Trifluoromethylbenzoic acid
alpha,alpha,alpha-Trifluoro-o-toluic acid
Benzoic acid, 2-(trifluoromethyl)-
MFCD00002476
2-TFMBA
trifluoromethylbenzoic acid
0R1CK7MZUA
o-(trifluoroformyl)benzoic acid
o-(trifluoromethyl)benzoic acid
2-(trifluoroformyl)benzoic acid
ortho-(trifluoromethyl)benzoic acid
EINECS 207-093-9
NSC 88326
NSC-88326
.alpha.,.alpha.,.alpha.-Trifluoro-o-toluic acid
CHEBI:60694
DTXSID90870537
2-Carboxybenzotrifluoride
137938-95-5
O-TOLUIC ACID, .ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-
o-CARBOXYBENZOTRIFLUORIDE
UNII-0R1CK7MZUA
2-trifluoromethyl benzoic acid
2-(Trifluoromethyl)benzoicAcid
o-Toluic acid, a,a,a-trifluoro- (6CI,7CI,8CI); 2-(Trifluoromethyl)benzoic acid; NSC 88326; o-(Trifluoromethyl)benzoic acid; a,a,a-Trifluoro-o-toluic acid
BENZOIC ACID,(TRIFLUOROMETHYL)-
Enamine_005364
NCIOpen2_001264
o-trifluoromethyl-benzoic acid
SCHEMBL221518
2-trifluoromethyl-benzoic acid
ortho-trifluormethylbenzoic acid
ortho-trifluoromethylbenzoic acid
DTXCID10818254
JPCUZPKBLYUQRD-UHFFFAOYSA-N
HMS1409D18
NSC88326
AC7509
STK946190
AKOS000118808
2-(Trifluoromethyl)benzoic acid, 98%
AC-2625
BS-4039
CS-W015913
SY002327
DB-023811
DB-030751
NS00043355
T1302
EN300-17349
O-TOLUIC ACID, ALPHA,ALPHA,ALPHA-TRIFLUORO-
Q27128431
Z56922112
F2191-0057
207-093-9