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Naltrexone

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Identification
Molecular formula
C20H23NO4
CAS number
16590-41-3
IUPAC name
22-(cyclopropylmethyl)-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5,7,9,15,17,19(25)-heptaene-2,16-diol
State
State

At room temperature, Naltrexone is typically a solid in the form of a crystalline powder. It is stable under normal conditions and is used primarily in its solid, powdered form for pharmaceutical applications.

Melting point (Celsius)
168.00
Melting point (Kelvin)
441.20
Boiling point (Celsius)
762.80
Boiling point (Kelvin)
1 035.90
General information
Molecular weight
341.42g/mol
Molar mass
341.4160g/mol
Density
1.3101g/cm3
Appearence

Naltrexone hydrochloride typically appears as a white to slightly off-white crystalline powder. It is odorless and its form allows for easy dissolution in water and other solvents used in medical formulations.

Comment on solubility

Solubility of 22-(cyclopropylmethyl)-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5,7,9,15,17,19(25)-heptaene-2,16-diol (C20H23NO4)

The solubility of this complex compound, C20H23NO4, is influenced by several structural factors that are paramount in determining how well it dissolves in various solvents. Here are some key points regarding its solubility:

  • Polar vs. Non-Polar Solvents: Due to the presence of the hydroxyl (-OH) groups in its structure, this compound is likely to exhibit some solubility in polar solvents, such as water and alcohols. The ability to form hydrogen bonds typically enhances solubility.
  • Structural Complexity: The intricate polycyclic structure may create steric hindrance that can affect the overall accessibility of the molecule to solvent molecules, potentially leading to lower solubility compared to simpler compounds.
  • Influence of Functional Groups: The 14-oxa and 11,22-diaza aspects introduce heteroatoms that can significantly alter interactions with solvents. Compounds with such functionalities often display varied solubility profiles depending on their environment.
  • Temperature Dependency: As with many organic compounds, solubility may increase with temperature, suggesting that higher temperatures could enhance dissolution rates for this complex molecule.
  • Combination of Factors: Ultimately, solubility is contingent upon a combination of factors, including molecular weight, structural complexity, and the nature of the solvent. As stated, "solubility is a dance between structure and environment."

In summary, the solubility of C20H23NO4 is an intricate interplay of its functional groups and structural features, leading to a potentially variable solubility profile depending on the conditions applied.

Interesting facts

Interesting Facts about 22-(Cyclopropylmethyl)-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5,7,9,15,17,19(25)-heptaene-2,16-diol

This unique compound showcases the fascinating world of chemical diversity and molecular architecture. Here are some intriguing insights:

  • Structural Complexity: The compound is an example of a highly intricate polycyclic structure, which features a series of interconnected cyclic systems. Such complex architectures are often key in the development of novel drugs and materials.
  • Potential Applications: Compounds of this nature are often explored for their potential in pharmaceutical applications due to their unique features. Researchers are particularly interested in their biological activities, which could lead to new therapeutic agents.
  • Functional Groups: The presence of various functional groups, including the oxa and diaza groups, allows for diverse reactivity patterns that could be exploited in synthetic chemistry.
  • Cyclopropylmethyl Substituent: The cyclopropylmethyl group in the structure adds a unique level of sterics and electronics, which can influence the compound's reactivity and interaction with biological macromolecules.
  • Analytical Techniques: The study of such complex compounds usually requires advanced analytical techniques such as NMR, MS, and X-ray crystallography, shedding light on their structure and properties.

As we dive deeper into the exploration of compounds like this one, we not only unravel the potential applications in various fields, including medicinal chemistry but also enhance our understanding of complex molecular systems, challenging our creativity and problem-solving skills as scientists.

Synonyms
22-(Cyclopropylmethyl)-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5,7,9,15,17,19(25)-heptaene-2,16-diol
SCHEMBL5173517
BDBM86662
CHEBI:91903
LSM-1839
NSC_3034754
CAS_111555-53-4
L000430
BRD-A82656074-003-01-2
Q27163702
(1S,2S,13R,21S)-22-(Cyclopropylmethyl)-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5,7,9,15,17,19(25)-heptaene-2,16-diol