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Diclofenac hydrate

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Identification
Molecular formula
C14H11Cl2NO2
CAS number
15307-79-6
IUPAC name
2,2-dichloro-N-[1-(hydroxymethyl)-2-(4-nitrophenyl)-2-oxo-ethyl]acetamide
State
State

At room temperature, diclofenac hydrate generally exists in a solid state. It is often encountered in the form of fine crystals or powder.

Melting point (Celsius)
283.00
Melting point (Kelvin)
556.15
Boiling point (Celsius)
560.70
Boiling point (Kelvin)
833.90
General information
Molecular weight
294.15g/mol
Molar mass
294.1530g/mol
Density
1.5300g/cm3
Appearence

The compound typically presents as an off-white to pale yellow crystalline powder. It is sensitive to light and should be stored in a light-free environment to prevent degradation.

Comment on solubility

Solubility of 2,2-dichloro-N-[1-(hydroxymethyl)-2-(4-nitrophenyl)-2-oxo-ethyl]acetamide

The solubility of 2,2-dichloro-N-[1-(hydroxymethyl)-2-(4-nitrophenyl)-2-oxo-ethyl]acetamide, a complex organic compound, can be influenced by several factors. Understanding its solubility characteristics is essential for applications in various chemical processes. Here are some key points to consider:

  • Polarity: The presence of hydroxymethyl and nitrophenyl groups indicates that this compound may exhibit moderate to high polarity, potentially increasing its solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability to form hydrogen bonds due to the hydroxymethyl group can further enhance solubility in polar solvents.
  • Solvent Compatibility: While it may be soluble in water, its solubility in organic solvents, such as ethanol or acetone, depends on hydrophobic interactions from the aromatic and chloro-substituents.
  • Temperature Effect: As with many organic compounds, increasing the temperature may enhance solubility, allowing more effective dissolution.

In general, the solubility profile of 2,2-dichloro-N-[1-(hydroxymethyl)-2-(4-nitrophenyl)-2-oxo-ethyl]acetamide suggests that while it may demonstrate favorable solubility in polar environments, its complete dissolution behavior would need to be experimentally verified to account for all intermolecular interactions.

Interesting facts

Interesting Facts About 2,2-Dichloro-N-[1-(hydroxymethyl)-2-(4-nitrophenyl)-2-oxo-ethyl]acetamide

This complex compound, often referred to in scientific discussions as a type of substituted acetamide, showcases the intricate nature of organic chemistry. Here are some intriguing aspects to consider:

  • Structure Complexity: The compound features multiple functional groups, including dichloro and nitrophenyl moieties, contributing to its diverse chemical behavior. The presence of both chloro and nitro groups indicates potential for varied reactivity and biological activity.
  • Biological Significance: Compounds like this one are often studied for their potential pharmaceutical applications. The modifications in the side chains suggest that the compound may exhibit interesting interactions with biological targets.
  • Nitrophenyl Group: The presence of the 4-nitrophenyl group is noteworthy, as nitrophenyl derivatives are widely used in various chemical reactions, including reduction processes and as building blocks in dye synthesis.
  • Hydroxymethyl Functionality: The hydroxymethyl group not only serves as a point for further functionalization but also may enhance the compound's solubility in biological systems, thereby influencing its pharmacokinetic properties.
  • Research Applications: Because of its unique structure, this compound can be a valuable subject for research in areas such as medicinal chemistry, where modifications to acetamide chains might lead to the development of new therapeutic agents.

In essence, 2,2-dichloro-N-[1-(hydroxymethyl)-2-(4-nitrophenyl)-2-oxo-ethyl]acetamide serves as a fascinating example of how specific chemical modifications can lead to a wide range of biological and chemical properties, making it a point of interest among chemists and researchers alike.

Synonyms
Dehydrochloramphenicol
26367-75-9
DH-CAP
(+-)-2,2-Dichloro-N-(alpha-(hydroxymethyl)-p-nitrophenacyl)acetamide
DTXSID20949225
Acetamide, 2,2-dichloro-N-(1-(hydroxymethyl)-2-(4-nitrophenyl)-2-oxoethyl)-
Acetamide, 2,2-dichloro-N-(alpha-(hydroxymethyl)-p-nitrophenacyl)-, (+-)-
2,2-Dichloro-N-[3-hydroxy-1-(4-nitrophenyl)-1-oxopropan-2-yl]ethanimidic acid