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Chloramphenicol

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Identification
Molecular formula
C11H12Cl2N2O5
CAS number
56-75-7
IUPAC name
2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
State
State

At room temperature, Chloramphenicol is generally found in a solid state, notably as a crystalline powder. It maintains its solid form unless exposed to melting conditions over its melting point.

Melting point (Celsius)
150.00
Melting point (Kelvin)
423.15
Boiling point (Celsius)
283.00
Boiling point (Kelvin)
556.15
General information
Molecular weight
323.13g/mol
Molar mass
323.1340g/mol
Density
1.7000g/cm3
Appearence

Chloramphenicol is a white to greyish-white crystalline substance. It can also be off-white. The appearance is influenced by the presence of polymorphs, but typically it appears as fine, white crystals or crystalline powder.

Comment on solubility

Solubility of 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide

The solubility of the compound 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide (C11H12Cl2N2O5) can be affected by several factors.

Factors Influencing Solubility

  • Polarity: The presence of multiple functional groups, such as hydroxyl (-OH) and nitro (-NO2), can enhance polarity, which may lead to increased solubility in polar solvents like water.
  • Hydrogen Bonding: Capable of forming hydrogen bonds, the -OH groups can significantly enhance solubility in polar solvents through interactions with water molecules.
  • Chlorination: The presence of chlorine atoms can impact the overall solubility, as halogens generally introduce nonpolar characteristics, potentially reducing solubility in nonpolar solvents.

General Solubility Trends

In general, we can summarize the solubility expectations as follows:

  • **Soluble** in organic solvents with some degree of polarity.
  • **Slightly soluble** in water, due to the balancing effects of polar and nonpolar groups.
  • May exhibit variable solubility depending on temperature and pH.

Overall, while C11H12Cl2N2O5 may have moderate solubility, further empirical studies are recommended for precise quantification and to explore its behavior in various solvents.

Interesting facts

Interesting Facts about 2,2-Dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide

This intriguing compound is a member of a larger class of chemicals known for their versatile applications and structural complexity. Here are some fascinating insights into its characteristics and significance:

  • Pharmaceutical Potential: Compounds like this one often have potential applications in pharmaceuticals, particularly as drug intermediates. Their unique structure can interact with biological targets, leading to therapeutic effects.
  • Functional Groups: The presence of various functional groups, including dichloro, hydroxymethyl, and nitrophenyl, contributes to the compound’s reactivity and properties. Each group can impart specific characteristics, making it suitable for diverse chemical reactions.
  • Structure Activity Relationship (SAR): Studying the SAR of this compound can provide insights into how structural modifications can lead to better efficacy or reduced toxicity in drug design. Scientists often analyze these relationships to hone in on optimal candidates for further study.
  • Research Applications: This compound, with its unique blend of functional groups, may be of interest in fields such as biochemistry and medicinal chemistry. Researchers might explore its potential as a synthesis precursor or assess its biological activity.

In conclusion, the world of 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide is rich with potential for discovery. As researchers continue to unravel the complexities of this compound, who knows what innovative applications might arise?

Synonyms
579-51-1
2,2-dichloro-N-[1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
Dextromycetin
Tyfomycine
Cloramfen
2,2-DICHLORO-N-(1,3-DIHYDROXY-1-(4-NITROPHENYL)PROPAN-2-YL)ACETAMIDE
Ak-chlor
2,2-Dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
Gloveticol
Mycochlorin
Ocuphenicol
Sintomicetin
Chlorocin
Halcetin
Levocin
Levoplast
Levosin
Levovetin
Myclocin
Soluthor
(-)-chloramphenicol
Acetamide,2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-
Ophthocort (Salt/Mix)
126787-77-7
SMR000058224
Chloromyxin (Salt/Mix)
Elase-Chloromycetin (Salt/Mix)
Prestwick_51
NCGC00094620-01
MFCD00007360
Maybridge1_004345
Cambridge id 5158421
CBDivE_006107
MLS000028814
MLS001074349
MLS001183729
MLS001331694
SCHEMBL537158
CHEMBL414400
D-(-)-threo-1-(p-Nitrophenyl)-2-(dichloroacetylamino)-1,3-propanediol
D-(-)-threo-N-Dichloroacetyl-1-p-nitrophenyl-2-amino-1,3-propanediol
CHEBI:94390
HMS553N13
DTXSID70859002
WIIZWVCIJKGZOK-UHFFFAOYSA-N
HMS2235A18
HMS3259N13
HMS3370M09
HMS3655E19
2787-09-9
Acetamide, 2,2-dichloro-N-(.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenethyl)-, D-(-)-threo-
Acetamide, 2,2-dichloro-N-[.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenethyl]-, D-threo-(-)-
D-(-)-threo-2,2-Dichloro-N-(.beta.-hydroxy-.alpha.-(hydroxymethyl)-p-nitrophenyl-ethyl)acetamide
HAA38489
SYB70602
CCG-52635
NSC163311
STK177237
AKOS000521670
AKOS016874635
AB02994
NC00653
NSC-163311
SB48404
NCGC00094620-02
NCGC00094620-03
NS00126318
EN300-50870
SR-01000641855-1
Q27166237
2,2-dichloro-N-[1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl] acetamide
2,2-dichloro-N-[2-hydroxy-1(hydroxyl-methyl)-2(4-nitrophenyl)ethyl]acetamide