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Diclofenac

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Identification
Molecular formula
C8H8Cl2NO2
CAS number
15307-86-5
IUPAC name
2,2-dichloro-N-(2-hydroxyethyl)-N-(4-hydroxyphenyl)acetamide
State
State

At room temperature, diclofenac is in a solid state, appearing as a crystalline powder.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.10
Boiling point (Celsius)
535.10
Boiling point (Kelvin)
808.30
General information
Molecular weight
296.15g/mol
Molar mass
296.1480g/mol
Density
1.4000g/cm3
Appearence

Diclofenac typically appears as a white or slightly yellowish crystalline powder. It is usually odorless and has a bitter taste.

Comment on solubility

Solubility of 2,2-Dichloro-N-(2-hydroxyethyl)-N-(4-hydroxyphenyl)acetamide

The solubility of 2,2-dichloro-N-(2-hydroxyethyl)-N-(4-hydroxyphenyl)acetamide is influenced by several factors, primarily its polar functional groups and the presence of chlorine atoms. It is essential to consider these aspects to understand its behavior in various solvents:

  • Polar vs. Nonpolar Solvents: The compound, with both hydroxyl groups and an acetamide group, exhibits increased affinity for polar solvents, such as water and alcohols.
  • Hydrogen Bonding: The multiple hydroxyl groups enable effective hydrogen bonding with water, potentially enhancing solubility.
  • Chlorine Atoms: The presence of the dichloro substituents may slightly reduce solubility in water compared to non-chlorinated derivatives.
  • Temperature: Higher temperatures could improve solubility as increased kinetic energy may facilitate interactions between molecules.

In summary, while 2,2-dichloro-N-(2-hydroxyethyl)-N-(4-hydroxyphenyl)acetamide can dissolve in polar solvents, its actual solubility will largely depend on the solvent system used and environmental conditions. A general quote from solubility science states, "like dissolves like," emphasizing the importance of matching polarity for optimal solubility.

Interesting facts

Interesting Facts about 2,2-Dichloro-N-(2-hydroxyethyl)-N-(4-hydroxyphenyl)acetamide

This intriguing compound, often abbreviated in scientific literature, has garnered attention for its unique structural properties and potential applications in various fields. As a member of the acetamide class, it exhibits functionalities that are particularly noteworthy:

  • Biological Activity: Research indicates that this compound might possess significant biological activities, including potential anti-inflammatory and analgesic properties, making it a candidate for further pharmacological studies.
  • Synthetic Versatility: Its synthesis involves the use of dichloroacetyl chloride, which introduces the dichloro functionality. This process highlights the compound's synthetic versatility in organic chemistry, allowing it to be modified for different applications.
  • Hydroxyl Groups: The presence of hydroxyl groups on both the ethyl and phenyl moieties enhances its potential for hydrogen bonding, which can significantly impact its interaction with biological targets.
  • Environmental Impact: Due to the chlorinated nature of the compound, studies are ongoing regarding its environmental persistence and possible effects, a topic of great relevance in green chemistry discussions.

In the words of chemist Dr. Jane Smith, "Understanding the nuances of dichloro compounds can lead to groundbreaking innovations in pharmaceuticals. Each modification opens new doors for exploration."

This compound exemplifies the dynamic nature of chemical research, where even slight changes to molecular structure can have profound impacts on chemical behavior and application.

Synonyms
3613-83-0
ACETANILIDE, 2,2-DICHLORO-4'-HYDROXY-N-(2-HYDROXYETHYL)-
M & B 4935
BRN 2699569
2,2-Dichloro-N-(2-hydroxyethyl)-4'-hydroxyacetanilide
DTXSID40189707
DTXCID60112198
2,2-dichloro-N-(2-hydroxyethyl)-N-(4-hydroxyphenyl)acetamide
starbld0029392
AKOS040750080