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2,2-Difluoroacetic acid

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Identification
Molecular formula
C2HF2O2
CAS number
381-73-7
IUPAC name
2,2-difluoroacetic acid
State
State

At room temperature, 2,2-difluoroacetic acid is a liquid.

Melting point (Celsius)
-17.00
Melting point (Kelvin)
256.15
Boiling point (Celsius)
132.00
Boiling point (Kelvin)
405.15
General information
Molecular weight
112.04g/mol
Molar mass
112.0370g/mol
Density
1.3481g/cm3
Appearence

2,2-Difluoroacetic acid is typically a colorless liquid with a pungent odor characteristic of carboxylic acids. It is often handled in a well-ventilated area due to its strong, acrid scent.

Comment on solubility

Solubility of 2,2-Difluoroacetic Acid

2,2-Difluoroacetic acid, with the chemical formula C2H2F2O2, exhibits notable properties regarding its solubility in various solvents. As a carboxylic acid, it demonstrates good solubility in polar solvents, particularly water, due to the ability of its carboxyl group to form hydrogen bonds. Here are some key points to consider:

  • Water Solubility: 2,2-Difluoroacetic acid is highly soluble in water. This high solubility is attributed to its polar nature and the presence of electronegative fluorine atoms, which enhance its interaction with water molecules.
  • Organic Solvents: It is also soluble in many organic solvents, including ethanol and methanol, allowing for a range of applications in different chemical reactions.
  • Solvent Pairing: The acid's solubility can be influenced by the choice of solvent; hence, it is advisable to consider solvent polarity when preparing solutions of this compound.

In conclusion, 2,2-difluoroacetic acid's solubility characteristics make it a versatile compound for various laboratory and industrial processes. Its ability to dissolve in both polar and non-polar solvents expands its utility in chemical synthesis.

Interesting facts

Interesting Facts about 2,2-Difluoroacetic Acid

2,2-Difluoroacetic acid is a fascinating compound due to its unique properties and applications in various fields. Here are some notable points:

  • Fluorinated Compound: This compound contains two fluorine atoms attached to the acetic acid molecule, enhancing its reactivity and stability.
  • Reagent in Organic Synthesis: 2,2-Difluoroacetic acid is often used as a reagent in organic synthesis, particularly in the production of fluorinated pharmaceuticals, agrochemicals, and other specialty chemicals.
  • Biological Activity: It exhibits interesting biological properties, making it a subject of research in medicinal chemistry. Its fluorinated structure can influence biological activity and interactions with biological targets.
  • Thermodynamic Stability: The presence of fluorine atoms contributes to the compound's thermodynamic stability, leading to lower reactivity compared to its non-fluorinated counterparts. This stability is beneficial in reaction conditions where other acids might decompose.
  • Environmental Considerations: Fluorinated compounds are often scrutinized for their environmental impact. Understanding 2,2-difluoroacetic acid helps in assessing the risks and benefits associated with its use.

In summary, 2,2-difluoroacetic acid is more than just a simple carboxylic acid; its fluorinated nature gives it distinct properties that are valuable in both scientific research and industrial applications. As the field of chemistry continues to evolve, this compound represents the creative potential of fluorinated compounds in developing innovative solutions.

Synonyms
DIFLUOROACETIC ACID
381-73-7
2,2-Difluoroacetic acid
Acetic acid, difluoro-
Difluoressigsaeure
1,1-difluoroacetic acid
UNII-ZQK1C95K3N
EINECS 206-839-0
ZQK1C95K3N
Acetic acid, 2,2-difluoro-
BRN 1098588
CHEBI:23716
AI3-28548
DTXSID2059932
EC 206-839-0
4-02-00-00455 (Beilstein Handbook Reference)
C2H2F2O2
difluoracetic acid
Acetic acid, difluoro- (6CI,7CI,8CI,9CI); 2,2-Difluoroacetic acid; Difluoroacetic acid
Difluoro-acetic acid
MFCD00004220
Difluoroacetic acid, 98%
CHEMBL453969
DTXCID5039430
UMVBMCIAQFZUKB-UHFFFAOYSA-N
FD2068
STK260852
AKOS000118821
FD53770
BP-10757
PS-18111
DB-049243
CS-0015390
D1423
NS00003534
EN300-19507
Q15126139
Z104474070
206-839-0