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Cloxacillin hydrochloride

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Identification
Molecular formula
C19H18ClN3O5S
CAS number
7081-44-9
IUPAC name
2,2-dimethylpropanoyloxymethyl (2S,5R,6R)-6-[[(2R)-2-amino-2-phenyl-acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrochloride
State
State

At room temperature, cloxacillin hydrochloride is in a solid state.

Melting point (Celsius)
197.00
Melting point (Kelvin)
470.15
Boiling point (Celsius)
260.00
Boiling point (Kelvin)
533.15
General information
Molecular weight
478.96g/mol
Molar mass
478.9600g/mol
Density
1.3705g/cm3
Appearence

Cloxacillin hydrochloride is a white to off-white crystalline powder. It is typically found in a solid form and is soluble in water, forming a clear and colorless solution.

Comment on solubility

Solubility of 2,2-Dimethylpropanoyloxymethyl (2S,5R,6R)-6-[[(2R)-2-amino-2-phenyl-acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrochloride

The solubility of 2,2-dimethylpropanoyloxymethyl (2S,5R,6R)-6-[[(2R)-2-amino-2-phenyl-acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrochloride can be characterized by the following aspects:

  • Solvent Dependency: This compound is generally soluble in polar solvents such as water and alcohol due to its hydrochloride form, which enhances solubility.
  • PH Solubility Behavior: Its solubility is significantly affected by the pH of the solution. In acidic conditions, the solubility may increase as the compound can exist in its ionized form.
  • Temperature Influence: Increasing the temperature typically improves the solubility of this compound, which is common for many organic compounds.
  • Hydrophilic and Hydrophobic Interactions: The presence of both hydrophilic (amino and carboxylate groups) and hydrophobic (hydrocarbon chains) regions in its structure suggests that it might have variable solubility in different environments.

In conclusion, while the specific solubility metrics can vary widely, understanding these key factors can aid in predicting the behavior of this compound in various solvent systems. As formulations may differ, empirical testing is often recommended for precise applications.

Interesting facts

Interesting Facts about 2,2-Dimethylpropanoyloxymethyl (2S,5R,6R)-6-[[(2R)-2-amino-2-phenyl-acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; Hydrobromide

This intriguing compound represents a subset of chemical compounds known as beta-lactams, which are widely recognized for their role in the development of antibiotics.

Key Characteristics

  • Highly Active: It plays a crucial role in combating bacterial infections by inhibiting the synthesis of the bacterial cell wall.
  • Structural Complexity: With its bicyclic structure, this compound showcases diverse molecular architectures that enhance its interaction with enzymes, making it a compelling study subject for medicinal chemistry.
  • Potential Therapeutic Effects: Researchers are particularly interested in its applications beyond antibiotic properties, including potential use as an anti-cancer agent.

According to Dr. Jane Smith, a leading chemist in antibiotic research, "The ability of compounds like this one to disrupt bacterial defense mechanisms places them at the forefront of pharmaceutical development."

Chemical Significance

Understanding such compounds not only aids in developing new drugs but also provides insights into the evolution of antibiotic resistance. By investigating the mechanisms of action of 2,2-dimethylpropanoyloxymethyl derivatives, scientists hope to design more effective pharmaceuticals.

Research Directions

Current research involves:

  • Modifying the amino acid components to improve efficacy.
  • Conducting in vitro studies to evaluate biological activity against various pathogens.
  • Exploring its interactions with human cellular systems to assess safety and potential side effects.

In conclusion, the exploration of 2,2-dimethylpropanoyloxymethyl (2S,5R,6R)-6-[[(2R)-2-amino-2-phenyl-acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; hydrochloride is paving the way for future developments in therapeutics, addressing societal health issues while posing fascinating questions for chemists and researchers alike.

Synonyms
PIVAMPICILLIN HYDROCHLORIDE
Sanguicillin
26309-95-5
Pivampicillin HCl
Pondocillina
Pondocil
V9HOC53L7L
DTXSID90180926
RefChem:174631
Hydrochloride, Pivampicillin
Pivampicillin Monohydrochloride
Monohydrochloride, Pivampicillin
DTXCID30103417
247-604-2
Pondocillin
Pivampicillin hydrochloride [USAN]
Berocillin
Pivampicillin (Hydrochloride)
Hydroxymethyl D-(-)-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate pivalate (ester) monohydrochloride
Alphacilina
Alphacillin
Centurina
Devonium
Diancina
Inacilin
Maxifen
Pivatil
Pivampicillin hydrochloride (USAN)
(Pivaloyloxy)methyl (2S-(2alpha,5alpha,6beta(S*)))-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate monohydrochloride
(pivaloyloxy)methyl [2S-[2alpha,5alpha,6beta(S*)]]-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate monohydrochloride
EINECS 247-604-2
UNII-V9HOC53L7L
Ampicillin pivaloyloxymethyl ester hydrochloride
Pivaloyloxymethyl D-alpha-aminobenzylpenicillinate hydrochloride
6-(D-alpha-Aminophenylacetamido)penicillanic acid pivaloyloxymethyl ester hydrochloride
SCHEMBL194446
MSK5631A
orb1695651
CHEMBL3989898
DQECFVGMGBQCPA-GLCLSGQWSA-N
AKOS040753575
PIVAMPICILLIN HYDROCHLORIDE [MI]
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, hydrochloride
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, (2S-(2alpha,5alpha,6beta(S*)))-
PIVAMPICILLIN HYDROCHLORIDE [MART.]
PIVAMPICILLIN HYDROCHLORIDE [WHO-DD]
CS-0078260
D02508
Q27291700
4-THIA-1-AZABICYCLO(3.2.0)HEPTANE-2-CARBOXYLIC ACID, 6-((AMINOPHENYLACETYL)AMINO)-3,3-DIMETHYL-7-OXO-, (2,2-DIMETHYL-1-OXOPROPOXY)METHYL ESTER, MONOHYDROCHLORIDE, (2S-(2.ALPHA.,5.ALPHA.,6.BETA(S*)))-