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N,N-Dimethyl-4-(trichloroacetyl)benzenesulfonamide

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Identification
Molecular formula
C10H11Cl3NO2S
CAS number
101-20-2
IUPAC name
2,2,2-trichloro-N-[4-(dimethylsulfamoyl)phenyl]acetamide
State
State

At room temperature, the compound is typically found in a solid state. It exhibits significant stability, which is characteristic of many chlorinated organic compounds.

Melting point (Celsius)
147.00
Melting point (Kelvin)
420.15
Boiling point (Celsius)
285.00
Boiling point (Kelvin)
558.15
General information
Molecular weight
296.64g/mol
Molar mass
296.6420g/mol
Density
1.6200g/cm3
Appearence

The compound primarily appears as a white crystalline solid, which is typical for many organic compounds of this type. The crystals are formed due to the highly ordered stacking of its molecules, often making it powdery in texture when handled.

Comment on solubility

Solubility of 2,2,2-trichloro-N-[4-(dimethylsulfamoyl)phenyl]acetamide

The solubility of 2,2,2-trichloro-N-[4-(dimethylsulfamoyl)phenyl]acetamide can be quite intriguing due to the compound's unique structure and functional groups. Its solubility characteristics are influenced by several key factors:

  • Polarity: The presence of chlorine atoms and the sulfonamide group contribute to the compound's polarity, which can result in a higher solubility in polar solvents.
  • Hydrogen Bonding: The amide functionality allows for potential hydrogen bonding with solvents, enhancing solubility in polar environments.
  • Solvent Type: This compound may show better solubility in organic solvents such as dimethyl sulfoxide (DMSO) or acetone, while its solubility in water might be limited because of its larger, hydrophobic aromatic moiety.

Many researchers have observed that "the solubility of complex molecules often requires careful consideration of the solvent system." Therefore, when handling this compound, one should:

  1. Conduct solubility tests in different solvents to identify optimal conditions.
  2. Take note of temperature effects, as solubility can change significantly with temperature variations.
  3. Use techniques such as sonication to enhance dissolution in challenging solvents.

In summary, while 2,2,2-trichloro-N-[4-(dimethylsulfamoyl)phenyl]acetamide may have moderate solubility due to its polar features, understanding the interplay of its components is crucial for effective application in various chemical processes.

Interesting facts

Interesting Facts about 2,2,2-Trichloro-N-[4-(dimethylsulfamoyl)phenyl]acetamide

This compound, known as a derivative of acetaminophen, plays a significant role in the field of medicinal chemistry. Here are some fascinating insights:

  • Medicinal Applications: It has been studied for its potential use in anti-inflammatory and analgesic properties, making it a candidate for pain relief research.
  • Unique Structure: The presence of three chlorine atoms contributes to its enhanced reactivity, which is crucial for its biological activity.
  • Sulfamoyl Group: The dimethylsulfamoyl moiety impacts the compound's pharmacological properties, potentially improving solubility and bioavailability.
  • Research Relevance: Due to its complex structure, it serves as a valuable model for developing new therapies targeting various diseases.
  • Safety Considerations: As with many halogenated compounds, careful attention is needed for handling and disposal due to potential toxicity.

In the realm of chemical research, compounds like 2,2,2-trichloro-N-[4-(dimethylsulfamoyl)phenyl]acetamide highlight the intricate interplay between structure and function, paving the way for innovative drug development. As we delve deeper into its mechanism of action, we may uncover novel approaches for combating pain and inflammation.

Remember, in the world of chemistry, every compound has the potential to reveal new therapeutic pathways, making it an exciting field of study!

Synonyms
23280-37-7
ACETANILIDE, 2,2,2-TRICHLORO-4'-(DIMETHYLSULFAMOYL)-
NSC 137239
2,2,2-Trichloro-4'-(dimethylsulfamoyl)acetanilide
DTXSID00177847
N(sup 4)-Tricloroacetil-N(sup 1)-dimetil-benzensulfonamida [Romanian]
N(sup 4)-Tricloroacetil-N(sup 1)-dimetil-benzensulfonamida
RefChem:315694
DTXCID60100338
LQC6WQ3SJT
NSC-137239
NSC137239
UNII-LQC6WQ3SJT
DS-006239
2,2,2-Trichloro-N-[4-[(dimethylamino)sulfonyl]phenyl]acetamide
Acetamide, 2,2,2-trichloro-N-[4-[(dimethylamino)sulfonyl]phenyl]-
ACETAMIDE,2,2,2-TRICHLORO-N-[4-[(DIMETHYLAMINO)SULFONYL]PHENYL]-