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2,2,2-Trifluoroethanol

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Identification
Molecular formula
C2H3F3O
CAS number
75-89-8
IUPAC name
2,2,2-trifluoro-1-methoxy-ethanol
State
State

At room temperature, 2,2,2-Trifluoroethanol is a liquid, characterized by its ability to dissolve both polar and non-polar compounds.

Melting point (Celsius)
-43.50
Melting point (Kelvin)
229.65
Boiling point (Celsius)
74.80
Boiling point (Kelvin)
347.95
General information
Molecular weight
100.04g/mol
Molar mass
100.0420g/mol
Density
1.3485g/cm3
Appearence

2,2,2-Trifluoroethanol is a colorless liquid that is miscible with water and most organic solvents. It has a slightly pungent odor and is often used as a solvent in organic synthesis due to its unique solvation properties.

Comment on solubility

Solubility of 2,2,2-Trifluoro-1-methoxy-ethanol

2,2,2-Trifluoro-1-methoxy-ethanol, with the chemical formula C4H7F3O2, exhibits interesting solubility characteristics due to its unique structure. Here are some key points to consider:

  • Polarity: The presence of the methoxy group (-OCH3) and the trifluorinated carbon makes this compound quite polar, enhancing its ability to interact with polar solvents.
  • Water Solubility: It is generally soluble in water, making it useful in applications where aqueous media are involved.
  • Organic Solvents: The compound is also soluble in a range of organic solvents, including alcohols and ethers, due to its moderate hydrophilicity.
  • Solubility Patterns: Solubility can vary significantly based on temperature and pH, with increased solubility often observed as temperature rises.

In summary, 2,2,2-trifluoro-1-methoxy-ethanol exemplifies a compound whose solubility is largely influenced by its polar functional groups, making it versatile for various chemical applications. Its interaction with different solvents opens avenues for innovative uses in both synthetic and analytical chemistry.

Interesting facts

Interesting Facts about 2,2,2-Trifluoro-1-methoxy-ethanol

2,2,2-Trifluoro-1-methoxy-ethanol, often referred to as TFM, is a fascinating compound that showcases the intriguing interplay between organic chemistry and fluorine chemistry. Here are some engaging facts about this unique substance:

  • Fluorinated Ethers: This compound belongs to a class of chemicals known as fluorinated ethers, which are characterized by the presence of fluorine atoms. The three fluorine atoms contribute to its remarkable properties, making it an excellent candidate for various applications in pharmaceuticals and agrochemicals.
  • Polar Solvent: TFM exhibits polar characteristics due to the presence of the hydroxyl (-OH) group. This polarity makes it an effective solvent for polar compounds, allowing chemists to conduct reactions and extractions that require a suitable medium.
  • Industrial Uses: The unique chemical properties of 2,2,2-trifluoro-1-methoxy-ethanol position it as a useful intermediate in the synthesis of other complex molecules, particularly in the development of fluorinated pharmaceuticals.
  • Biocompatibility: The fluorinated nature of this compound often enhances the metabolic stability of drugs developed from it, leading to longer-lasting effects in biological systems.
  • Environmental Considerations: With increasing awareness about environmental impact, researchers examine the degradation patterns of TFM to ensure it adheres to green chemistry principles, striving for sustainable methodologies in its production and application.
  • Research Frontiers: Ongoing research delves into the unique interactions that TFM may have in biological systems, particularly regarding its pharmacokinetics and potential therapeutic roles.

In summary, 2,2,2-trifluoro-1-methoxy-ethanol is more than just another compound; it is a testament to how innovative chemistry can blend functionality with environmental responsibility. As scientists continue to unlock its potential, TFM may pave the way for new and improved materials in various fields.

Synonyms
Trifluoroacetaldehyde methyl hemiacetal
431-46-9
2,2,2-Trifluoro-1-methoxyethanol
Fluoral methyl hemiacetal
1-Methoxy-2,2,2-trifluoroethanol
Ethanol, 2,2,2-trifluoro-1-methoxy-
EINECS 207-072-4
MFCD00013572
BRN 1737758
Trifluoroacetaldehyde methyl hemiacetal, tech.
Trifluoroacetaldehyde methyl hemiacetal, tech grade
GWTBCUWZAVMAQV-UHFFFAOYSA-
ETHANOL, 1-METHOXY-2,2,2-TRIFLUORO-
DTXSID30883383
Trifluoroacetaldehyde Methyl Hemiacetal (contains ca. 10% Methanol)
TRIFLUOROACETALDEHYDEMETHYLHEMIACETAL
Trifluoroacetaldehyde methyl hemiacetal (tech.)
2,2,2-trifluoro-1-methoxyethan-1-ol
CF3CH(OCH3)OH
CF3CH(OH)OCH3
SCHEMBL501205
DTXCID201022918
2,2,2-trifluoro-1-methoxy-ethanol
trifluoroacetaldehyde methylhemiacetal
AKOS005206787
Perfluoroacetaldehyde Methyl Hemiacetal
FT84725
SB83891
trifluoroacetaldehyde methyl hemi-acetal
MS-20238
SY048821
DB-051039
NS00043401
T3247
EN300-179568
F72236
Trifluoroacetaldehyde methyl hemiacetal, AldrichCPR
207-072-4