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2,2,2-Trifluoroacetophenone

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Identification
Molecular formula
C8H5F3O
CAS number
434-45-7
IUPAC name
2,2,2-trifluoro-1-phenyl-ethanone
State
State

At room temperature, 2,2,2-Trifluoroacetophenone is a liquid. It has a relatively low melting point just below room temperature, which makes it remain in the liquid state under standard conditions.

Melting point (Celsius)
-4.00
Melting point (Kelvin)
269.15
Boiling point (Celsius)
129.00
Boiling point (Kelvin)
402.15
General information
Molecular weight
174.13g/mol
Molar mass
174.1320g/mol
Density
1.2510g/cm3
Appearence

2,2,2-Trifluoroacetophenone is a colorless liquid. It is often described to have a pleasant aroma, resembling that of benzaldehyde or almond, which is due to its phenyl group.

Comment on solubility

Solubility of 2,2,2-Trifluoro-1-phenyl-ethanone

2,2,2-Trifluoro-1-phenyl-ethanone, with the chemical formula C9H7F3O, exhibits interesting solubility properties that stem from its unique functional groups and molecular structure.

This compound is generally considered to be:

  • Moderately soluble in organic solvents such as ethanol and acetone.
  • Less soluble in water due to its hydrophobic aromatic component and fluorinated structure.
  • Partially soluble in non-polar solvents, as the presence of fluorine can influence the solvent-solute interactions.

It is important to note that the solubility can be affected by temperature and pressure, and the addition of certain co-solvents can enhance solubility in polar solvents. 

As a general rule, fluorinated compounds tend to demonstrate lower solubility in water compared to their non-fluorinated analogues, primarily due to:

  • Increased molecular polarity
  • Stronger carbon-fluorine bonds

For practical applications, understanding the solubility of 2,2,2-trifluoro-1-phenyl-ethanone can be crucial when determining its behavior in various chemical processes or formulations.

Interesting facts

Interesting Facts about 2,2,2-Trifluoro-1-phenyl-ethanone

2,2,2-Trifluoro-1-phenyl-ethanone, commonly known in the chemical community for its unique properties and applications, is a noteworthy compound that merges the realms of organic chemistry and pharmaceuticals. Here are some intriguing aspects:

  • Fluorination Effects: The presence of trifluoromethyl groups can significantly influence the reactivity and stability of organic compounds. This characteristic often leads to enhanced bioactivity and lipophilicity in pharmaceutical applications.
  • Versatile Building Block: This compound serves as an essential intermediate in the synthesis of various biologically active molecules, making it a valuable resource for medicinal chemists.
  • Light-Sensitive Properties: The **phenyl** group introduces a degree of photostability, which is crucial when dealing with compounds that require exposure to light in their applications.
  • Environmentally Relevant: Fluorinated compounds like 2,2,2-trifluoro-1-phenyl-ethanone are of growing interest for their potential use in green chemistry, where minimizing environmental impact is a priority.
  • Research Applications: This compound is often used as a model system in experiments studying the properties of fluorinated organic materials, thereby advancing our understanding of carbon-fluorine chemistry.

In addition to these properties, the unique electronic and structural features of 2,2,2-trifluoro-1-phenyl-ethanone open doors to inquiries into new synthetic routes and enhanced methods of functionalization. Scientists regularly explore its potential in creating innovative solutions in pharmaceuticals and agrochemicals.

As we delve deeper into the study of this compound, we may uncover new implications and applications that could revolutionize various fields, prompting chemists to consider 2,2,2-trifluoro-1-phenyl-ethanone as not just a compound, but a key player in future scientific advancements.

Synonyms
2,2,2-TRIFLUOROACETOPHENONE
434-45-7
Trifluoroacetophenone
2,2,2-Trifluoro-1-phenylethanone
alpha,alpha,alpha-Trifluoroacetophenone
Trifluoromethyl phenyl ketone
2,2,2-trifluoro-1-phenylethan-1-one
Ethanone, 2,2,2-trifluoro-1-phenyl-
Phenyl trifluoromethyl ketone
2,2,2-Trifluoro-1-phenyl-ethanone
Acetophenone, 2,2,2-trifluoro-
1,1,1-Trifluoroacetophenone
(Trifluoroacetyl)benzene
NSC 42752
6T7L1UPY09
phenyltrifluoromethylketone
EINECS 207-103-1
NSC-42752
CHEMBL293277
DTXSID6059992
.alpha.,.alpha.,.alpha.-Trifluoroacetophenone
.omega.,.omega.,.omega.-Trifluoroacetophenone
2,2,2-TRIFLUORO-1-PHENYL-1-ETHANONE
MFCD00000420
TRIFLUOROACETYLBENZENE
UNII-6T7L1UPY09
trifluoromethylphenylketone
1,1-Trifluoroacetophenone
2,2-Trifluoroacetophenone
trifluoromethylphenyl ketone
SCHEMBL33083
Acetophenone,2,2-trifluoro-
2,2,2Trifluoro1phenylethanone
Acetophenone, 2,2,2trifluoro
2,2-Trifluoro-1-phenylethanone
DTXCID9040261
Ethanone, 2,2,2trifluoro1phenyl
Ethanone,2,2-trifluoro-1-phenyl-
NSC42752
2,2,2-Trifluoroacetophenone, 98%
2,2,2-Trifluoroacetophenone, 99%
alpha,alpha,alphaTrifluoroacetophenone
BDBM50163190
STL444353
.alpha.,.alpha.-Trifluoroacetophenone
Acetophenone, 2,2,2trifluoro (8CI)
AKOS005254512
omega,omega,omega-Trifluoroacetophenone
Acetophenone, 2,2,2-trifluoro-(8CI)
acetophenone, alpha-alpha-alpha-trifluoro-
DB-391882
CS-0031430
NS00043356
T0848
EN300-51325
F16442
Q27265490
F0001-1195
Z649458352
207-103-1
234-45-7