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TFNA (Trifluoroacetamide)

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Identification
Molecular formula
C15H9F3N2O3
CAS number
.
IUPAC name
2,2,2-trifluoro-N-(7-nitro-9H-fluoren-2-yl)acetamide
State
State

At room temperature, this compound is a solid. It is typically encountered in a crystalline form and is stable under normal conditions.

Melting point (Celsius)
166.50
Melting point (Kelvin)
439.65
Boiling point (Celsius)
313.20
Boiling point (Kelvin)
586.35
General information
Molecular weight
308.24g/mol
Molar mass
308.2410g/mol
Density
1.5120g/cm3
Appearence

2,2,2-Trifluoro-N-(7-nitro-9H-fluoren-2-yl)acetamide appears as a crystalline solid. The compound's color ranges from pale yellow to bright yellow, depending on purity and conditions. The crystals may exhibit some fluorescence under ultraviolet light due to the presence of the nitro and fluorenyl groups.

Comment on solubility

Solubility of 2,2,2-trifluoro-N-(7-nitro-9H-fluoren-2-yl)acetamide

The solubility of 2,2,2-trifluoro-N-(7-nitro-9H-fluoren-2-yl)acetamide in various solvents can provide important insights into its chemical behavior. This compound, featuring both polar and non-polar groups, demonstrates unique solubility characteristics:

  • Polar Solvents: Generally, compounds with polar functional groups are more soluble in polar solvents such as water, methanol, or ethanol. Given the presence of the acetamide group, 2,2,2-trifluoro-N-(7-nitro-9H-fluoren-2-yl)acetamide could exhibit significant solubility in these solvent systems.
  • Non-Polar Solvents: The presence of multiple fluorine atoms contributes to the hydrophobic character of this compound, suggesting that it might also dissolve in non-polar solvents like hexane or toluene, albeit to a lesser extent.
  • pH Dependence: The solubility may vary with pH, especially considering the potential for the amide functional group to engage in protonation or deprotonation processes.

In summary, the solubility of 2,2,2-trifluoro-N-(7-nitro-9H-fluoren-2-yl)acetamide is likely to depend on the balance between its polar and non-polar characteristics, thus affecting its interactions with different solvents. Studying this solubility behavior can provide essential information for its practical applications in various chemical contexts.

Interesting facts

Interesting Facts about 2,2,2-Trifluoro-N-(7-nitro-9H-fluoren-2-yl)acetamide

2,2,2-Trifluoro-N-(7-nitro-9H-fluoren-2-yl)acetamide is a compound that presents fascinating characteristics and applications, particularly in the realms of medicinal and synthetic chemistry. Here are some engaging insights into this intriguing compound:

  • Unique Structure: This compound features a trifluoromethyl group, which dramatically affects its chemical properties, often enhancing its ability to interact with biological systems.
  • Medicinal Chemistry: Due to the presence of both the nitro and acetamide functional groups, it shows potential as a lead compound in the development of pharmaceuticals. Compounds with such moieties can be vital in the design of novel drugs.
  • Fluorine's Influence: The trifluoro group is known for modifying a compound's lipophilicity and metabolic stability, making it a focus of research in drug design. As a highlight, fluorinated compounds often exhibit improved pharmacokinetics.
  • Research Applications: The unique properties of 2,2,2-trifluoro-N-(7-nitro-9H-fluoren-2-yl)acetamide also make it a useful tool in the fields of materials science and agrochemicals.
  • Potential Toxicity: As with many nitro compounds, toxicity is an important consideration. Understanding the environmental and biological impact of this compound is crucial, guiding scientists in its safe application.

In conclusion, 2,2,2-trifluoro-N-(7-nitro-9H-fluoren-2-yl)acetamide is not just a compound of theoretical interest but is at the intersection of innovative research avenues. Its unique structure and multifaceted applications continue to inspire scientists and chemists alike.

Synonyms
2926-70-7
2,2,2-trifluoro-N-(7-nitro-9H-fluoren-2-yl)acetamide
ACETAMIDE, N-(7-NITROFLUOREN-2-YL)-2,2,2-TRIFLUORO-
2-Trifluoroacetamido-7-nitrofluorene
SP8UKF5PW8
N-(7-Nitrofluoren-2-yl)-2,2,2-trifluoroacetamide
MLS002638249
NSC-12285
Acetamide, 2,2,2-trifluoro-N-(7-nitro-9H-fluoren-2-yl)-
NSC 12285
BRN 2821332
NSC12285
UNII-SP8UKF5PW8
CHEMBL354075
Acetamide,2,2,2-trifluoro-N-(7-nitro-9H-fluoren-2-yl)-
DTXSID90183513
KQTBJIDQYNJEKV-UHFFFAOYSA-N
HMS3089D24
7-NITRO-2-(2,2,2-TRIFLUOROACETAMIDO)-FLU ORENE, 98%
AKOS017345232
SMR001547738
DS-009516
7-NITRO-2-(2,2,2-TRIFLUOROACETAMIDO)-FLUORENE