Skip to main content

2,2,2-trifluoro-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

ADVERTISEMENT
Identification
Molecular formula
C19H20F3NO6
CAS number
132514-11-9
IUPAC name
2,2,2-trifluoro-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
State
State

At room temperature, this compound is typically in a solid state.

Melting point (Celsius)
146.50
Melting point (Kelvin)
419.70
Boiling point (Celsius)
502.50
Boiling point (Kelvin)
775.70
General information
Molecular weight
467.43g/mol
Molar mass
467.4250g/mol
Density
1.3200g/cm3
Appearence

2,2,2-Trifluoro-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide typically appears as a white or off-white crystalline solid. It is often used in chemical synthesis and research applications.

Comment on solubility

Solubility of 2,2,2-trifluoro-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

The solubility of a compound plays a crucial role in its application and utility in various fields, including pharmaceuticals and materials science. In the case of 2,2,2-trifluoro-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide, its unique structure suggests specific solubility traits. Here are some key points to consider:

  • Polarity: The presence of trifluoromethyl groups and methoxy substituents typically increases polarity, which may enhance solubility in polar solvents.
  • Interaction with Solvents: The strong electronegative nature of the fluorine atoms can create favorable interactions with solvents, leading to potential solubility in mixed polar-apolar solvent systems.
  • Solid State: If the compound is solid at room temperature, its crystalline structure will significantly influence solvent interactions and solubility.
  • Temperature Dependency: As with many compounds, solubility may increase with temperature due to enhanced molecular motion.

Moreover, it is essential to note that while general trends provide some insight into solubility behavior, experimental solubility testing is critical for accurate assessments. This aids in determining practical usability in different solvents, ensuring desired efficacy in its applications.

As a quote from Robert H. Peters aptly puts it, "Solubility is the key to reactivity and versatility in chemistry." This statement resonates particularly with compounds like 2,2,2-trifluoro-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide, where understanding solubility opens up new possibilities for research and development.

Interesting facts

Interesting Facts about 2,2,2-Trifluoro-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

This intriguing compound showcases a unique combination of functional groups that contribute to its diverse properties and potential applications. Below are some noteworthy points:

  • Fluorinated Compound: The presence of the trifluoro group enhances the compound's stability, lipophilicity, and its ability to interact with biological targets.
  • Mechanistic Interest: The structure features a complex polycyclic framework, which is notable for its potential to serve as a scaffold in medicinal chemistry, particularly in drug design.
  • Natural Product Derivative: The structural motif derived from the benzo[a]heptalene core suggests biological relevance, possibly hinting at activities in natural product chemistry or bioactivity.
  • Stereochemistry: The specific stereoconfiguration at the (7S) position underscores its importance in biological activity, as stereochemistry plays a crucial role in the interaction of compounds with biological receptors.

Furthermore, this compound opens the door to explorations in:

  • Pharmaceutical Development: With its unique combination of fluorination and a complex organic framework, it has the potential to act as a lead in designing new therapeutic agents.
  • Material Science: Its properties may lend themselves to advancements in materials with specific electronic or optical characteristics.

The study of such compounds not only enriches our understanding of chemistry but also paves the way for innovations in various fields, from drug discovery to material science. As a chemistry student, exploring this compound prompts one to think critically about the implications of structure on reactivity and biological interaction.

Synonyms
26195-65-3
COLCHICINE, 17,17,17-TRIFLUORO-
NSC 305987
N-Deacetyl-N-(trifluoroacetyl)colchicine
BRN 3021687
DTXSID90180825
RefChem:334303
DTXCID30103316
N-Trifluoroacetyl Deacetylcolchicine
2,2,2-trifluoro-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
17,17,17-Trifluorocolchicine
NSC305987
CHEMBL83406
N-Trifluoroacetyl-N-deacetylcolchicine
NSC-305987
DB-231168
Acetamide,2,2-trifluoro-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-