Skip to main content

2,2,5,5-Tetrakis(trifluoromethyl)-1H-imidazol-4-amine

ADVERTISEMENT
Identification
Molecular formula
C7H2F12N3
CAS number
119689-47-9
IUPAC name
2,2,5,5-tetrakis(trifluoromethyl)-1H-imidazol-4-amine
State
State

At room temperature, 2,2,5,5-tetrakis(trifluoromethyl)-1H-imidazol-4-amine is a solid.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
260.00
Boiling point (Kelvin)
533.15
General information
Molecular weight
351.08g/mol
Molar mass
351.0770g/mol
Density
1.7500g/cm3
Appearence

The compound is typically a white crystalline solid under standard conditions.

Comment on solubility

Solubility of 2,2,5,5-Tetrakis(trifluoromethyl)-1H-imidazol-4-amine

When discussing the solubility of 2,2,5,5-tetrakis(trifluoromethyl)-1H-imidazol-4-amine, it is important to consider several factors that affect its behavior in various solvents. Here are some key points:

  • Polarity: The presence of multiple trifluoromethyl groups significantly increases polarity, making the compound potentially soluble in polar solvents like water and alcohols.
  • Hydrogen bonding: The amine functional group may enable hydrogen bonding, which can further enhance solubility in solvent systems capable of accepting or donating hydrogen bonds.
  • Solvent interactions: Compatibility with non-polar solvents tends to be limited due to the overall structure's polar character; thus, substances like toluene or hexane may not dissolve it effectively.

As a general observation, the solubility behavior of this compound can be summarized as follows:

  1. Likely soluble in polar aprotic solvents (e.g., dimethyl sulfoxide, acetonitrile).
  2. Possibly less soluble in aliphatic hydrocarbons.

In conclusion, while the solubility of 2,2,5,5-tetrakis(trifluoromethyl)-1H-imidazol-4-amine is influenced by the nature of the solvents used, its unique molecular structure suggests that it may display promising solubility properties in polar environments.

Interesting facts

Interesting Facts about 2,2,5,5-Tetrakis(trifluoromethyl)-1H-imidazol-4-amine

2,2,5,5-Tetrakis(trifluoromethyl)-1H-imidazol-4-amine is a fascinating compound well-known for its unique structural features and applications in various scientific fields. Here are some intriguing aspects of this compound:

  • Fluorinated Functional Group: This compound has multiple trifluoromethyl groups that significantly enhance its chemical reactivity and stability. The introduction of CF3 groups can modify the polarity and biological activity of the compound, leading to various applications in pharmaceuticals.
  • Imidazole Core: The imidazole ring is a five-membered aromatic system that is widely recognized in biological systems, particularly in the structure of amino acids, such as histidine. This ring structure contributes to the compound's ability to engage in hydrogen bonding, making it useful for different catalytic and biological processes.
  • Potential Therapeutic Applications: Researchers have been exploring compounds containing imidazole derivatives due to their potential as organic compounds with diverse biological activities, including antiviral and anticancer properties.
  • Research Interest: The unique properties of this compound make it a subject of study in medicinal chemistry and materials science. It can be a key precursor or building block in synthesizing more complex molecules.
  • Environmental Significance: Investigating the behavior of trifluoromethylated compounds could shed light on environmental chemistry, particularly regarding persistence and bioaccumulation, due to the stability imparted by fluorine atoms.

The versatility and distinctive features of 2,2,5,5-tetrakis(trifluoromethyl)-1H-imidazol-4-amine make it an intriguing compound for study. As scientists continue to examine its properties and applications, we can anticipate exciting developments in related fields.

Synonyms
MIDAFLUR
23757-42-8
Midaflurum
EXP 338
EXP-338
4-Amino-2,2,5,5-tetrakis(trifluoromethyl)-3-imidazoline
840CTL676L
1H-Imidazol-4-amine, 2,5-dihydro-2,2,5,5-tetrakis(trifluoromethyl)-
DTXSID50178425
3-IMIDAZOLINE, 4-AMINO-2,2,5,5-TETRAKIS(TRIFLUOROMETHYL)-
2,5-Dihydro-2,2,5,5-tetrakis(trifluoromethyl)-1H-imidazol-4-amine
RefChem:925880
DTXCID80100916
2,2,5,5-tetrakis(trifluoromethyl)-1H-imidazol-4-amine
Midaflur [USAN:INN]
Midaflurum [INN-Latin]
UNII-840CTL676L
5-Amino-2,2,4,4-tetrakis(trifluoromethyl)imidazolidine
MIDAFLUR [USAN]
Midaflur (USAN/INN)
MIDAFLUR [INN]
SCHEMBL113656
CHEMBL2104707
KYWMWUUMCDZISK-UHFFFAOYSA-N
NS00123044
D05027
Q27269463
1,4,6,9-Tetraoxa-5.lambda.^4-telluraspiro[4.4]nonane, 2,2,3,3,7,7,8,8-octakis(trifluoromethyl)-
7233-63-8