Skip to main content

2,2,5,5-tetrakis(trifluoromethyl)-1H-pyrrol-3-amine

ADVERTISEMENT
Identification
Molecular formula
C8H4F12N
CAS number
141670-69-7
IUPAC name
2,2,5,5-tetrakis(trifluoromethyl)-1H-pyrrol-3-amine
State
State

At room temperature, 2,2,5,5-tetrakis(trifluoromethyl)-1H-pyrrol-3-amine exists as a solid due to its relatively high melting point compared to typical ambient temperatures.

Melting point (Celsius)
139.00
Melting point (Kelvin)
412.15
Boiling point (Celsius)
263.00
Boiling point (Kelvin)
536.15
General information
Molecular weight
322.11g/mol
Molar mass
322.0750g/mol
Density
2.0600g/cm3
Appearence

2,2,5,5-tetrakis(trifluoromethyl)-1H-pyrrol-3-amine is typically a white to off-white crystalline solid. The crystalline nature is attributed to the robust intermolecular interactions among the molecules.

Comment on solubility

Solubility of 2,2,5,5-tetrakis(trifluoromethyl)-1H-pyrrol-3-amine

The solubility of 2,2,5,5-tetrakis(trifluoromethyl)-1H-pyrrol-3-amine can be quite complex due to its unique chemical structure. Here are several key points regarding its solubility:

  • Polarity: The presence of multiple trifluoromethyl groups contributes to the overall polarity of the compound, which can influence its solubility in various solvents.
  • Solvent Compatibility: This compound is likely to be more soluble in polar aprotic solvents, such as DMSO and DMF, rather than in nonpolar solvents due to its polar functional groups.
  • Temperature Dependence: Like many organic compounds, its solubility may increase with temperature, making it important to consider the conditions during dissolution.
  • Hydrogen Bonding: The presence of the amine group may allow for hydrogen bonding interactions in suitable solvents, potentially increasing solubility.

Overall, while specific solubility data may not always be readily available for such specialized compounds, understanding the influence of molecular structure on solubility is crucial. As a general observation, 2,2,5,5-tetrakis(trifluoromethyl)-1H-pyrrol-3-amine is expected to exhibit moderate to good solubility in polar solvents, with varying degrees based on concentration, temperature, and the solvent's characteristics.

Interesting facts

Interesting Facts about 2,2,5,5-tetrakis(trifluoromethyl)-1H-pyrrol-3-amine

2,2,5,5-tetrakis(trifluoromethyl)-1H-pyrrol-3-amine is a fascinating compound that represents the intricate interplay between organic chemistry and fluorinated compounds. Below are some intriguing aspects of this compound:

  • Fluorination: The presence of multiple trifluoromethyl groups (-CF3) profoundly affects both the physical and chemical properties of this compound. These groups are known for their electronegativity and hydrophobic nature, making the compound highly resistant to polar solvents.
  • Biological Activity: Compounds with fluorinated moieties often exhibit enhanced biological activity. They can be crucial in pharmaceutical research and development, frequently leading to novel therapeutic agents with improved efficacy.
  • Applications in Material Science: The unique characteristics of this compound make it a candidate for various applications in material science, particularly in the development of coatings and polymers that require enhanced durability and chemical resistance.
  • Environmental Impact: While fluorinated compounds are valuable in many industrial applications, they can also raise environmental concerns due to their persistence in the ecosystem. Understanding the fate and transport of such compounds is a critical area of ongoing research.
  • Synthesis Challenges: The synthesis of highly fluorinated organic compounds like this one can pose significant challenges. Scientists often employ specialized techniques to control the introduction of fluorine atoms, reflecting the advanced methodologies required in modern organic synthesis.

In summary, 2,2,5,5-tetrakis(trifluoromethyl)-1H-pyrrol-3-amine is not just a mere compound but a testament to the advancements in organic chemistry. Its unique features and potential applications illustrate the evolving landscape of chemical research.