Trihexadecanoin | Solubility of Things

Identification

Molecular formula

C₅₁H₉₈O₆

CAS number

3333-18-6

IUPAC name

2,3-di(hexadecanoyloxy)propyl hexadecanoate

State

At room temperature, trihexadecanoin is in a solid state. This is because it contains relatively long chains of hexadecanoyl (palmitoyl) groups, resulting in a higher melting point. The solid form can melt at body temperature, therefore it is sometimes used in topical applications without causing an oily sensation.

Melting point (Celsius)

44.00

Melting point (Kelvin)

317.15

Boiling point (Celsius)

474.00

Boiling point (Kelvin)

747.15

General information

Molecular weight

806.36g/mol

Molar mass

806.4720g/mol

Density

0.9477g/cm³

Appearence

Trihexadecanoin is typically a waxy solid at room temperature. It is often seen as a white or off-white substance, with a smooth texture. Its solid form is due to the long aliphatic chains of the fatty acids involved. This compound can also appear slightly yellowish if impurities are present.

Comment on solubility

Solubility of 2,3-di(hexadecanoyloxy)propyl hexadecanoate

The solubility of 2,3-di(hexadecanoyloxy)propyl hexadecanoate can be characterized by several key factors:

Hydrophobic Nature: Being a long-chain fatty acid derivative, 2,3-di(hexadecanoyloxy)propyl hexadecanoate is primarily hydrophobic. This means it tends to have low solubility in water.
Solvent Interactions: It is more soluble in organic solvents, particularly non-polar solvents such as hexane, chloroform, and ethyl acetate.
Temperature Dependency: The solubility may increase with temperature when dissolved in organic solvents, as it enhances molecular motion and interactions.
Influence of Structure: The substantial hydrophobic hexadecanoyloxy chains contribute to its overall solubility behavior by increasing the molecule's size and causing limited interaction with polar solvents.

Ultimately, it is essential to consider these factors when determining the solubility of 2,3-di(hexadecanoyloxy)propyl hexadecanoate in various environments. Overall, the general trend indicates a limited solubility in polar solvents, while showing favorable solubility in non-polar solvents.

Interesting facts

Interesting Facts about 2,3-di(hexadecanoyloxy)propyl hexadecanoate

2,3-di(hexadecanoyloxy)propyl hexadecanoate is a fascinating compound with a rich structure and a variety of applications. Here are some engaging points to consider:

Complex Structure: This compound features a glycerol backbone with two hexadecanoyloxy groups and one hexadecanoate group. Such a structure allows for unique interactions and properties.
Uses in Biomedicine: Due to its amphiphilic nature, it can be utilized in drug delivery systems and nanocarriers. The long hydrophobic hexadecanoyl chains contribute to its ability to encapsulate hydrophobic drugs.
Surface Activity: Compounds like this often exhibit surfactant properties, which can lower surface tension and enhance the stability of emulsions in various formulations.
Biocompatibility: Given its fatty acid derivation, this compound is generally regarded as biocompatible, making it a suitable candidate for medical applications in drug formulation and tissue engineering.
Research Significance: Research studies have shown that derivatives of fatty acid esters can play an essential role in formulating lipid-based nanoparticles, which are pivotal in modern drug delivery strategies.

In summary, 2,3-di(hexadecanoyloxy)propyl hexadecanoate represents a remarkable intersection of chemistry and application, showcasing how complex organic compounds can lead to innovative solutions in healthcare and beyond.

Synonyms

TRIPALMITIN

555-44-2

Glycerol tripalmitate

Glyceryl tripalmitate

Tripalmitoylglycerol

Palmitic triglyceride

Tripalmitate

Dynasan 116

Triglyceryl palmitate

Barolub

Spezialfett 116

Glyceryl trihexadecanoate

Barolub LCD

Palmitin, tri-

Hexadecanoic acid, 1,2,3-propanetriyl ester

Speziafett 116

Palmitic acid triglycerin ester

Glycerin tripalmitate

Dynosan 114

tripalmitina

tripalmitine

CCRIS 6992

1,2,3-Propanetriol trihexadecanoate

EINECS 209-098-1

UNII-D133ZRF50U

BRN 1811188

D133ZRF50U

trihexadecanoylglycerol

DTXSID8046169

CHEBI:77393

AI3-31759

TG(16:0/16:0/16:0)

1,2,3-propanetriyl trihexadecanoate

propane-1,2,3-triyl trihexadecanoate

1,2,3-trihexadecanoylglycerol

DTXCID6026169

4-02-00-01176 (Beilstein Handbook Reference)

Tripalmitoyl glycerol

tripalmitinum

tripalmitylglycerol

glycero-tripalmitate

209-098-1

Propane-1,2,3-triyl tripalmitate

Tripalmitin [INN]

1,2,3-trihexadecanoyl-glycerol

1,2,3-trihexadecanoyl-sn-glycerol

Hexadecanoic acid, 1,1',1''-(1,2,3-propanetriyl) ester

MFCD00008995

NCGC00160468-01

1,3-bis(hexadecanoyloxy)propan-2-yl hexadecanoate

2,3-di(hexadecanoyloxy)propyl hexadecanoate

Triglyceride PPP

Glyceryltripalmitate

TRIPALMITIN [MI]

Glyceryl trihexadecanoic acid

SCHEMBL24941

Tripalmitin or 1,2,3-propanetriyl trihexadecanoate

Glycerol tripalmitate,97.5%

Glyceryl tripalmitate, >=85%

Glyceryl tripalmitate, >=99%

CHEMBL2002154

HY-W013061R

Tox21_111834

LMGL03010001

AKOS015899780

CS-W013777

FG11067

HY-W013061

2,3-Bis(palmitoyloxy)propyl palmitate #

NCGC00160468-02

Tripalmitin, NIST(R) SRM(R) 1595

AS-60925

CAS-555-44-2

FG179174

SY048302

G0091

G0213

NS00014187

T3096

Propane-1,2,3-triyl tripalmitate (Standard)

D90728

SR-01000944841

Q7843226

SR-01000944841-1

TG 16:0/16:0/16:0