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Dihydrobenzofuran-2-ylmethanamine

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Identification
Molecular formula
C9H11NO
CAS number
114772-54-2
IUPAC name
2,3-dihydrobenzofuran-2-ylmethanamine
State
State

At room temperature, dihydrobenzofuran-2-ylmethanamine is typically found in a liquid state. Its exact state can vary slightly with changes in environmental conditions such as temperature and pressure due to its relatively low melting point.

Melting point (Celsius)
41.00
Melting point (Kelvin)
314.15
Boiling point (Celsius)
238.50
Boiling point (Kelvin)
511.65
General information
Molecular weight
149.20g/mol
Molar mass
149.1960g/mol
Density
1.0680g/cm3
Appearence

Dihydrobenzofuran-2-ylmethanamine typically appears as a colorless or pale yellow transparent liquid, depending on its purity and exact sample conditions. Its appearance can be described as somewhat viscous, similar to other organic amines.

Comment on solubility

Solubility of 2,3-Dihydrobenzofuran-2-ylmethanamine

The solubility of 2,3-dihydrobenzofuran-2-ylmethanamine can be intriguing due to its unique chemical structure. This compound, often cited for its medicinal relevance, features functional groups that can interact with solvents in interesting ways:

  • Polar Nature: The presence of the amine group (-NH2) suggests that 2,3-dihydrobenzofuran-2-ylmethanamine may exhibit moderate solubility in polar solvents such as water.
  • Non-Polar Characteristics: The benzofuran moiety contributes non-polar aspects, which may lead to better solubility in organic solvents such as ethanol and methanol.
  • Hydrogen Bonding: The ability of the amine group to form hydrogen bonds can enhance solubility in aqueous environments, making it potentially soluble in physiological conditions.

It is important to note that solubility can also be influenced by factors such as:

  1. Temperature: Higher temperatures usually increase solubility for many compounds.
  2. pH Levels: The degree of protonation of the amine group may vary with pH, affecting solubility.
  3. Presence of Salts: Ionic strength in a solution can also alter solubility patterns.

In summary, the solubility of 2,3-dihydrobenzofuran-2-ylmethanamine is a multifaceted topic that reflects the balance between its polar and non-polar characteristics. Experimentation with different solvents can yield valuable insights into its solubility behavior.

Interesting facts

Interesting Facts about 2,3-Dihydrobenzofuran-2-ylmethanamine

2,3-Dihydrobenzofuran-2-ylmethanamine is a fascinating compound that captures the interest of chemists and researchers alike. Its unique structure and potential applications make it a subject of study in various fields, especially in medicinal chemistry. Here are some key points to consider:

  • Structural Composition: This compound features a benzofuran ring, which is known for its aromatic properties and stability. The presence of a methanamine group enhances its reactivity, making it valuable in synthetic organic chemistry.
  • Pharmaceutical Potential: Compounds similar to 2,3-dihydrobenzofuran derivatives have been investigated for their biological activity. Research suggests that derivatives of this structure may possess valuable pharmacological properties, including anti-inflammatory and analgesic effects.
  • Role in Syntheses: This compound can serve as an intermediate in the synthesis of other complex molecules. Chemists often explore its potential to create new substances with targeted properties for drug development.
  • Synthesis Methods: Various methods exist for synthesizing 2,3-dihydrobenzofuran-2-ylmethanamine, including cyclization reactions, which are essential tools in organic synthesis. These methods can refine processes for producing pharmaceuticals more efficiently.
  • Environmental Considerations: As with many organic compounds, it's vital to consider the environmental impact of their synthesis and use. Green chemistry principles encourage finding sustainable methods that reduce hazardous waste and energy consumption.

As researchers continue to discover new applications and properties associated with 2,3-dihydrobenzofuran-2-ylmethanamine, the compound remains an exciting subject in the ongoing quest for innovative solutions in chemistry and medicine.

Synonyms
(2,3-Dihydrobenzofuran-2-yl)methanamine
21214-11-9
2,3-dihydro-1-benzofuran-2-ylmethanamine
C-(2,3-Dihydro-benzofuran-2-yl)-methylamine
1-(2,3-dihydro-1-benzofuran-2-yl)methanamine
MFCD03724810
(2,3-dihydro-1-benzofuran-2-yl)methanamine
3-dihydrobenzofuran-2-yl)MethanaMine
2,3-dihydrobenzo[d]furan-2-ylmethylamine
2-aminomethyl-2,3-dihydrobenzofuran
2,3-dihydrobenzofuran-2-ylmethanamine
SCHEMBL718265
SCHEMBL7380988
SCHEMBL29841223
DTXSID40274884
ASPSZCAHOMXPBE-UHFFFAOYSA-N
HMS1681H19
SBB013722
STK503417
19997-54-7 (HCl salt)
AKOS000169118
AKOS016042122
SB35375
NCGC00343055-01
BS-13452
DA-08243
ST4128472
EN300-35758
AB01334944-02
F8881-5515
Z291234246