Skip to main content

Berberine chloride

ADVERTISEMENT
Identification
Molecular formula
C20H18NO4Cl
CAS number
633-65-8
IUPAC name
2,3-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride
State
State

At room temperature, berberine chloride is a solid. It is typically found in its crystalline form.

Melting point (Celsius)
204.00
Melting point (Kelvin)
477.00
Boiling point (Celsius)
540.00
Boiling point (Kelvin)
813.00
General information
Molecular weight
336.36g/mol
Molar mass
336.3610g/mol
Density
1.3803g/cm3
Appearence

Berberine chloride appears as a yellow crystalline solid. It is known for its bright yellow color, which is highly visible and distinct.

Comment on solubility

Solubility of 2,3-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride

The solubility of 2,3-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride can be influenced by several factors. Understanding its solubility profile is crucial for various applications, especially in pharmaceutical formulations. Here are some key points to consider:

  • Polarity: The presence of methoxy groups suggests some polar character, which may enhance its solubility in polar solvents.
  • Ionization: Being a quaternary ammonium compound, the chloride can be dissociated in aqueous solutions, potentially increasing solubility in water.
  • Solvent Compatibility: The compound may show varying solubility across different solvents. High polar solvents like water or methanol could solvate ions effectively.
  • Temperature Dependency: Solubility may increase with temperature, making hot solvent applications more effective.
  • pH Sensitivity: Changes in pH can affect the ionization state of the compound, impacting solubility; thus, it’s essential to evaluate the solubility at different pH levels.

In summary, the solubility of 2,3-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride is likely to show considerable variability based on the solvent environment and conditions. Careful experimentation is necessary to establish comprehensive solubility data for practical applications.

Interesting facts

Interesting Facts about 2,3-Dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium; Chloride

This fascinating compound, known for its unique structural features, falls under the category of phenanthridine derivatives, which are known for their diverse applications in medicinal chemistry. Here are some intriguing aspects of this compound:

  • Biological Activity: Compounds related to phenanthridines exhibit a range of biological activities, including anti-cancer properties. Researchers are continually investigating the potential of such structures in developing novel anti-tumor agents.
  • Fluorescence: Due to their conjugated systems, many phenanthridine derivatives display significant fluorescence. This property makes them valuable in a variety of applications, from fluorescent dyes to biological imaging.
  • Electron Deficiency: The specific structural configuration of 2,3-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium contributes to its electron deficiency, which can enhance its reactivity with other compounds in synthetic chemistry.
  • Ion Pairing: As a chloride salt, this compound can engage in ion-pairing interactions, which is crucial for its solubility and bioavailability in various formulations.
  • Research Potential: The unique arrangement of the benzodioxole and phenanthridine moieties opens up numerous pathways for chemical modification, providing ample opportunities for researchers to explore its derivatives and their applications.

As Dr. Jane Doe once stated, "The true beauty of chemistry lies not just in the compounds we know, but in the endless possibilities that emerge once we begin to explore their structures." This compound embodies that beauty, representing a blend of complexity and potential that intrigues both chemists and students alike.

In summary, 2,3-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium; chloride is not merely a chemical entity; it is a potential key to unlocking new avenues in chemical science and medicinal chemistry.

Synonyms
Nitidine chloride
13063-04-2
Nitidine, chloride
XO8WQL69T8
NSC-146397
(1,3)-BENZODIOXOLO(5,6-c)PHENANTHRIDINIUM, 2,3-DIMETHOXY-12-METHYL-, CHLORIDE
UNII-XO8WQL69T8
2,3-Dimethoxy-12-methyl-(1,3)-benzodioxolo(5,6-c)phenanthridinium chloride
2,3-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride
1,3)BENZODIOXOLO(5,6-C)PHENANTHRIDINIUM, 2,3-DIMETHOXY-12-METHYL-, CHLORIDE (1:1)
2,3-dimethoxy-12-methyl-(1,3)benzodioxolo(5,6-c)phenanthridin-12-ium;chloride
Nitidine, chloride (8CI)
2,3-Dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-ium chloride
Nitidine (chloride)
NSC146397
13063-04-2 (CHLORIDE)
[1,3]Benzodioxolo[5,6-c]phenanthridinium, 2,3-dimethoxy-12-methyl-, chloride (1:1)
C21H18ClNO4
Nitidine-Chloride
[1,3]Benzodioxolo[5,6-c]phenanthridinium, 2,3-dimethoxy-12-methyl-, chloride (1:1); Nitidine, chloride (6CI,7CI,8CI); [1,3]Benzodioxolo[5,6-c]phenanthridinium, 2,3-dimethoxy-12-methyl-, chloride (9CI); NSC 146397
CHEMBL8443
SCHEMBL420918
Nitidine (chloride) (Standard)
HY-N0498R
DTXSID50926842
HY-N0498
MFCD01659688
AKOS016003480
CCG-268448
FN65676
2,3-Dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]-benzo[1,2-c]phenanthridin-12-ium chloride
AS-73875
DB-050205
CS-0009022
WLN: T G6 D6 C665 EK SO UO THJ E1 IO1 JO1 &G
[1,6-c]phenanthridinium, 2,3-dimethoxy-12-methyl-, chloride
2,3-Dimethoxy-12-methyl-9H-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium chloride
16,17-DIMETHOXY-21-METHYL-5,7-DIOXA-21-AZAPENTACYCLO[11.8.0.0(2),(1)?.0?,?.0(1)?,(1)?]HENICOSA-1(13),2(10),3,8,11,14(19),15,17,20-NONAEN-21-IUM CHLORIDE
2,3-Dimethoxy-12-methyl-[1,3]dioxolo[4\',5\':4,5]benzo[1,2-c]phenanthridin-12-ium chloride