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Tetrandrine

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Identification
Molecular formula
C38H42N2O6
CAS number
518-34-3
IUPAC name
2,3,10,11-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline
State
State
Tetrandrine is typically a solid at room temperature. It is often encountered in a powdered form, making it easier to handle for chemical and pharmacological applications.
Melting point (Celsius)
214.40
Melting point (Kelvin)
487.60
Boiling point (Celsius)
769.58
Boiling point (Kelvin)
1 042.73
General information
Molecular weight
622.76g/mol
Molar mass
622.6800g/mol
Density
1.2681g/cm3
Appearence

Tetrandrine is a crystalline alkaloid that typically appears as a white or off-white powder. It may also have a faint beige tint depending on the purity. It is known for its glossy crystalline structure when viewed under a microscope.

Comment on solubility

Solubility of 2,3,10,11-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline

The solubility of 2,3,10,11-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline is influenced by several key factors associated with its molecular structure. Generally, compounds like this isoquinoline derivative can exhibit varied solubility profiles depending on the environment in which they are placed.

Key Factors Influencing Solubility:

  • Polarity: The presence of multiple methoxy (-OCH3) groups increases its polarity, which may enhance solubility in polar solvents such as water.
  • Molecular Size: The larger and more complex structure may hinder solubility in less polar solvents due to steric effects.
  • Hydrogen Bonding: Hydrogen-bonding capabilities can also play a crucial role in solubility by interacting with solvent molecules.

It is important to note that the solubility can vary significantly depending on temperature and pressure conditions. In summary, while this compound is likely to show moderate solubility in polar solvents due to its methoxy substituents, further empirical testing would be needed to define its solubility profile accurately.

Interesting facts

Interesting Facts about 2,3,10,11-Tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline

The compound 2,3,10,11-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline is a fascinating member of the isoquinoline family, which is known for its broad range of biological activities. Here are some intriguing aspects of this compound:

  • Structural Complexity: The intricate structure comprising multiple methoxy groups and a unique bicyclic ring system allows for varied interactions within biological systems, making it an interesting subject for medicinal chemistry.
  • Biological Significance: Isoquinoline derivatives, including this compound, have been found to exhibit a variety of pharmacological properties, such as antitumor, antimicrobial, and analgesic activities.
  • Natural Occurrence: Compounds of this type can often be isolated from certain plant species, contributing to their relevance in traditional medicine as well as modern drug development.
  • Synthetic Challenges: The synthesis of such complex molecules often requires innovative approaches and techniques in organic chemistry, allowing chemists to explore new methodologies and reaction mechanisms.
  • Chemical Versatility: Due to its numerous functional groups, this compound is a versatile precursor for further chemical modifications, paving the way for new derivatives with enhanced properties.

As research continues to unveil the potential of such compounds, the exploration of their mechanisms of action could lead to new therapeutic strategies in treating various diseases. With its rich structural complexity and biological relevance, 2,3,10,11-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline undoubtedly captures the attention of scientists and students alike!

Synonyms
beta-Norcoralydine
d-Xylopinine
(+)-Xylopinine
2,3,10,11-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline
R-(+)-Xylopinine
523-02-4
MLS002638117
13407-95-9
NSC10105
6872-27-1
(+-)-Xylopinine
2,10,11-Tetramethoxyberbine
(+-)-Norcoralydine
Berbine,3,10,11-tetramethoxy-
l-Xylopinine
NSC 17067
6H-DIBENZO(a,g)QUINOLIZINE, 5,8,13,13a-TETRAHYDRO-2,3,10,11-TETRAMETHOXY-, (R)-
NSC 241040
dl-Xylopinine
6H-Dibenzo[a, 5,8,13,13a-tetrahydro-2,3,10,11-tetramethoxy-
6H-DIBENZO(a,g)QUINOLIZINE, 5,8,13,13a-TETRAHYDRO-2,3,10,11-TETRAMETHOXY-, (S)-
Berbine, 2,3,10,11-tetramethoxy-, (+-)-
4216-86-8
13aalpha-Berbine, 2,3,10,11-tetramethoxy-
13a-alpha-Berbine, 2,3,10,11-tetramethoxy-
6H-Dibenzo(a,g)quinolizine, 5,8,13,13a-tetrahydro-2,3,10,11-tetramethoxy-, (+-)-
Oprea1_143577
SCHEMBL910941
CHEMBL2357282
DTXSID50988420
2,3,10,11-Tetramethoxyberbine
NSC-10105
NSC118074
NSC241040
STK366271
AKOS005443430
NSC-118074
NSC-241040
SMR001547608
BERBINE,3-10,11-TETRAMETHOXY-, HYDRATE
AE-508/21137006
2,3,10,11-Tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline
2,3,10,11-Tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline