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Colchicine

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Identification
Molecular formula
C22H25NO6
CAS number
64-86-8
IUPAC name
(2,3,4-trimethoxy-13-methyl-6,7,11,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-17-yl) hydrogen sulfate
State
State

At room temperature, colchicine is typically found as a solid. It is used predominantly in research and has significant medicinal applications owing to its biological activities.

Melting point (Celsius)
150.50
Melting point (Kelvin)
423.60
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
399.44g/mol
Molar mass
399.4360g/mol
Density
1.6000g/cm3
Appearence

Colchicine appears as a white to pale yellow crystalline powder. It is typically odorless and is known for its high sensitivity to light.

Comment on solubility

Solubility of (2,3,4-trimethoxy-13-methyl-6,7,11,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-17-yl) hydrogen sulfate

The solubility of this compound can be intriguing due to its complex structure. Understanding solubility involves considering various factors such as the compound's molecular composition, the presence of functional groups, and the solvent used.

Key Factors Influencing Solubility:

  • Polarity: As a sulfate ester, the presence of the hydrogen sulfate group contributes to the polarity of the molecule, enhancing its solubility in polar solvents such as water.
  • Functional Groups: The methoxy groups (-OCH3) may induce some degree of solubility in organic solvents, making it more compatible with less polar solvents as well.
  • Hydrophobic Characteristics: The alkane-like structure of the cyclopenta[a]phenanthrene moiety suggests potential hydrophobic interactions, which could affect solubility in various media.
  • Temperature: Increasing temperature may improve solubility in some solvents, allowing the compound's higher energy state to disrupt intermolecular forces.

In summary, the solubility of (2,3,4-trimethoxy-13-methyl-6,7,11,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-17-yl) hydrogen sulfate is expected to be influenced by both its polar sulfate and hydrophobic hydrocarbon components. Understanding these interactions is critical for predicting its behavior in different environments.

Interesting facts

Interesting Facts about (2,3,4-trimethoxy-13-methyl-6,7,11,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-17-yl) Hydrogen Sulfate

This intriguing compound represents a fascinating intersection of chemistry and biology. As a sulfated steroid, it possesses unique features due to the presence of multiple methoxy groups and an extensive hydrocarbon framework. Here are some key points to consider:

  • Steroidal Backbone: The compound's structure is based on a steroid framework, which is critical for many biological activities. Steroids play essential roles in hormone regulation and cellular processes within living organisms.
  • Sulfate Group: The inclusion of a hydrogen sulfate group may enhance its solubility and biological interaction, allowing it to act more effectively in specific biochemical pathways.
  • Potential Pharmacological Applications: Steroidal compounds with similar functional groups have been studied for their potential as anti-inflammatory agents, hormone replacement therapies, and even cancer treatments.
  • Molecular Complexity: The multiple methoxy groups add significant steric bulk and electronic characteristics, potentially influencing the compound's reactivity and interaction with biological targets.
  • Research Significance: Compounds like this one are often synthesized for the purpose of advancing pharmaceutical sciences and understanding chemical interactions at a molecular level.

As stated by researchers, “Understanding the subtle changes in molecular structure can lead to groundbreaking therapeutic advancements.” This particular compound exemplifies how intricate chemistry can lead to exciting potential applications in medicine and biochemistry!