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2,3,4,5-Tetrafluoroaniline

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Identification
Molecular formula
C6H3F4NH2
CAS number
1763-23-1
IUPAC name
2,3,4,5-tetrafluoroaniline
State
State
At room temperature, 2,3,4,5-tetrafluoroaniline is typically found in the solid state. It is a stable compound under normal conditions and does not rapidly decompose.
Melting point (Celsius)
50.00
Melting point (Kelvin)
323.15
Boiling point (Celsius)
187.00
Boiling point (Kelvin)
460.15
General information
Molecular weight
163.09g/mol
Molar mass
163.0910g/mol
Density
1.5250g/cm3
Appearence

2,3,4,5-Tetrafluoroaniline is a colorless to pale yellow solid. It has a crystalline structure and can appear as either fine crystalline powder or flakes, depending on the purity and specific preparation methods. Due to the presence of multiple fluorine atoms, it may display fluorescence under UV light.

Comment on solubility

Solubility of 2,3,4,5-Tetrafluoroaniline

2,3,4,5-Tetrafluoroaniline, a fluorinated aromatic amine, presents unique solubility characteristics influenced by its chemical structure and the presence of fluorine atoms. Understanding its solubility is crucial for various applications, particularly in chemical synthesis and material science.

Key Solubility Insights:

  • Polarity: The fluorine substituents enhance the polarity of the compound, which typically increases solubility in polar solvents such as water and alcohols.
  • Hydrogen Bonding: The amine group (-NH2) allows for potential interaction through hydrogen bonding, further influencing solubility in polar environments.
  • Solvent Interaction: 2,3,4,5-Tetrafluoroaniline may be less soluble in non-polar solvents due to its increased polarity, making it more favorable for solvents like dimethyl sulfoxide (DMSO) and other polar aprotic solvents.

In summary, while 2,3,4,5-tetrafluoroaniline demonstrates reasonable solubility in polar solvents, its solubility profile can vary significantly based on the solvent environment and temperature. As noted, "the presence of electronegative fluorine atoms can either enhance or impede solubility, depending on the context." Thus, thorough solubility testing in various solvents is recommended for specific applications.

Interesting facts

Interesting Facts about 2,3,4,5-Tetrafluoroaniline

2,3,4,5-tetrafluoroaniline is a fascinating chemical compound with significant implications in various fields of chemistry and materials science. Here are some compelling aspects of this compound:

  • Fluorinated Aromatics: As a fluorinated derivative of aniline, 2,3,4,5-tetrafluoroaniline showcases a unique blend of properties derived from both the fluorine substituents and the amino group. This combination influences its reactivity and interaction with other molecules.
  • Applications in Synthesis: This compound plays a vital role in the synthesis of advanced materials, particularly in pharmaceuticals and agrochemicals. Its tetravalent fluorination can enhance the bioactivity of certain drugs.
  • Study of Electron Distribution: The presence of fluorine atoms can significantly alter the electron distribution within the molecule, affecting how it interacts with both nucleophiles and electrophiles. This characteristic makes it a subject of interest for computational chemists studying molecular interactions.
  • Environmental Impact: Research into the environmental impact of fluorinated compounds is ongoing, as they may persist in the environment longer than their non-fluorinated counterparts. Understanding 2,3,4,5-tetrafluoroaniline's behavior is critical for mitigating its ecological footprint.
  • Fluorine Substitution Effects: The tetrafluoro substitution pattern modifies not only the chemical reactivity but also physical properties such as hydrophobicity, which can have consequences in material science applications.

In summary, 2,3,4,5-tetrafluoroaniline stands out due to its unique structural features and diverse applications. As scientists continue to explore its properties, this compound may lead to innovative developments across various industries, underscoring the importance of fluorinated compounds in modern chemistry.

Synonyms
2,3,4,5-TETRAFLUOROANILINE
5580-80-3
Aniline, 2,3,4,5-tetrafluoro-
Benzenamine, 2,3,4,5-tetrafluoro-
JOA1MYY729
2,3,4,5-Tetrafluorobenzenamine
NSC 89357
NSC-89357
UNII-JOA1MYY729
DTXSID80204387
DTXCID80126878
Aniline, 2,3,4,5-tetrafluoro-(8CI)
Benzenamine, 2,3,4,5-tetrafluoro-(9CI)
623-566-6
beecaqihcytzhc-uhfffaoysa-n
MFCD00025153
Benzenamine, tetrafluoro-
Tetrafluoroaniline
NSC89357
Aniline, 2,3,4,5-tetrafluoro- (8CI)
2,4,5-Tetrafluoroaniline
NCIOpen2_001335
71964-99-3
Aniline,3,4,5-tetrafluoro-
SCHEMBL998262
2,3,4,5-tetrafluoro-aniline
Benzenamine,3,4,5-tetrafluoro-
2,3,4,5-Tetrafluoroaniline, 98%
AKOS015854352
AC-3703
CS-W021477
SB76365
AS-14406
BP-11096
SY032812
DB-017732
NS00062995
T2782
A19773
EN300-128638
2,3,4,5-Tetrafluorobenzenamine;2,3,4,5-Tetrafluoroa
Z1255383062