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Estrone

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Identification
Molecular formula
C18H22O2
CAS number
53-16-7
IUPAC name
2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17-hexadecahydro-1H-cyclopenta[a]phenanthren-3-ol
State
State

Solid at room temperature. Estrone is typically found as a solid under ambient conditions due to its crystalline structure and relatively high melting point compared to many other organic compounds.

Melting point (Celsius)
254.00
Melting point (Kelvin)
527.15
Boiling point (Celsius)
381.00
Boiling point (Kelvin)
654.15
General information
Molecular weight
270.37g/mol
Molar mass
270.3660g/mol
Density
1.2300g/cm3
Appearence

Estrone is a white to off-white crystalline powder. It is generally found in a solid state and can have a faint odor. Due to its fine particulate nature, it can appear fluffy when handled and lacks significant color in its pure form.

Comment on solubility

Solubility of 2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17-hexadecahydro-1H-cyclopenta[a]phenanthren-3-ol (C18H22O2)

The solubility of 2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17-hexadecahydro-1H-cyclopenta[a]phenanthren-3-ol is an intriguing topic due to several factors that influence its behavior in various solvents. This compound, characterized by its hydrophobic cyclopenta[a]phenanthrene structure and hydroxyl group, presents unique solubility characteristics.

Key Points on Solubility:

  • Polarity Considerations: Given its non-polar hydrocarbon framework, the compound is expected to have limited solubility in polar solvents such as water.
  • Solvation Environment: It may be more soluble in organic solvents, particularly those that are non-polar or weakly polar, such as hexane or ethyl acetate.
  • Hydroxyl Influence: The presence of the hydroxyl (-OH) group can enhance solubility in certain polar solvents, primarily those that can engage in hydrogen bonding, albeit to a lesser extent due to the hydrophobic character of the remaining structure.
  • Concentration and Temperature: The solubility may also vary significantly with changes in concentration and temperature, and such variations should be taken into account during practical applications.

In conclusion, the solubility of C18H22O2 reflects a complex interplay of structural features and environmental conditions. Further studies are needed to fully understand its solubility profiles across different mediums, which can play a crucial role in its applications and interactions in chemical systems.

Interesting facts

Interesting Facts About 2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17-hexadecahydro-1H-cyclopenta[a]phenanthren-3-ol

This intriguing compound, recognized for its complex structure, is a member of the steroid family, which play critical roles in biology and medicine. Here are some fascinating aspects of this chemical:

  • Derivatives and Similarities: This compound has connections to natural steroids and hormones, which are crucial for many physiological processes in living organisms, including growth, metabolism, and reproductive functions.
  • Synthetic Applications: Its structure offers avenues for synthetic modification, leading to potential insights in drug development, particularly in targeting specific receptors associated with hormonal activity.
  • Chemical Stability: The unique bicyclic structure of cyclopenta[a]phenanthrene enhances its stability, making it an interesting target for researchers exploring the robustness of steroid-like compounds.
  • Potential Biological Activity: Researchers hypothesize that compounds with similar configurations could exhibit various biological activities, including anti-inflammatory and anticancer properties, thereby urging further exploration in medicinal chemistry.
  • Inspiring Further Research: As a complex polycyclic compound, it serves as a springboard for studying polycyclic compounds, opening up questions regarding their synthesis, reactivity, and interactions within biological systems.

In summary, the 2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17-hexadecahydro-1H-cyclopenta[a]phenanthren-3-ol stands as a testament to the intricate interplay between structure and function in organic chemistry. The journey into its study not only furthers our understanding of steroid-like compounds but also paves the way for innovation in pharmaceutical applications.

Synonyms
sterol
Sterols
3-hydroxysteroids
C00370
SCHEMBL4544647
CHEBI:15889