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2,3,6-trimethylindole

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Identification
Molecular formula
C11H13N
CAS number
1611-57-6
IUPAC name
2,3,6-trimethyl-1H-indole
State
State

At room temperature, it exists as a solid.

Melting point (Celsius)
62.00
Melting point (Kelvin)
335.15
Boiling point (Celsius)
315.00
Boiling point (Kelvin)
588.15
General information
Molecular weight
159.24g/mol
Molar mass
159.2360g/mol
Density
1.0110g/cm3
Appearence

2,3,6-trimethyl-1H-indole is a yellow solid with a crystalline structure. It has a characteristic indolic odor, which is often described as earthy or musty.

Comment on solubility

Solubility of 2,3,6-trimethyl-1H-indole

2,3,6-trimethyl-1H-indole is an interesting compound with notable solubility characteristics. Understanding its solubility is crucial for various applications in chemistry and pharmaceuticals. Here are some key points regarding its solubility:

  • Solvent Compatibility: 2,3,6-trimethyl-1H-indole is known to be soluble in organic solvents such as ethanol, chloroform, and acetone.
  • Water Solubility: This compound has very limited solubility in water, which is a common trait for many indole derivatives.
  • Temperature Influence: The solubility of 2,3,6-trimethyl-1H-indole may increase with temperature, allowing for better dissolution in non-polar solvents at elevated temperatures.
  • Hydrophobic Nature: The hydrophobic alkyl groups attached to the indole ring enhance its solubility in non-polar environments, while limiting interaction with polar solvents like water.

In summary, the solubility profile of 2,3,6-trimethyl-1H-indole highlights its preference for non-polar solvents, making it a useful compound in organic synthesis and drug formulation. It serves as a fantastic example of the influence of molecular structure on solubility properties.

Interesting facts

Interesting Facts about 2,3,6-Trimethyl-1H-Indole

2,3,6-trimethyl-1H-indole is a fascinating compound that belongs to the indole family. This compound has attracted attention in various fields, particularly in organic chemistry and biochemistry. Here are some intriguing aspects of 2,3,6-trimethyl-1H-indole:

  • Structure and Stability: The indole structure consists of a fused benzene and pyrrole ring, providing unique properties that contribute to its stability and reactivity.
  • Biological Relevance: Compounds related to indole, including 2,3,6-trimethyl-1H-indole, are often found in natural products and play vital roles in biological systems. Indole derivatives are known for their involvement in the synthesis of various natural alkaloids.
  • Odor and Fragrance: This compound potentially contributes to the scent profile of certain fragrances. The strong aromatic system can be responsible for distinct olfactory characteristics.
  • Applications in Research: Indole derivatives are used in drug design and synthesis, with implications in medicinal chemistry. They can act as precursors for developing therapeutic agents with antitumor and antimicrobial properties.
  • Cultural Significance: Indoles are also significant in the field of food chemistry, where they can influence the flavor and aroma of a variety of foods.

As quoted by renowned chemists, "The properties derived from a compound's structure often dictate its functionality and application." In summary, 2,3,6-trimethyl-1H-indole exemplifies the intricate relationship between molecular structure and biological activity, making it a compound of immense interest across scientific disciplines.

Synonyms
22072-35-1
2,3,6-Trimethylindole
INDOLE, 2,3,6-TRIMETHYL-
BRN 0118884
1H-Indole, 2,3,6-trimethyl-
DTXSID10176568
5-20-07-00144 (Beilstein Handbook Reference)
RefChem:349161
DTXCID2099059
2,3,6-trimethyl-1H-indole
starbld0033395
SCHEMBL20611958
AKOS006373638
1H-INDOLE,2,3,6-TRIMETHYL-
E79642