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Berberine chloride

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Identification
Molecular formula
C20H18ClNO4
CAS number
633-65-8
IUPAC name
2,3,9,10-tetramethoxy-5,6,7,8,13,13a-hexahydroisoquinolino[2,1-b]isoquinolin-7-ium;chloride
State
State

At room temperature, berberine chloride is typically found in a solid state. It appears as a yellow crystalline powder and is used for its various biological properties.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.15
Boiling point (Celsius)
525.00
Boiling point (Kelvin)
798.15
General information
Molecular weight
372.82g/mol
Molar mass
372.8150g/mol
Density
1.3800g/cm3
Appearence

Berberine chloride is typically found as a yellow crystalline powder. It is an intensely yellow alkaloid that belongs to the protoberberine group of compounds. It is often used as a dye due to its vibrant color.

Comment on solubility

Solubility of 2,3,9,10-tetramethoxy-5,6,7,8,13,13a-hexahydroisoquinolino[2,1-b]isoquinolin-7-ium;chloride

The solubility of 2,3,9,10-tetramethoxy-5,6,7,8,13,13a-hexahydroisoquinolino[2,1-b]isoquinolin-7-ium;chloride is influenced by its structural features and the presence of the chloride ion. Understanding its solubility characteristics can provide insights for practical applications. Here are some key points regarding its solubility:

  • Polar Nature: The presence of multiple methoxy groups contributes to polar interactions, which may enhance solubility in polar solvents such as water.
  • Chloride Ion: The chloride ion, being a small and highly soluble ionic species, tends to increase overall solubility in an aqueous medium.
  • Organic Solvent Compatibility: Given the complex nature of its structure, it may demonstrate varying solubility in different organic solvents. High-quality studies are needed to crystallize relevant data.

Additionally, due to its unique structure, it might exhibit selective solubility at specific pH levels, highlighting the importance of environmental conditions in pharmacological and industrial applications. As such, further empirical research is essential to characterize its solubility behavior comprehensively.

Interesting facts

Interesting Facts about 2,3,9,10-Tetramethoxy-5,6,7,8,13,13a-Hexahydroisoquinolino[2,1-b]isoquinolin-7-ium; Chloride

This intriguing compound belongs to the larger family of isoquinoline derivatives, which have captured the interest of chemists due to their diverse biological activities. Here are some fascinating insights:

  • Structural Complexity: The compound's structure, featuring multiple methoxy groups and a unique hexahydroisoquinoline framework, enables a variety of interactions at the molecular level. The presence of these substituents can significantly influence its chemical behavior and interaction with biological systems.
  • Biological Relevance: Isoquinoline derivatives are often studied for their pharmacological properties. Compounds in this group have been linked to anti-cancer, anti-inflammatory, and antimicrobial activities, making them promising candidates for further research in drug development.
  • Potential Applications: The versatility of this compound opens doors for applications in various fields, including medicinal chemistry, organic synthesis, and potentially even materials science. Researchers are constantly exploring novel ways to utilize such compounds in therapeutic and industrial contexts.
  • Research Interest: Given its complex structure and potential for bioactivity, this compound is likely to be of great interest in academic research. Studies may focus on elucidating its mechanism of action, optimizing its properties for medical applications, or incorporating it into new synthetic pathways.

As Dr. Ada Yonath famously said, "The more you learn, the more you realize how much you don’t know." The exploration of compounds like this one exemplifies the never-ending journey of discovery in the field of chemistry.

In summary, 2,3,9,10-tetramethoxy-5,6,7,8,13,13a-hexahydroisoquinolino[2,1-b]isoquinolin-7-ium; chloride is not only a chemical curiosity with rich structural features but also a potential player in the next generation of pharmaceuticals. Its study can lead to significant advancements in our understanding of chemical reactivity and biological interactions.

Synonyms
l-Tetrahydropalmatine hydrochloride
Tetrahydropalmaline chloride
BERBINE, 2,3,9,10-TETRAMETHOXY-, HYDROCHLORIDE
2506-20-9
2,3,9,10-tetramethoxy-5,6,7,8,13,13a-hexahydroisoquinolino[2,1-b]isoquinolin-7-ium;chloride
Tetrahydropalmatine hydrochloride, (+/-)-
hydron;2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline;chloride
4AA8F911N9
NSC 132057
NSC 209411
UNII-4AA8F911N9
Palmatine, tetrahydro-, hydrochloride, (+-)-
10097-84-4
BERBINE, 2,3,9,10-TETRAMETHOXY-, HYDROCHLORIDE, (+-)-
AKOS003601183
6H-Dibenzo(a,g)quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-, hydrochloride
6H-Dibenzo(a,g)quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-, hydrochloride, (+-)-