Skip to main content

2,4-Dichlor-5-sulfamoylbenzoesäure

ADVERTISEMENT
Identification
Molecular formula
C7H5Cl2NO4S
CAS number
6489-18-5
IUPAC name
2,4-dichloro-5-sulfamoyl-benzoic acid
State
State

At room temperature, 2,4-Dichloro-5-sulfamoyl-benzoic acid is generally in a solid state. Its crystalline nature is indicative of its solid form under standard conditions, making it stable and easy to handle for laboratory use.

Melting point (Celsius)
205.00
Melting point (Kelvin)
478.00
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.00
General information
Molecular weight
296.10g/mol
Molar mass
296.0960g/mol
Density
1.6867g/cm3
Appearence

2,4-Dichloro-5-sulfamoyl-benzoic acid typically appears as a white to off-white crystalline solid. It may be available in powder form with a texture that is consistent with many organic compounds used in chemical synthesis or research environments.

Comment on solubility

Solubility of 2,4-Dichloro-5-sulfamoyl-benzoic Acid

The solubility of 2,4-dichloro-5-sulfamoyl-benzoic acid (C7H6Cl2N2O3S) is influenced by several factors related to its chemical structure.

General Characteristics

  • Polarity: The presence of the sulfamoyl group (-SO2NH2) increases the polarity of the compound, enhancing its solubility in polar solvents such as water.
  • Acidity: As a benzoic acid derivative, it can donate protons (H+) to the solvent, further contributing to its solubility in aqueous solutions.

Solubility Trends

Despite its polarity, the solubility can vary significantly based on:

  • Temperature: Higher temperatures often increase solubility by disrupting intermolecular interactions.
  • pH Levels: Changes in pH can affect the ionization of the carboxylic acid group, influencing solubility.

In conclusion, while 2,4-dichloro-5-sulfamoyl-benzoic acid is generally more soluble in polar solvents, its precise solubility will depend on the environmental conditions and the specific interactions occurring in the solvent phase. As a reminder, **solubility is a dynamic property** that can change with varying conditions.

Interesting facts

Interesting Facts about 2,4-Dichloro-5-sulfamoyl-benzoic Acid

2,4-Dichloro-5-sulfamoyl-benzoic acid is a fascinating compound that captures the interest of chemists and researchers alike. Here are some noteworthy aspects of this intriguing chemical:

  • Pharmaceutical Applications: This compound is notable for its role as a key intermediate in the synthesis of various pharmaceuticals, particularly in the development of drugs that target bacterial infections. Its sulfamoyl group contributes to its biological activity.
  • Environmental Significance: Compounds containing dichlorobenzene derivatives, like this one, are often scrutinized for their environmental impact. Understanding their behavior can aid in assessing and mitigating pollution.
  • Structure-Activity Relationship (SAR): The presence of the sulfamoyl and dichloro functional groups in the molecular structure of 2,4-dichloro-5-sulfamoyl-benzoic acid influences its pharmacological properties. This relationship is pivotal for medicinal chemistry and drug design.
  • Chiral Properties: While this particular compound does not exhibit chirality, discussions around related benzene derivatives often advocate for the significance of stereochemistry in biological systems, which could lead to novel drug compounds.
  • Laboratory Synthesis: The synthesis of 2,4-dichloro-5-sulfamoyl-benzoic acid typically involves several steps of chemical reactions, demonstrating the complexity and precision required in modern organic chemistry.

As noted by some researchers, *"The exploration of chemical compounds like 2,4-dichloro-5-sulfamoyl-benzoic acid not only propels pharmaceutical advancements but also enhances our understanding of chemical interactions in biological systems."* This compound is a prime example of how chemistry intersects with health and environmental science, making it a notable subject for both academic study and practical application.

Synonyms
2,4-Dichloro-5-sulfamoylbenzoic acid
Lasamide
2,4-Dichloro-5-sulphamoylbenzoic acid
5-(Aminosulfonyl)-2,4-dichlorobenzoic acid
M 12325
UNII-LEG53TF0SN
LEG53TF0SN
EINECS 220-358-3
BRN 2219046
DTXSID90181791
EC 220-358-3
2,4-Dichloro-5-sulfonamidobenzoic acid
FUROSEMIDE IMPURITY B [EP IMPURITY]
FUROSEMIDE IMPURITY B (EP IMPURITY)
M-12325
DTXCID30104282
2,4Dichloro5sulfamoylbenzoic acid
3Sulfamoyl4,6dichlorobenzoic acid
2,4Dichloro5sulphamoylbenzoic acid
5Carboxy2,4dichlorobenzenesulfonamide
Benzoic acid, 2,4dichloro5sulfamoyl
5-aminosulfonyl-2,4-dichlorobenzoate
5Aminosulfonyl2,4dichlorobenzoic acid
Benzoic acid, 5(aminosulfonyl)2,4dichloro
inchi=1/c7h5cl2no4s/c8-4-2-5(9)6(15(10,13)14)1-3(4)7(11)12/h1-2h,(h,11,12)(h2,10,13,14
zshhrbyvhtvrfk-uhfffaoysa-n
2736-23-4
2,4-Dichloro-5-sulfamoyl-benzoic acid
3-Sulfamoyl-4,6-dichlorobenzoic acid
Benzoic acid, 5-(aminosulfonyl)-2,4-dichloro-
BENZOIC ACID, 2,4-DICHLORO-5-SULFAMOYL-
5-Carboxy-2,4-dichlorobenzenesulfonamide
5-Aminosulfonyl-2,4-dichlorobenzoic acid
MFCD00007931
LeadQuest Compound 9
Furosemide Imp. B (EP); 2,4-Dichloro-5-sulphamoylbenzoic Acid; Furosemide Impurity B
V8I
Oprea1_168593
Oprea1_483230
SCHEMBL574023
CHEMBL120886
BDBM13075
ALBB-025776
BBL010665
STK298896
AKOS000143948
CS-W014032
AC-11765
AS-10817
BP-12719
SY049410
DB-047210
D2541
NS00001312
EN300-16167
D70121
SR-01000537051
SR-01000537051-1
Q27282949
Z53021521
F1901-0102