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Diclofenac

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Identification
Molecular formula
C14H10Cl2NO2
CAS number
15307-86-5
IUPAC name
(2,4-dichlorophenyl) 2-hydroxyacetate
State
State

At room temperature, diclofenac is usually in a solid state.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
207.00
Boiling point (Kelvin)
480.15
General information
Molecular weight
296.15g/mol
Molar mass
296.1480g/mol
Density
1.6480g/cm3
Appearence

Diclofenac typically appears as a white to slightly yellow, crystalline powder. It is practically insoluble in water and freely soluble in common organic solvents such as dichloromethane, acetone, and methanol.

Comment on solubility

Solubility of (2,4-dichlorophenyl) 2-hydroxyacetate

(2,4-dichlorophenyl) 2-hydroxyacetate is a compound known for its unique structural attributes that can significantly influence its solubility in various solvents. Analyzing the solubility characteristics of this compound reveals a few key points:

  • Polarity: The presence of the -OH (hydroxyl) group enhances the polarity of the molecule, which can improve its solubility in polar solvents like water.
  • Aromatic Characteristics: The chloro substituents on the aromatic ring can create steric hindrance and can affect the overall solubility in organic solvents.
  • Hydrophobic vs. Hydrophilic: The competition between the hydrophilic -OH group and the hydrophobic aromatic ring imparts a dual nature to the solubility of this compound, potentially leading to variable solubility behavior depending on the environmental conditions.
  • Temperature Dependence: Like many compounds, solubility may increase with temperature; therefore, testing at various temperatures can provide insights into its solubility profile.

In conclusion, understanding the solubility of (2,4-dichlorophenyl) 2-hydroxyacetate requires careful consideration of its molecular interactions. As a quote sums it up: "The solubility depends on the delicate balance between hydrophobic and hydrophilic forces." This delicate balance underlines the importance of solvent choice when working with this compound.

Interesting facts

Interesting Facts about (2,4-Dichlorophenyl) 2-Hydroxyacetate

(2,4-Dichlorophenyl) 2-hydroxyacetate is a fascinating compound with several noteworthy attributes, especially in the fields of pharmaceuticals and chemical research. Here are some compelling points about this compound:

  • Pharmaceutical Relevance: This compound is closely related to a class of drugs known for their anti-inflammatory properties, making it significant in pain management and therapeutic applications.
  • Environmental Considerations: The presence of chlorine atoms in its structure suggests a need for careful consideration in environmental contexts, as chlorinated compounds can have different degradation pathways in the ecosystem.
  • Molecular Interactions: The hydroxyl group (-OH) in the structure enhances its ability to engage in hydrogen bonding, which can affect its biological activity and solubility.
  • Structure-Activity Relationship: Studying the structure of (2,4-dichlorophenyl) 2-hydroxyacetate provides insight into how modifications in chemical structure can influence biological activity, which is a foundational concept in medicinal chemistry.

As noted by many chemists, "The beauty of chemistry lies in understanding how small changes in a compound’s structure can lead to significant differences in its function and efficacy." This perspective is particularly relevant when discussing compounds like (2,4-dichlorophenyl) 2-hydroxyacetate.

In conclusion, (2,4-dichlorophenyl) 2-hydroxyacetate exemplifies the intricate balance between chemical structure and biological function, making it a valuable subject of study for those interested in both the theoretical and practical aspects of chemistry.

Synonyms
SCHEMBL6409790
NS00007317