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2,4-Difluoroaniline

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Identification
Molecular formula
C6H5F2N
CAS number
367-25-9
IUPAC name
2,4-difluoroaniline
State
State

2,4-Difluoroaniline is usually in a liquid state at room temperature. It may be solid if cooled to its melting point.

Melting point (Celsius)
10.00
Melting point (Kelvin)
283.15
Boiling point (Celsius)
173.00
Boiling point (Kelvin)
446.15
General information
Molecular weight
129.11g/mol
Molar mass
129.1130g/mol
Density
1.3335g/cm3
Appearence

2,4-Difluoroaniline is a colorless to light brown liquid. It is typically clear if pure but can be light brown if impurities are present. The compound has a characteristic aromatic amine odor.

Comment on solubility

Solubility of 2,4-difluoroaniline

2,4-difluoroaniline, with the chemical formula C6H5F2NH2, exhibits notable solubility characteristics that can be summarized as follows:

  • Polar Nature: The presence of the amino group (-NH2) and fluorine atoms contributes to the polar character of this compound.
  • Solubility in Water: Due to its polar functional groups, 2,4-difluoroaniline demonstrates moderate solubility in water, allowing it to interact and form hydrogen bonds with water molecules.
  • Solubility in Organic Solvents: It is generally more soluble in organic solvents such as ethanol and ether, which facilitate interactions with its non-polar aromatic rings.
  • Temperature Dependence: Like many organic compounds, its solubility may increase with temperature, which should be considered during applications involving this compound.

In summary, 2,4-difluoroaniline's solubility is a blend of its polar and non-polar regions, making it versatile for various chemical processes. As the saying goes, "Like dissolves like," and this compound exemplifies that principle in both aqueous and organic environments.

Interesting facts

Interesting Facts about 2,4-Difluoroaniline

2,4-Difluoroaniline is a fascinating chemical compound that belongs to the class of anilines, which are organic compounds known for their nitrogen-containing aromatic amines. This compound features two fluorine atoms attached to the aromatic ring at the 2 and 4 positions. Here are some notable aspects of 2,4-difluoroaniline:

  • Pharmaceutical Applications: 2,4-Difluoroaniline serves as an important precursor in the synthesis of various pharmaceuticals. Its structural properties make it valuable for developing drugs targeting infections and diseases.
  • Substitution Reactions: The presence of fluorine enhances the reactivity of the compound, making it an excellent candidate for a variety of electrophilic substitution reactions, which are fundamental in organic chemistry.
  • Environmental Impact: As with many fluorinated compounds, understanding the behavior of 2,4-difluoroaniline in the environment is crucial, especially regarding its biodegradability and potential toxicity to aquatic life.
  • Toxicology Studies: Research involving 2,4-difluoroaniline often focuses on its toxicity and effects on human health, particularly because compounds containing fluorine have shown varying degrees of toxicity depending on their structure.

As Chemists or aspiring chemistry students, it's essential to delve deeper into the properties and implications of working with such a compound. Exploring its synthesis pathways, the effects of fluorine substitution, and its potential applications can prove to be both rewarding and intriguing. Remember, as the great chemist Marie Curie once said, “Nothing in life is to be feared; it is only to be understood.” Embracing this mindset will uncover the mysteries behind compounds like 2,4-difluoroaniline.

Synonyms
2,4-DIFLUOROANILINE
367-25-9
2,4-Difluorobenzenamine
Benzenamine, 2,4-difluoro-
2,4-Difluroaniline
2,4-Difluorophenylamine
Aniline, 2,4-difluoro-
CCRIS 4621
EINECS 206-687-5
UNII-40P93L7KWD
MFCD00007648
NSC 10297
2.4-difluoroaniline
BRN 2802556
40P93L7KWD
DTXSID6025064
AI3-52650
NSC-10297
DTXCID905064
DIFLUOROANILINE, 2,4-
CEPCPXLLFXPZGW-UHFFFAOYSA-
EC 206-687-5
2,4-DIFLUOROANILINE [MI]
4-12-00-01112 (Beilstein Handbook Reference)
2,4-Difluoro Aniline
2,4-Difluoro-phenylamine
2,4difluoroaniline
Aniline,4-difluoro-
2,4 -difluoroaniline
2,4 difluoro aniline
2,4-di-fluoroaniline
2,4-difluoro-aniline
2, 4-Difluoroaniline
Benzenamine,4-difluoro-
(2,4-difluorophenyl)amine
SCHEMBL11425
2,?4-?difluoro-Benzenamine
2,4-Difluoroaniline, 99%
BIDD:GT0098
CHEMBL1423658
NSC10297
Tox21_200620
STL264190
AKOS000119718
CCG-302504
CS-W020027
PS-9155
SDCCGMLS-0066219.P001
NCGC00091684-01
NCGC00091684-02
NCGC00258174-01
AC-10532
CAS-367-25-9
DB-005860
D1508
NS00009496
EN300-19930
A25254
D50070
Q27258348
F2182-0028
Z104476120
2,4-difluoro-anilin;Aniline, 2,4-difluoro-;Benzenamine, 2,4-difluoro-
206-687-5