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2,6-bis(trifluoromethyl)-1H-benzimidazole

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Identification
Molecular formula
C9H4F6N2
CAS number
66867-33-2
IUPAC name
2,6-bis(trifluoromethyl)-1H-benzimidazole
State
State

Under standard conditions, 2,6-bis(trifluoromethyl)-1H-benzimidazole exists as a solid. It typically has a stable crystalline structure.

Melting point (Celsius)
148.00
Melting point (Kelvin)
421.15
Boiling point (Celsius)
310.00
Boiling point (Kelvin)
583.15
General information
Molecular weight
308.14g/mol
Molar mass
308.1960g/mol
Density
1.5444g/cm3
Appearence

2,6-bis(trifluoromethyl)-1H-benzimidazole typically appears as a white to pale yellow crystalline powder. The compound is often very fine and may appear slightly off-white depending on the purity and particle size.

Comment on solubility

Solubility of 2,6-bis(trifluoromethyl)-1H-benzimidazole

The solubility of 2,6-bis(trifluoromethyl)-1H-benzimidazole in various solvents can be influenced by its unique chemical structure. Here are some key points regarding its solubility:

  • Polar Solvents: Generally, compounds containing strong electronegative groups, such as the trifluoromethyl groups in this compound, demonstrate some level of solubility in polar solvents. However, the solubility may be limited due to overall hydrophobic characteristics.
  • Non-Polar Solvents: With a considerable portion of its structure being hydrophobic, 2,6-bis(trifluoromethyl)-1H-benzimidazole is likely to be more soluble in non-polar solvents, such as toluene or hexane. Its bulky structure may hinder interaction with polar solvents.
  • Temperature Influence: Solubility can also be temperature dependent. Typically, an increase in temperature may enhance solubility in organic solvents through increased kinetic energy leading to better dispersion.
  • Presence of Other Compounds: The solubility may vary depending on the presence of other solutes or specific conditions within the solution (such as pH), which can affect interaction dynamics.

In summary, while 2,6-bis(trifluoromethyl)-1H-benzimidazole may show some solubility in polar solvents due to its trifluoromethyl groups, its overall hydrophobic nature makes it preferentially soluble in non-polar organic solvents. Understanding these solubility attributes is crucial for applications in synthesis and formulation.

Interesting facts

Interesting Facts about 2,6-bis(trifluoromethyl)-1H-benzimidazole

2,6-bis(trifluoromethyl)-1H-benzimidazole is a fascinating compound with unique properties that have garnered the attention of chemists and researchers alike. Here are some interesting facts:

  • Structural Uniqueness: This compound features a benzimidazole backbone, which is essential for its function and reactivity. The presence of two trifluoromethyl groups enhances its chemical stability and lipophilicity, which are crucial in various applications.
  • Potential Applications: The compound is being explored for its potential use in pharmaceuticals, where the trifluoromethyl groups may play a role in improving the efficacy of drug molecules. Additionally, it may have applications in agrochemicals due to its ability to interact with biological systems.
  • Fluorine Significance: The incorporation of fluorine atoms in organic molecules is known to enhance their biological activity. Fluorine's electronegativity contributes to the unique electronic properties of the compound that are useful in medicinal chemistry.
  • Research Interest: As a subject of ongoing research, studies have shown that derivatives of 2,6-bis(trifluoromethyl)-1H-benzimidazole often exhibit interesting biological activities, making them candidates for further exploration in drug design.
  • Physical Properties: Although specific physical properties may not be addressed, compounds of this nature generally have intriguing interactions with solvents and biomolecules, which is critical for their functionality in various chemical environments.

In summary, 2,6-bis(trifluoromethyl)-1H-benzimidazole is a remarkable compound that exemplifies how subtle modifications at the molecular level can lead to significant changes in chemical behavior and potential applications. As research continues, who knows what new discoveries await?

Synonyms
399-69-9
2,6-bis(trifluoromethyl)-1H-benzimidazole
BENZIMIDAZOLE, 2,5-BIS(TRIFLUOROMETHYL)-
2,5-Bis(trifluoromethyl)-1H-benzo[d]imidazole
2,5-Bis(trifluoromethyl)benzimidazole
BRN 0027277
2,5-Bis(trifluoromethyl)-1H-benzimidazole
4-23-00-01150 (Beilstein Handbook Reference)
SCHEMBL5681855
SCHEMBL10694441
DTXSID50192944
BKFXAUQYNCJXIZ-UHFFFAOYSA-N
AKOS003197327
2,5-bis(trifluoromethyl)-benzimidazole
Q63392124