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Sulfadoxine

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Identification
Molecular formula
C12H17N4O4S
CAS number
2447-57-6
IUPAC name
[2,6-diamino-4-(1-piperidyl)pyrimidin-1-ium-1-yl] hydrogen sulfate
State
State

At room temperature, sulfadoxine is typically a solid.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
525.15
Boiling point (Kelvin)
798.15
General information
Molecular weight
310.34g/mol
Molar mass
310.3350g/mol
Density
2.3240g/cm3
Appearence

It is typically found as a white crystalline powder. The compound is often odorless or may have a slight organic smell.

Comment on solubility

Solubility of [2,6-diamino-4-(1-piperidyl)pyrimidin-1-ium-1-yl] hydrogen sulfate

The solubility of the compound [2,6-diamino-4-(1-piperidyl)pyrimidin-1-ium-1-yl] hydrogen sulfate, with the chemical formula C12H17N4O4S, is influenced by several factors including its ionic nature, molecular structure, and the solvent used. Here are some key points regarding its solubility:

  • Ionic Character: The presence of the hydrogen sulfate component typically indicates that the compound is ionic, which generally improves solubility in polar solvents, such as water.
  • Molecular Structure: The presence of multiple amino groups in the structure can contribute to higher solubility due to the formation of hydrogen bonds with water molecules.
  • Temperature Dependence: As with many ionic compounds, solubility may increase with temperature, allowing for greater dissociation of the ions into the solvent.
  • Solvent Specificity: While this compound is likely soluble in water, its solubility profile in non-polar solvents might be significantly lower, reflecting its polar characteristics.

Overall, one might expect [2,6-diamino-4-(1-piperidyl)pyrimidin-1-ium-1-yl] hydrogen sulfate to be moderately to highly soluble in aqueous solutions, warranting further experimentation to quantify its solubility under varying conditions.

Interesting facts

Interesting Facts about [2,6-Diamino-4-(1-piperidyl)pyrimidin-1-ium-1-yl] Hydrogen Sulfate

This unique compound, known as [2,6-diamino-4-(1-piperidyl)pyrimidin-1-ium-1-yl] hydrogen sulfate, is notable for its various applications in the field of medicinal chemistry. Here are some intriguing aspects of this compound:

  • Pharmacological Potential: The presence of the pyrimidin and piperidyl structures suggests potential use in creating pharmaceuticals, particularly in the development of antihypertensive or anti-cancer agents.
  • Structure-Activity Relationship: The positions of the amino groups in the pyrimidine ring can significantly influence the compound's biological activity. Such modifications can be pivotal in optimizing the efficacy of drug candidates.
  • Charge Considerations: As a quaternary ammonium compound, the positive charge may enhance solubility in biological systems, potentially leading to improved bioavailability.
  • Sulfate Role: The inclusion of hydrogen sulfate not only provides stability to the compound but may also be involved in certain biochemical interactions within the body, making it an interesting subject for further research.

As chemists continue to explore the properties and applications of such compounds, the integration of various functional groups could lead to breakthroughs in treatment methodologies. Overall, this compound represents a fascinating intersection of organic chemistry and medicinal applications, emphasizing the endless possibilities of chemical research.

Synonyms
(2,6-diamino-4-piperidin-1-ylpyrimidin-1-ium-1-yl) hydrogen sulfate
Bio1_000086
CBiol_001800
BSPBio_001387
KBioGR_000107
KBioSS_000107
SCHEMBL9622285
KBio2_000107
KBio2_002675
KBio2_005243
KBio3_000213
KBio3_000214
CHEBI:143426
Bio1_000575
Bio1_001064
Bio2_000107
Bio2_000587
IDI1_033857