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Lidocaine

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Identification
Molecular formula
C14H22N2O
CAS number
137-58-6
IUPAC name
(2,6-dimethylphenyl) 2-(diethylamino)propanoate
State
State

At room temperature, lidocaine is typically encountered in its solid form as a powder or crystalline substance. It can be dissolved in water for various applications.

Melting point (Celsius)
68.00
Melting point (Kelvin)
341.15
Boiling point (Celsius)
350.80
Boiling point (Kelvin)
623.95
General information
Molecular weight
234.34g/mol
Molar mass
234.3410g/mol
Density
1.0260g/cm3
Appearence

Lidocaine commonly appears as a white solid powder. It is odorless and has a slightly bitter taste. It is often supplied in a crystalline form and is soluble in water and most organic solvents.

Comment on solubility

Solubility of (2,6-dimethylphenyl) 2-(diethylamino)propanoate

The solubility of the compound (2,6-dimethylphenyl) 2-(diethylamino)propanoate can be considered complex due to the presence of various functional groups. Here are some important aspects regarding its solubility:

  • Polarity: The presence of the diethylamino group can enhance the polarity of the molecule, which may increase its solubility in polar solvents such as water or ethanol.
  • Hydrophobic Domain: The dimethylphenyl moiety contributes a hydrophobic character, which can make the compound less soluble in polar solvents and more soluble in non-polar solvents like hexane or toluene.
  • Interactions: The solubility could also be influenced by factors such as hydrogen bonding and van der Waals interactions with the solvent molecules.

In summary, the solubility of (2,6-dimethylphenyl) 2-(diethylamino)propanoate can be expected to vary significantly depending on the solvent used. For practical purposes, it is often described as:

  1. Soluble in organic solvents
  2. Moderately soluble in polar solvents
  3. Insoluble in water

This variation in solubility makes it crucial to choose the appropriate solvent for applications involving this compound. Understanding these aspects helps in predicting behavior during reactions and processes.

Interesting facts

Interesting Facts About (2,6-Dimethylphenyl) 2-(Diethylamino)propanoate

(2,6-Dimethylphenyl) 2-(diethylamino)propanoate is an intriguing compound that has garnered attention in various fields, particularly in medicinal chemistry. Here are some fascinating aspects of this compound:

  • Pharmaceutical Applications: This compound serves as an important intermediate in the synthesis of pharmaceuticals, often used as a building block in the development of drugs targeting the central nervous system.
  • Amine Functional Group: The presence of the diethylamino group contributes significantly to its pharmacological profile, enhancing solubility and biological activity.
  • Substituted Aromatics: The 2,6-dimethyl substitution on the phenyl ring increases lipophilicity, which can affect the compound’s ability to cross biological membranes, making it more bioavailable.
  • Structure-Activity Relationship (SAR): Scientists often study SAR to understand how structural variations influence the activity of compounds like this one. Modifications to the phenyl or amino groups can yield insights into optimal drug design.
  • Potential for Innovation: Ongoing research on compounds with similar structures may lead to novel drugs or therapeutic agents that could address unmet medical needs.

The study of (2,6-dimethylphenyl) 2-(diethylamino)propanoate illustrates the beauty of organic chemistry, where subtle changes in a molecule can lead to profound differences in activity and application.

As chemists continue to explore the potentials of such compounds, the journey of discovery is likely to usher in new and exciting therapeutic avenues.