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Varenicline

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Identification
Molecular formula
C13H17NO
CAS number
249296-44-4
IUPAC name
(2R)-2-methyl-2-[(4R)-4-methyl-2,2-diphenyl-1,3-dioxolan-4-yl]piperidine
State
State

At room temperature, the compound is typically found in a solid state.

Melting point (Celsius)
208.00
Melting point (Kelvin)
481.15
Boiling point (Celsius)
359.80
Boiling point (Kelvin)
632.95
General information
Molecular weight
211.32g/mol
Molar mass
211.3180g/mol
Density
1.0860g/cm3
Appearence

The compound typically appears as a solid, crystalline substance that may have a white or off-white color.

Comment on solubility

Solubility of (2R)-2-methyl-2-[(4R)-4-methyl-2,2-diphenyl-1,3-dioxolan-4-yl]piperidine

The solubility of (2R)-2-methyl-2-[(4R)-4-methyl-2,2-diphenyl-1,3-dioxolan-4-yl]piperidine can be a nuanced topic due to its unique structural characteristics. Understanding its solubility involves several factors:

  • Polarity: The presence of multiple aromatic rings and dioxolane groups tends to increase the compound's polarity, affecting its solubility in various solvents.
  • Solvent Interaction: It is likely to exhibit higher solubility in organic solvents, such as ethanol or dimethyl sulfoxide (DMSO), compared to aqueous environments.
  • Temperature Influence: Solubility can improve with increased temperature, facilitating dissolution.
  • Hydrophobic Effects: The diphenyl and methyl groups render part of the compound hydrophobic, making it less soluble in polar solvents like water.

In conclusion, while the exact solubility values may vary, it is generally observed that (2R)-2-methyl-2-[(4R)-4-methyl-2,2-diphenyl-1,3-dioxolan-4-yl]piperidine is likely to be poorly soluble in water and more soluble in organic solvents. As a guiding principle, "like dissolves like" often holds true, where substances tend to dissolve better in solvents of similar polarity.

Interesting facts

Interesting Facts about (2R)-2-methyl-2-[(4R)-4-methyl-2,2-diphenyl-1,3-dioxolan-4-yl]piperidine

This intriguing compound belongs to the class of piperidine derivatives and has garnered interest for its unique structural features and potential applications in medicinal chemistry. Here are some interesting aspects:

  • Structural Complexity: The presence of both piperidine and dioxolane moieties showcases the complexity of the compound. The dual ring systems can influence the molecule's reactivity, stability, and biological activity.
  • Stereochemistry: The notation (2R) and (4R) indicates the chiral centers present in the molecule, which can significantly affect the compound's interactions with biological systems, including receptor binding and enzyme activity.
  • Potential Pharmacological Applications: Derivatives of piperidine are often found in various pharmaceuticals. This specific compound could exhibit fascinating properties, including analgesic, anti-inflammatory, or even anti-cancer effects due to its complex structure.
  • Interactions with Biological Targets: The unique structural elements may enable this compound to interact with various biological targets effectively, making it a subject of interest for drug design and discovery.
  • Research Opportunities: Scientists may explore its synthesis, reactivity, and potential for modifications to enhance efficacy or reduce side effects in pharmaceutical applications.

In summary, (2R)-2-methyl-2-[(4R)-4-methyl-2,2-diphenyl-1,3-dioxolan-4-yl]piperidine represents an impressive example of how molecular complexity can lead to diverse biological activities, paving the way for innovative research in the field of medicinal chemistry.

Synonyms
PDSP1_000675
PDSP2_000665
NS00123348