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Loperamide Hydrochloride

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Identification
Molecular formula
C29H33ClN2O2
CAS number
34552-83-5
IUPAC name
(2R)-2-methyl-2-[(4R)-4-methyl-2,2-diphenyl-1,3-dioxolan-4-yl]piperidine;hydrochloride
State
State

At room temperature, loperamide hydrochloride is in a solid state. It is typically found as a finely granulated powder which may be used for tablet formulation, or suspension in pharmaceutical products.

Melting point (Celsius)
223.50
Melting point (Kelvin)
496.60
Boiling point (Celsius)
319.20
Boiling point (Kelvin)
592.20
General information
Molecular weight
477.03g/mol
Molar mass
477.0330g/mol
Density
1.1900g/cm3
Appearence

Loperamide hydrochloride appears as a white to off-white, crystalline powder. It is odorless and has a slightly bitter taste. The compound is quite stable under normal conditions and is typically used in its salt form for pharmaceutical applications.

Comment on solubility

Solubility of (2R)-2-methyl-2-[(4R)-4-methyl-2,2-diphenyl-1,3-dioxolan-4-yl]piperidine; hydrochloride

The solubility of (2R)-2-methyl-2-[(4R)-4-methyl-2,2-diphenyl-1,3-dioxolan-4-yl]piperidine; hydrochloride can be influenced by various factors, including its chemical structure and the presence of the hydrochloride ion.

Key Points on Solubility:

  • Hydrochloride Form: As a hydrochloride salt, this compound is typically more soluble in water compared to its base form due to the ionic interaction with water molecules.
  • Polar Functional Groups: The presence of dioxolane and the piperidine ring contributes to the polar characteristics, aiding in solubility in polar solvents.
  • Temperature Dependence: Like many compounds, solubility may increase with temperature, which is an important consideration in synthesis and formulation applications.
  • pH Sensitivity: The solubility can be affected by the pH of the solution, particularly in the context of protonation and deprotonation equilibria.

Overall, while the solubility of this compound is favorable in aqueous solutions owing to its hydrochloride nature, the specific solubility parameters and behavior require careful experimental determination to fully understand its solubility profile and practical applications in various environments.

Interesting facts

Interesting Facts about (2R)-2-Methyl-2-[(4R)-4-Methyl-2,2-Diphenyl-1,3-Dioxolan-4-yl]Piperidine Hydrochloride

This compound, a complex organic molecule, is known for its unique structural features and potential applications in medicinal chemistry. Notably, it incorporates a piperidine ring, which is a fundamental component in many pharmaceuticals. Here are some intriguing aspects:

  • Chiral Properties: The compound features chirality, indicated by the (R) configuration. Chirality is significant in drug design, as different enantiomers can exhibit vastly different biological activities. Understanding and utilizing this can enhance the efficacy and reduce side effects of medications.
  • Dioxolane Ring: The presence of the dioxolane ring not only adds to the complexity of the molecule but also contributes to the stability and reactivity of the compound. Dioxolane derivatives are often found in compounds that exhibit interesting biochemical properties.
  • Broad Pharmaceutical Applications: Compounds sharing a similar structure have been explored for their potential as analgesics, anti-inflammatory agents, and even in tackling neurodegenerative diseases. This raises the interesting possibility that our compound might hold similar therapeutic potential.
  • Research Focus: This compound is a subject of interest in various studies focusing on drug delivery systems and the development of new therapeutic agents. Researchers are keen on exploring how its unique structure can influence biological pathways.

As part of ongoing research, scientists are investigating the mechanisms through which this compound interacts at a molecular level. The structure-activity relationship (SAR) is of particular interest, as it informs the design of new drugs that could target specific diseases more effectively. As chemistry students or scientists, exploring the nuances of such compounds can lead to groundbreaking discoveries in the field of pharmaceuticals!